{"id":2395,"date":"2015-09-10T11:12:41","date_gmt":"2015-09-10T02:12:41","guid":{"rendered":"http:\/\/aihara.la.coocan.jp\/?p=2395"},"modified":"2015-09-26T10:05:15","modified_gmt":"2015-09-26T01:05:15","slug":"%e3%80%8cgrade%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8bevidence%e8%a9%95%e4%be%a1%e3%81%a8%e4%bc%9d%e7%b5%b1%e5%8c%bb%e5%ad%a6%e3%80%8d%e3%81%ae%e8%aa%a4%e8%a7%a3","status":"publish","type":"post","link":"http:\/\/aihara.la.coocan.jp\/?p=2395","title":{"rendered":"\u300cGRADE\u306b\u304a\u3051\u308bevidence\u8a55\u4fa1\u3068\u4f1d\u7d71\u533b\u5b66\u300d\u306e\u8aa4\u89e3"},"content":{"rendered":"

\u4ee5\u4e0b\u306f\u5ca9\u5d0e\u92fc\u5148\u751f\uff08\u6771\u5317\u5927\u5b66\u5927\u5b66\u9662\u533b\u5b66\u7cfb\u7814\u7a76\u79d1\u30fb\u533b\u5b66\u90e8\uff09\u306eFB\u306b\u304a\u3051\u308b\u8a18\u4e8b\uff082015\/9\/9\uff09\u3067\u3059\u3002\u3053\u306e\u5185\u5bb9\u306b\u306f\u3001GRADE\u306b\u95a2\u3059\u308b\u57fa\u672c\u7684\u306a\u8aa4\u89e3\u3084\u3001GRADE\u9069\u7528\u524d\u306e\u5224\u65ad\u306e\u8aa4\u89e3\u304c\u3042\u308a\u307e\u3059\u3002\u8ee2\u8f09\u53ef\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u306e\u3067\u3001\u305d\u306e\u51fa\u5178\u3092\u660e\u8a18\u3057\u3066\u7d39\u4ecb\u3057\u3001\u3069\u3053\u304c\u304a\u304b\u3057\u3044\u306e\u304b\u3092\u7c21\u5358\u306b\u8aac\u660e\u3057\u307e\u3059\u3002<\/p>\n

<\/p>\n

\n

GRADE\u306b\u304a\u3051\u308bevidence\u8a55\u4fa1\u3068\u4f1d\u7d71\u533b\u5b66<\/b><\/a>\uff08\u5ca9\u5d0e\uff1a\u8ee2\u8f09\u53ef\u3001\u4f46\u3057\u51fa\u5178\u3092\u793a\u3059\u3053\u3068\uff09<\/p>\n<\/div>\n

<\/p>\n\n\n
\n

\u65e2\u306b\u4f55\u5ea6\u304b\u8ff0\u3079\u305f\u3088\u3046\u306b\u3001The Grading of Recommendations Assessment, Development and Evaluation (GRADE) system \u3067\u306fQuality of Evidence (QoE)\u3068Recommendation Strength (RS)\u3068\u3044\u3046\u4e8c\u3064\u306e\u89b3\u70b9\u304b\u3089\u6cbb\u7642\u6cd5\u3092\u691c\u8a0e\u3059\u308b\u3002\u5f93\u6765\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u30fb\u30d2\u30a8\u30e9\u30eb\u30d2\u30fc\u304c\u3082\u3063\u3071\u3089\u30a8\u30d3\u30c7\u30f3\u30b9\u306e\u8cea\u3060\u3051\u3092\u8a55\u4fa1\u3057\u3066\u3044\u305f\u306e\u306b\u6bd4\u3079\u308b\u3068\u3001RS\u304c\u65b0\u305f\u306b\u8ffd\u52a0\u3055\u308c\u3066\u3044\u308b\u3002<\/p>\n

