{"id":10339,"date":"2020-05-22T14:36:25","date_gmt":"2020-05-22T05:36:25","guid":{"rendered":"http:\/\/aihara.la.coocan.jp\/?p=10339"},"modified":"2020-05-22T14:36:25","modified_gmt":"2020-05-22T05:36:25","slug":"%e3%82%a2%e3%83%93%e3%82%ac%e3%83%b3%e3%82%92covid-19%e6%b2%bb%e7%99%82%e3%81%ab%e4%bd%bf%e7%94%a8%e3%81%99%e3%81%b9%e3%81%8d%e3%81%8b%ef%bc%9a%ef%bc%88%ef%bc%91%ef%bc%89%e3%83%a9%e3%83%b3%e3%83%80","status":"publish","type":"post","link":"http:\/\/aihara.la.coocan.jp\/?p=10339","title":{"rendered":"\u30a2\u30d3\u30ac\u30f3\u3092COVID-19\u6cbb\u7642\u306b\u4f7f\u7528\u3059\u3079\u304d\u304b\uff1a\uff08\uff11\uff09\u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a13"},"content":{"rendered":"

\n\u30a2\u30d3\u30ac\u30f3\u306b\u3064\u3044\u3066\u8cdb\u5426\u4e21\u8ad6\u304c\u3042\u308a\u307e\u3059\u304c\u3001COVID-19\u60a3\u8005\u306b\u304a\u3051\u308b\u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a13<\/b>\u306f\u3001\u73fe\u72b6\u3067\u306f\u4ee5\u4e0b\u306e\u307f\u3067\u3059\u3002<\/p>\n

Favipiravir versus Arbidol for COVID-19: A Randomized Clinical Trial<\/b>
\nmedRxiv preprint doi: https:\/\/doi.org\/10.1101\/2020.03.17.20037432<\/a>
\nChen C, et al.\u3000(Wuhan Univ)<\/p>\n

\u3053\u306e\u8ad6\u6587\u5185\u5bb9\u3092\u307e\u3068\u3081\u308b\u3068\u6b21\u306e\u3088\u3046\u306a\u3082\u306e\u3067\u3059\u3002<\/p>\n

——————————————————
\n\u7814\u7a76\u30c7\u30b6\u30a4\u30f3\uff1a\u4e2d\u56fd\u306e3\u3064\u306e\u75c5\u9662\u3067\u884c\u308f\u308c\u305f\u591a\u65bd\u8a2d\u30aa\u30fc\u30d7\u30f3\u30e9\u30d9\u30eb\u30e9\u30f3\u30c0\u30e0\u5316\u512a\u52a3\u8a66\u9a13\uff081:1\u30e9\u30f3\u30c0\u30e0\u5316\uff09
\n\u8a66\u9a13\u767b\u9332\uff1aChiCTR2000030254<\/a><\/p>\n

