{"id":11378,"date":"2020-10-30T16:37:12","date_gmt":"2020-10-30T07:37:12","guid":{"rendered":"http:\/\/aihara.la.coocan.jp\/?p=11378"},"modified":"2020-10-30T16:39:46","modified_gmt":"2020-10-30T07:39:46","slug":"covid-19%ef%bc%88%e9%87%8d%e7%97%87%e5%ba%a6%e5%88%a5%ef%bc%89%e3%81%ae%e8%96%ac%e7%89%a9%e6%b2%bb%e7%99%82","status":"publish","type":"post","link":"http:\/\/aihara.la.coocan.jp\/?p=11378","title":{"rendered":"COVID-19\uff08\u91cd\u75c7\u5ea6\u5225\uff09\u306e\u85ac\u7269\u6cbb\u7642\uff1a\u4e88\u6e2c\u533a\u9593\u3092\u4f7f\u3063\u3066\u30fb\u30fb"},"content":{"rendered":"

\u65e5\u672c\u7248\u6557\u8840\u75c7\u8a3a\u7642\u30ac\u30a4\u30c9\u30e9\u30a4\u30f32020\uff08J-SSCG2020\uff09\u7279\u5225\u7de8COVID-19\u85ac\u7269\u7642\u6cd5\u306b\u95a2\u3059\u308bRapid\/Living recommendations\u306b\u304a\u3051\u308b\u8907\u6570\u306e\u30a2\u30a6\u30c8\u30ab\u30e0\u306b\u308f\u305f\u308b\u6b63\u5473\u306e\u52b9\u679c\u63a8\u5b9a\u5024\uff08Net Effect Estimate\uff09\u306e\u8003\u3048\u65b9\u3092\u8aac\u660e\u3057\u307e\u3057\u305f\u3002<\/p>\n

http:\/\/aihara.la.coocan.jp\/?p=11165<\/b><\/a><\/p>\n

\n

(Alper. Defining certainty of net benefit: a GRADE concept paper. BMJ Open2019;9:e027445<\/b><\/a>.\uff09<\/p>\n<\/div>\n

\u3067\u306f\u3001\u3053\u306e\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3067\u53d6\u308a\u4e0a\u3052\u3066\u3044\u308b\u85ac\u7269\u6cbb\u7642\u306b\u95a2\u3059\u308b\u30c7\u30fc\u30bf\u3092\u6d3b\u7528\u3057\u3066\u3001\u6b63\u5473\u306e\u52b9\u679c\uff08Net effect\uff09\u3092COVID-19\u306e\u91cd\u75c7\u5ea6\u5225\u306b\u6bd4\u8f03\u3059\u308b\u3068\u3069\u3046\u306a\u308b\u304b\u3092\u8abf\u3079\u308b\u3068\u4ee5\u4e0b\u306e\u7d50\u679c\u3067\u3059\u3002<\/p>\n\n\n
\n\u25cfCOVID-19\u91cd\u75c7\u5ea6\uff1a<\/b>\u8efd\u75c7\u3001\u4e2d\u7b49\u75c7\u3001\u91cd\u75c7\u306e3\u6bb5\u968e\uff08J-SSCG2020\u7279\u5225\u7de8COVID-19\u85ac\u7269\u7642\u6cd5\u306b\u95a2\u3059\u308bRapid\/Living recommendations\uff09<\/p>\n

\u25cf\u4ecb\u5165\uff08\u63a1\u7528\u85ac\u7269\u6cbb\u7642A\uff09\uff1a<\/b>Favipiravir\u3001Remdesivir\u3001Dexamethasone\uff08\u5bfe\u8efd\u75c7\u4f8b\u306f\u9664\u5916\uff09\u3001Tocilizumab\u3001
\n*\uff08\u9664\u5916\u6cbb\u7642\uff09\uff1aDexamethasone\uff08\u5bfe\u8efd\u75c7\u4f8b\uff09\u3001Hydroxychloroquine<\/p>\n

