{"id":108,"date":"2008-08-25T14:45:34","date_gmt":"2008-08-25T05:45:34","guid":{"rendered":"http:\/\/aihara.la.coocan.jp\/blog\/?p=108"},"modified":"2014-04-16T15:34:55","modified_gmt":"2014-04-16T06:34:55","slug":"%e8%87%a8%e5%ba%8a%e8%a9%a6%e9%a8%93%e3%81%aeadaptive-design","status":"publish","type":"post","link":"http:\/\/aihara.la.coocan.jp\/?p=108","title":{"rendered":"\u81e8\u5e8a\u8a66\u9a13\u306eadaptive design"},"content":{"rendered":"
\n

\u30d9\u30a4\u30ba\u7d71\u8a08\u306e\u6d41\u884c\u3068\u3068\u3082\u306b\u3001adaptive design<\/b>\u306e\u81e8\u5e8a\u8a66\u9a13\u304c\u591a\u304f\u306a\u3063\u3066\u304d\u3066\u3044\u308b\u3002
\nadaptive design\u3001\u3059\u306a\u308f\u3061\u30c7\u30fc\u30bf\u4f9d\u5b58\u7684\u306b\u30c7\u30b6\u30a4\u30f3\u3092\u67d4\u8edf\u306b\u8003\u3048\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3001\u5177\u4f53\u7684\u306b\u306f\u3001\u7d71\u8a08\u5b66\u306e\u5927\u6a4b\u9756\u96c4\u6559\u6388\u306e\u5206\u985e\u8aac\u660e\u3067\u306f\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u3082\u306e\u306e\u3088\u3046\u3067\u3042\u308b\u3002
\n—————————————————–
\n\u25cf<\/b> \u60a3\u8005\u5272\u308a\u4ed8\u3051\u78ba\u7387\u306e\u5909\u66f4
\n\u25cf<\/b> \u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u306e\u5909\u66f4
\n\u25cf<\/b> \u9010\u6b21\u8a66\u9a13\u3068\u65e9\u671f\u8a66\u9a13\u4e2d\u6b62
\n\u25cf<\/b> \u610f\u5fd7\u6c7a\u5b9a\u898f\u5247\u306e\u5909\u66f4\uff08\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306e\u5909\u66f4\u306a\u3069\uff09
\n\u25cf<\/b> \u5bfe\u8c61\u96c6\u56e3\u306e\u5909\u66f4
\n\u25cf<\/b> \u9069\u5fdc\u7684\u7528\u91cf\u8a2d\u5b9a\u8a66\u9a13
\n\u25cf<\/b> \u30b7\u30fc\u30e0\u30ec\u30b9 II\/III\u8a66\u9a13\uff08IIB\u3068III\u76f8\u8a66\u9a13\u3092\u5207\u308c\u76ee\u7121\u304f\u5b9f\u65bd\u3001\u306a\u3069\uff09
\n—————————————————–<\/p>\n

<\/p>\n

GRADE \u30b7\u30b9\u30c6\u30e0<\/b><\/a>\u306e\u8996\u70b9\u3067\u3053\u306e\u3088\u3046\u306a\u81e8\u5e8a\u8a66\u9a13\u3092\u8a55\u4fa1\u3059\u308b\u3068\u3001\u591a\u304f\u306f\u3001limitations<\/b>\u306e\u5224\u5b9a\u57fa\u6e96\u3067\u8cea\u306e\u4f4e\u4e0b\u306b\u3064\u306a\u304c\u308b\u3082\u306e\u3067\u3042\u308b\u3002<\/p>\n