\u25a0\u60a3\u8005\uff1a<\/b>\u81e8\u5e8a\u8a3a\u65ad\u306b\u3088\u308bCOVID-19\u80ba\u708e\uff08\u4e2d\u7b49\u75c7\uff09\u306e240\u4eba
\n\u25a0\u5b9f\u9a13\u7684\u6cbb\u7642\uff1a<\/b>Favipiravir\uff08\u30a2\u30d3\u30ac\u30f3\uff09\uff08\u7b2c1\u65e5\u76ee1600mgx2\/\u65e5\u3001\u305d\u306e\u5f8c600mgx2\/\u65e5\uff09
\n\u25a0\u6bd4\u8f03\u5bfe\u7167\uff1a<\/b>Umifenovir\uff08\u30a2\u30eb\u30d3\u30c9\u30fc\u30eb\uff09\uff08200mgx3\/\u65e5\u3001\u4e2d\u56fd\u306e\u6a19\u6e96\u6cbb\u7642\u306e\u4e00\u90e8\u3067\u3042\u308b\u5225\u306e\u6297\u30a6\u30a4\u30eb\u30b9\u85ac[\u30a6\u30a4\u30eb\u30b9\u306e\u4fb5\u5165\u963b\u5bb3\u85ac]\u3060\u304c\u3001in vitro\u30a8\u30d3\u30c7\u30f3\u30b9\uff09
\n\u25a0\u30a2\u30a6\u30c8\u30ab\u30e0\uff1a<\/b>
\n\u4e3b\u8981\u30a2\u30a6\u30c8\u30ab\u30e0\uff1a7\u65e5\u76ee\u306e\u81e8\u5e8a\u56de\u5fa9\u7387\uff083\u65e5\u4ee5\u4e0a\u89e3\u71b1\u3001\u547c\u5438\u6570\u3001\u9178\u7d20\u98fd\u548c\u5ea6\u3001\u54b3\u55fd\u7de9\u548c\uff09
\n\u526f\u6b21\u30a2\u30a6\u30c8\u30ab\u30e0\uff1a\u767a\u71b1\u671f\u9593\u3001\u54b3\u55fd\u671f\u9593<\/p>\n

\u25a0\u7d50\u679c\uff1a<\/b>
\n——————————————————
\n\u25cf\u60a3\u8005236\u4eba\uff08\u4e2d\u7b49\u75c7\u60a3\u8005\u306e\u5272\u5408\uff1a\u30a2\u30d3\u30ac\u30f3\u7fa485%\u3001\u30a2\u30eb\u30d3\u30c9\u30fc\u30eb\u7fa493%\uff09\u3092\u6bd4\u8f03\u3057\u305f\u3002
\nCOVID-19\u8a3a\u65ad\u306f\u81e8\u5e8a\u7684\u306b\u78ba\u8a8d\u3055\u308c\u305f\u3082\u306e\u3067\u3001\u30a6\u30a4\u30eb\u30b9\u6838\u9178\u691c\u67fb\u967d\u6027\u306f\u30a2\u30d3\u30ac\u30f3\u7fa4\u304c47%\u3001\u30a2\u30eb\u30d3\u30c9\u30fc\u30eb\u7fa4\u304c38%\u3067\u3042\u3063\u305f\u3002<\/p>\n

\u25cf\u81e8\u5e8a\u56de\u5fa9\u7387\uff087\u65e5\u76ee\uff09\u306f\u3001\u30a2\u30d3\u30ac\u30f3\u7fa4\u304c61.3\uff05\uff0871\/116\uff09\u3001\u30a2\u30eb\u30d3\u30c9\u30fc\u30eb\u7fa4\u304c51.7\uff05 \uff0862\/120\uff09\u3067\u6709\u610f\u5dee\u306f\u306a\u304b\u3063\u305f\uff08P\uff1d0.1396\uff09\u3002\u3057\u304b\u3057\u3001\u91cd\u75c7\u4f8b\u3092\u9664\u304d\u4e2d\u7b49\u75c7\u3060\u3051\u3067\u81e8\u5e8a\u56de\u5fa9\u7387\u3092\u6bd4\u8f03\u3059\u308b\u3068\u3001\u30a2\u30d3\u30ac\u30f3\u7fa4\u304c71.4\uff05\uff0870\/98\uff09\u3001\u30a2\u30eb\u30d3\u30c9\u30fc\u30eb\u7fa4\u304c55.9\uff05 \uff0862\/111\uff09 \u3067\u3042\u308a\u6709\u610f\u5dee\u304c\u898b\u3089\u308c\u305f\uff08P\uff1d0.0199\uff09\u3002<\/p>\n