\u25cf\u6bd4\u8f03\u5bfe\u7167\uff1a<\/b>\u6a19\u6e96\u6cbb\u7642\u307e\u305f\u306f\u30d7\u30e9\u30bb\u30dc<\/p>\n

\u25cf\u30a2\u30a6\u30c8\u30ab\u30e0\uff1a<\/b>\u5168\u539f\u56e0\u6b7b\u4ea1\u3001\u81e8\u5e8a\u56de\u5fa9\u3001\u6df1\u523b\u306a\u6709\u5bb3\u4e8b\u8c613\u500b\u306eNet Effect Estimate
\n*\u30a2\u30a6\u30c8\u30ab\u30e0\u30c7\u30fc\u30bf\u306f\u3001J-SSCG2020\u7279\u5225\u7de8COVID-19\u85ac\u7269\u7642\u6cd5\u306b\u95a2\u3059\u308bRapid\/Living recommendations\u7b2c2\u7248\u3088\u308a\u3002
\n*\u30a2\u30a6\u30c8\u30ab\u30e0\u6307\u6a19\u306f\u30ea\u30b9\u30af\u5dee[RD]\u3067\u3001\u30d7\u30e9\u30b9\u304c\u6709\u76ca\u52b9\u679c\n<\/td>\n<\/tr>\n<\/table>\n

\n 
\n<\/p>\n

\n

\u25a0\u7d50\u679c<\/b><\/span><\/p>\n<\/div>\n

************************
\n\"\"<\/a>
\n
\n 
\n
\n1.\u8efd\u75c7\u4f8b\u3001\u4e2d\u7b49\u75c7\u4f8b\u3001\u91cd\u75c7\u4f8b\u3044\u305a\u308c\u3082\u3001\u85ac\u7269\u6cbb\u7642\u306b\u3088\u308b\u6709\u76ca\u52b9\u679c\u304c\u3042\u308a\u3001\u52b9\u679c\u306e\u5927\u304d\u3055\u3068\u3057\u3066\u306f\u304a\u3088\u305d100\/1000\u4eba\u3067\u3042\u308b\u3002<\/p>\n

2.\u3057\u304b\u3057\u3001\u8efd\u75c7\u4f8b\u306b\u304a\u3051\u308bFavipiravir\u306e\u52b9\u679c\u63a8\u5b9a\u5024\u306f\u4e0d\u7cbe\u78ba\u3067\u3001\u52b9\u679c\u306a\u3057\u306e\u30e9\u30a4\u30f3\u3092\u307e\u305f\u3044\u3067\u3044\u308b\u3082\u306e\u306e\u3001\u6709\u5bb3\u3068\u3059\u308b\u63a8\u5968\u95be\u5024\u306f\u307e\u305f\u3044\u3067\u3044\u306a\u3044\u53ef\u80fd\u6027\u304c\u9ad8\u3044\u3002<\/p>\n

3\uff0e\u4e00\u65b9\u3001\u4e2d\u7b49\u75c7\u4f8b\u306b\u304a\u3044\u3066\u306f\u3001\uff13\u7a2e\u985e\u306e\u85ac\u7269\u306e\u7d71\u5408\u63a8\u5b9a\u5024\u306f95%\u4fe1\u983c\u533a\u9593\uff08CI\uff09\u304b\u3089\u306f\u4e0d\u7cbe\u78ba\u3055\u306f\u306a\u3044\u3082\u306e\u306e\u300195%\u4e88\u6e2c\u533a\u9593\uff08PrI\uff09\u306f\u975e\u5e38\u306b\u5e45\u304c\u5e83\u304f\u3001\u6709\u5bb3\u304a\u3088\u3073\u6709\u76ca\u306e\u63a8\u5968\u95be\u5024\u3092\u307e\u305f\u3044\u3067\u3044\u308b\uff08I2<\/sup>\u5024\u308260%\uff09\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u3053\u306e\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u306f\u7570\u8cea\u6027\u306b\u3088\u308b\u7b49\u7d1a\u30c0\u30a6\u30f3\uff08-2\uff09\u3068\u306a\u308b\u3002<\/p>\n