<\/p>\n

\u8907\u6570\u306e\u540c\u3058\u3088\u3046\u306a\u8a66\u9a13\u3092\u7d71\u5408\u3057\u3066\u306e\u8a55\u4fa1\u3068\u3057\u3066\u3082\u3001very serous limitations<\/b>\u306e\u5927\u898f\u6a21\u8a66\u9a13\u7d50\u679c\u304b\u3089\u5f97\u3089\u308c\u305f\u30a8\u30d3\u30c7\u30f3\u30b9\u306f\u3001very low quality\u3001GRADE\uff1dD<\/b>\u306e\u5224\u5b9a\u3068\u306a\u308b\u3002
\n\u76ee\u306e\u524d\u306e\u60a3\u8005\u306b\u3001\u305d\u306e\u3088\u3046\u306a\u7814\u7a76\u7d50\u679c\u304b\u3089\u5f97\u3089\u308c\u305f\u30a8\u30d3\u30c7\u30f3\u30b9\u306b\u57fa\u3065\u3044\u305f\u4ecb\u5165\u3092\u3001\u63a8\u5968\u3059\u308b\u3060\u308d\u3046\u304b\u3068\u8003\u3048\u308b\u3068\u3001\u305d\u308c\u306f\u6c7a\u3057\u3066strong recommendation<\/b>\u306b\u306f\u306a\u3089\u306a\u3044\u3067\u3042\u308d\u3046\u3002<\/p>\n

<\/p>\n

\u7a2e\u3065\u3051\u8a66\u9a13\uff08seeding trial\uff09<\/b>\u306f\u3001\u627f\u8a8d\u5be9\u67fb\u4e2d\u307e\u305f\u306f\u627f\u8a8d\u3055\u308c\u3066\u9593\u3082\u306a\u3044\u85ac\u5264\u306e\u4f7f\u7528\u3092\u63a8\u5968\u3059\u308b\u76ee\u7684\u3067\u88fd\u85ac\u4f1a\u793e\u304c\u30c7\u30b6\u30a4\u30f3\u3057\u305f\u81e8\u5e8a\u8a66\u9a13\u3067\u3042\u308b\u304c\u3001\u81e8\u5e8a\u306e\u6700\u524d\u7dda\u3067\u306e\u6cbb\u7642\u4ecb\u5165\u306b\u304a\u3044\u3066\u3001\u30aa\u30ea\u30b8\u30ca\u30eb\u306e\u8a66\u9a13\u306e\u4fe1\u983c\u6027\uff08validity)\u306b\u6ce8\u610f\u3057\u306a\u3044\u3068\u3001benefits\/downsides (risk, burden, cost) \u30d0\u30e9\u30f3\u30b9\u8a55\u4fa1\u3092\u8aa4\u308b\u3053\u3068\u306b\u3064\u306a\u304c\u308a\u3084\u3059\u3044\u3002<\/p>\n

<\/p>\n

adaptive design\u306e\u5206\u985e\u3068\u7528\u8a9e\uff1a<\/b>
\n\"adaptive\"<\/a>\n<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u30d9\u30a4\u30ba\u7d71\u8a08\u306e\u6d41\u884c\u3068\u3068\u3082\u306b\u3001adaptive design\u306e\u81e8\u5e8a\u8a66\u9a13\u304c\u591a\u304f\u306a\u3063\u3066\u304d\u3066\u3044\u308b\u3002 adaptive design\u3001\u3059\u306a\u308f\u3061\u30c7\u30fc\u30bf\u4f9d\u5b58\u7684\u306b\u30c7\u30b6\u30a4\u30f3\u3092\u67d4\u8edf\u306b\u8003\u3048\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3001\u5177\u4f53\u7684\u306b\u306f\u3001\u7d71\u8a08\u5b66\u306e\u5927\u6a4b\u9756\u96c4\u6559\u6388\u306e\u5206\u985e\u8aac […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[3,140],"tags":[49,142,141],"_links":{"self":[{"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/posts\/108"}],"collection":[{"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=108"}],"version-history":[{"count":1,"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/posts\/108\/revisions"}],"predecessor-version":[{"id":574,"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/posts\/108\/revisions\/574"}],"wp:attachment":[{"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=108"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=108"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=108"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}