\u25cf\u767a\u71b1\u671f\u9593\u3068\u54b3\u55fd\u306e\u671f\u9593\u3082\u3001\u4e2d\u7b49\u75c7\u306e\u60a3\u8005\u3067\u6bd4\u8f03\u3059\u308b\u3068\u3001\u30a2\u30d3\u30ac\u30f3\u7fa4\u304c\u30a2\u30eb\u30d3\u30c9\u30fc\u30eb\u7fa4\u3088\u308a\u3082\u3001\u6709\u610f\u306b\u77ed\u7e2e\u3057\u305f\uff08P\uff1c0.0001\uff09\u3002
\n\u25cf\u4e21\u7fa4\u306b\u304a\u3044\u3066\u6b7b\u4ea1\u8005\u306f\u306a\u304b\u3063\u305f\u3002
\n\u25cf\u30d5\u30a1\u30d3\u30d4\u30e9\u30d3\u30eb\u7fa4\u3067\u306f\u3001\u9ad8\u5c3f\u9178\u8840\u75c7\u304c\u8a8d\u3081\u3089\u308c\u305f\uff0814% vs 3%, p=0.001\uff09<\/p>\n

\u25a0\u7d50\u8ad6\uff1a<\/b>
\n\u91cd\u7be4\u3067\u306f\u306a\u3044COVID-19\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u30a2\u30d3\u30ac\u30f3\u306f\u81e8\u5e8a\u7684\u56de\u5fa9\u52b9\u679c\u3001\u767a\u71b1\u671f\u9593\u30fb\u54b3\u55fd\u671f\u9593\u306e\u77ed\u7e2e\u304c\u5f97\u3089\u308c\u308b\u3060\u308d\u3046\u3002<\/p>\n

——————————————————–
\n\u3053\u306e\u8ad6\u6587\u306b\u5bfe\u3057\u3066\u3001\u4ee5\u4e0b\u306e\u30ec\u30d3\u30e5\u30fc\u304cCONSORT\u3068\u3068\u3082\u306b\u767a\u8868\u3055\u308c\u3066\u3044\u307e\u3059\uff08Wilkinson J and Dahly D\uff09\u3002
\nStatistical review of Favipiravir versus Arbidol for COVID-19: A Randomized Clinical Trial<\/b>
\nhttps:\/\/zenodo.org\/record\/3734198#.XscgyGZ7lPY<\/a><\/p>\n

\u4e3b\u8981\u30dd\u30a4\u30f3\u30c8\u306f\u3001\u4e8b\u524d\u6307\u5b9a\u306e\u306a\u3044\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u89e3\u6790\u3067\u3042\u308b\u3001\u30e9\u30f3\u30c0\u30e0\u5316\u306e\u554f\u984c\u3001\u7d71\u8a08\u89e3\u6790\u306e\u554f\u984c\uff08\u4e8c\u5024\u5316\u3001\u6b20\u640d\u30c7\u30fc\u30bf\uff09\u306a\u3069\u306e\u3044\u304f\u3064\u304b\u306e\u554f\u984c\u3092\u6307\u6458\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

*************************
\n\u3067\u306f\u3001Wilkinson J and Dahly D\u306b\u3088\u308b\u6307\u6458\u5185\u5bb9\u306e\u4e00\u90e8\u3068\u3057\u3066\u3001\u30a2\u30a6\u30c8\u30ab\u30e0\u3092\u4e8c\u5024\u5316\u305b\u305a\u306b\u3001time-to-event\u3068\u3057\u3066\u30cf\u30b6\u30fc\u30c9\u6bd4\u3092\u7b97\u51fa\u3059\u308b\u3068\u3069\u306e\u3088\u3046\u306a\u7d50\u679c\u3067\u3001\u305d\u306e\u8cea\uff08\u30d0\u30a4\u30a2\u30b9\u306e\u30ea\u30b9\u30af\uff09\u306f\u3069\u3046\u3067\u3057\u3087\u3046\u304b\u3002<\/p>\n

\u25cf\u30cf\u30b6\u30fc\u30c9\u6bd4\uff1a<\/b>
\n*\u81e8\u5e8a\u56de\u5fa9\u7387\uff08overall\uff09\uff1aHR 1.29 (0.68-2.43)
\n*\u767a\u71b1\u671f\u9593\uff1a HR 2.42 (1.55-3.77)
\n*\u54b3\u55fd\u671f\u9593\uff1a HR 2.73 (1.75-4.27)<\/p>\n