\uff14\uff0e\u91cd\u75c7\u4f8b\u3067\u306f\u30012\u7a2e\u985e\u306e\u85ac\u7269\u306b\u3088\u308b\u7d71\u5408\u63a8\u5b9a\u5024\u306f\u4e0d\u7cbe\u78ba\u3055\u306f\u306a\u304f\u3001I2<\/sup>\u5024\u306f0%\u3067\u7570\u8cea\u6027\u306f\u306a\u3044\u3002\u85ac\u7269\u52b9\u679c\u306f\u70b9\u63a8\u5b9a\u5024\u306f130\/1000\u3067\u3042\u308b\u3002\u4ecb\u5165\u6570\u304c\u5c11\u306a\u304f\u4e88\u6e2c\u533a\u9593\u306fStata\u3067\u306f\u8a55\u4fa1\u3067\u304d\u306a\u3044\u305f\u3081\u3001pimeta(R) Randome-effects model\uff08parametric bootstrap\uff09\u3067\u8abf\u3079\u308b\u3068PrI\u306f\uff700.64\uff5e0.94\u3067\u3042\u308a\u3001\u7b49\u7d1a\u30c0\u30a6\u30f3\uff08-2\uff09\u3068\u306a\u308b\u3002<\/p>\n

5\uff0e\u5168\u4f53\u3068\u3057\u3066\u306e\u7d71\u5408\u52b9\u679c\u306f\u3001RD=0.09 (0.05\uff5e0.13)\u3067\u3042\u308a\u300195%CI\u304b\u3089\u4e0d\u7cbe\u78ba\u3055\u306f\u306a\u304f\u300195%CrI\uff080\uff5e0.17\uff09\u304b\u3089\u7570\u8cea\u6027\u3082\u306a\u304f\u3001\u7b49\u7d1a\u30c0\u30a6\u30f3\u306a\u3057\u3002
\n\uff08\u4ee5\u4e0b\u306e\u3088\u3046\u306b\u3001parametric bootstrap approach<\/span>(*ref)\u3067\u306f\u300195%prI=-0.03\uff5e0.24\uff09<\/b><\/p>\n

\n

*ref:Nagashima K, Noma H, Furukawa TA. Prediction intervals for random-effects meta-analysis: a confidence distribution approach. Stat Methods Med Res. 2019 Jun;28(6):1689-1702<\/a><\/p>\n<\/div>\n

\n <\/p>\n

\n

\u25a0\u7d50\u8ad6<\/b><\/span><\/p>\n<\/div>\n

COVID-19\u60a3\u8005\u306b\u5bfe\u3057\u3066\u306f\u3001\u85ac\u7269\u6cbb\u7642\u306e\u5b9f\u65bd\u3092\u63d0\u6848\u3059\u308b\u3002<\/b>
\n
\n <\/p>\n

\n

\u25a0parametric bootstrap approach<\/b><\/span><\/p>\n<\/div>\n

\"\"<\/a><\/p>\n

\n <\/p>\n","protected":false},"excerpt":{"rendered":"

\u65e5\u672c\u7248\u6557\u8840\u75c7\u8a3a\u7642\u30ac\u30a4\u30c9\u30e9\u30a4\u30f32020\uff08J-SSCG2020\uff09\u7279\u5225\u7de8COVID-19\u85ac\u7269\u7642\u6cd5\u306b\u95a2\u3059\u308bRapid\/Living recommendations\u306b\u304a\u3051\u308b\u8907\u6570\u306e\u30a2\u30a6\u30c8\u30ab\u30e0\u306b\u308f\u305f\u308b\u6b63\u5473\u306e\u52b9\u679c\u63a8\u5b9a\u5024\uff08Net Effe […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[470,1],"tags":[],"_links":{"self":[{"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/posts\/11378"}],"collection":[{"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=11378"}],"version-history":[{"count":38,"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/posts\/11378\/revisions"}],"predecessor-version":[{"id":11421,"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/posts\/11378\/revisions\/11421"}],"wp:attachment":[{"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=11378"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=11378"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=11378"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}