\u3057\u305f\u304c\u3063\u3066\u3001Chen\u3089\u306eRCT\u304b\u3089\u306f\u3001\u4e3b\u8981\u30a2\u30a6\u30c8\u30ab\u30e0\u3068\u3057\u3066\u306e\u81e8\u5e8a\u56de\u5fa9\u7387\u3001\u526f\u6b21\u30a2\u30a6\u30c8\u30ab\u30e0\u3068\u3057\u3066\u306e\u767a\u71b1\u671f\u9593\u77ed\u7e2e\u3084\u54b3\u55fd\u671f\u9593\u77ed\u7e2e\u306b\u304a\u3044\u3066\u30a2\u30d3\u30ac\u30f3\u512a\u4f4d\u3067\u3059\u3002<\/p>\n

\u25cf\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u89e3\u6790<\/b>
\n\u4e2d\u7b49\u75c7\u60a3\u8005\u306b\u9650\u5b9a\u3057\u3066\u3001\u81e8\u5e8a\u56de\u5fa9\u7387\u30922\u5024\u5316\u3057\u3066\u5358\u7d14\u6bd4\u8f03\u3059\u308b\u3068\u3001\u8457\u8005\u304c\u767a\u8868\u3057\u3066\u3044\u308b\u3088\u3046\u306b\u7d71\u8a08\u7684\u306b\u3082\u6709\u610f\u3067\u3059\uff08RR= 1.28\uff1b\u30001.04-1.57\uff09\u3002
\n\u3057\u304b\u3057\u3001\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u89e3\u6790\u306f\u4e8b\u524d\u8a2d\u5b9a\u3055\u308c\u305f\u3082\u306e\u3067\u306f\u306a\u3044\u3067\u3059\u3002<\/p>\n

\u25cfRisk of bias<\/b>
\n\u3053\u306eRCT\u30a8\u30d3\u30c7\u30f3\u30b9\u306eRoB\u3092Cochrane RoB 2.0<\/a><\/b>\u3092\u4f7f\u3063\u3066\u8a55\u4fa1\u3059\u308b\u3068\u3001“High RoB”<\/b><\/span>\u3067\u3059\u3002<\/p>\n

*RoB table:<\/b><\/span>
\n\"\"<\/a><\/p>\n

*RoB_Summary:<\/b><\/span>
\nROB 2_summary_table<\/a><\/p>\n

\n

\u6ce8\uff1a\u3053\u308c\u3089\u306e\u8a55\u4fa1\u306f\u500b\u4eba\u7684\u306b\u5b9f\u65bd\u3057\u305f\u3082\u306e\u3067\u3001\u6b63\u78ba\u6027\u306f\u4fdd\u8a3c\u3067\u304d\u307e\u305b\u3093\u3002<\/p>\n<\/div>\n

\n <\/p>\n","protected":false},"excerpt":{"rendered":"

\u30a2\u30d3\u30ac\u30f3\u306b\u3064\u3044\u3066\u8cdb\u5426\u4e21\u8ad6\u304c\u3042\u308a\u307e\u3059\u304c\u3001COVID-19\u60a3\u8005\u306b\u304a\u3051\u308b\u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a13\u306f\u3001\u73fe\u72b6\u3067\u306f\u4ee5\u4e0b\u306e\u307f\u3067\u3059\u3002 Favipiravir versus Arbidol for COVID-19: A Randomized […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[470],"tags":[],"_links":{"self":[{"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/posts\/10339"}],"collection":[{"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=10339"}],"version-history":[{"count":29,"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/posts\/10339\/revisions"}],"predecessor-version":[{"id":10374,"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/posts\/10339\/revisions\/10374"}],"wp:attachment":[{"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=10339"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=10339"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=10339"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}