\u3057\u304b\u3057\u3001RS\u306b\u3064\u3044\u3066\u306f\u307e\u3060\u65b0\u3057\u3044\u6982\u5ff5\u3067\u3042\u308a\u3001\u56fa\u307e\u3063\u3066\u3044\u306a\u3044\u90e8\u5206\u3082\u3042\u308a\u3001\u307e\u305f\u305d\u306e\u8a55\u4fa1\u306f\u6975\u3081\u3066\u96e3\u3057\u3044\u3002\u7279\u306b\u3001\u9ad8\u9f62\u8005\u533b\u7642\u3084\u6f22\u65b9\u306a\u3069\u5e45\u5e83\u3044\u9818\u57df\u3092\u6271\u3046\u5834\u5408\u3001\u3053\u308c\u3092\u5b9f\u969b\u8a55\u4fa1\u3059\u308b\u306e\u306f\u304b\u306a\u308a\u56f0\u96e3\u3067\u3042\u308b\u3002<\/p>\n

\u305d\u3053\u3067\u3053\u3053\u3067\u306f\u3001QoE\u306b\u9650\u3063\u3066\u3001\u3042\u308b\u6709\u540d\u306a\u65b9\u5264\u3092\u4f8b\u306b\u3068\u3063\u3066\u8003\u3048\u3066\u307f\u305f\u3044\u3002\u91e3\u85e4\u6563\u3067\u3042\u308b\u3002<\/p>\n

GRADE\u306fRCT\u3067\u306a\u3044case series\u3092\u3082\u8a55\u4fa1\u306e\u5bfe\u8c61\u3068\u3059\u308b\u304c\u3001\u3053\u3053\u3067\u306f\u7d19\u9762\u306e\u95a2\u4fc2\u4e0a\u3001RCT\u4ee5\u4e0a\u306b\u9650\u3063\u3066\u306e\u3079\u308b\u3002\u91e3\u85e4\u6563\u306b\u306f\u3001\u8a8d\u77e5\u75c7\u3092\u5bfe\u8c61\u3068\u3057\u305fDB-RCT\u304c\u4e8c\u3064\u5b58\u5728\u3059\u308b\u306e\u3067\u3001\u305d\u308c\u3092\u8a55\u4fa1\u3057\u3088\u3046\u3068\u3044\u3046\u308f\u3051\u3067\u3042\u308b\u3002<\/p>\n

GRADE\u306b\u3088\u308c\u3070\u3001RCT\u4ee5\u4e0a\u306e\u7814\u7a76\u306eQoE\u306f\u521d\u3081\u306fhigh\u304b\u3089\u8a55\u4fa1\u304c\u30b9\u30bf\u30fc\u30c8\u3059\u308b\u3002\u3057\u304b\u3057\u3001\u3053\u3053\u3067QoE\u3092\u4e0b\u3052\u308b5\u3064\u306e\u8981\u56e0\u3092\u8003\u616e\u305b\u306d\u3070\u306a\u3089\u306a\u3044\uff08RCT\u3067\u306a\u3044\u5834\u5408\u306f\u3001\u4ed6\u306b\u4e0a\u3052\u308b\u8981\u56e0\u3001\u3068\u3044\u3046\u3082\u306e\u3082\u3042\u308b\u304c\u3053\u3053\u3067\u306f\u8ff0\u3079\u306a\u3044\uff09\u3002<\/p>\n

\n1.Limitations (\u30d0\u30a4\u30a2\u30b9\u30ea\u30b9\u30af)\uff1a\u30c7\u30b6\u30a4\u30f3\u304c\u4e0d\u9069\u5207\u3001masking\u304c\u6210\u3055\u308c\u3066\u3044\u306a\u3044\u306a\u3069\u7814\u7a76\u624b\u6cd5\u4e0a\u306e\u554f\u984c
\n2.inconsistency\uff08\u975e\u4e00\u8cab\u6027\uff09\uff1a\u8907\u6570\u306e\u540c\u3058RQ\u306e\u7814\u7a76\u304c\u3042\u308b\u5834\u5408\u3001\u7814\u7a76\u306b\u3088\u3063\u3066\u7d50\u679c\u304c\u7570\u306a\u308b
\n3. indirectness\uff08\u975e\u76f4\u63a5\u6027\uff09\uff1a\u77e5\u308a\u305f\u3044\u3053\u3068\u3068\u7814\u7a76\u7d50\u679c\u304c\u4e00\u81f4\u3057\u306a\u3044\u3002
\n4.imprecision\uff08\u4e0d\u7cbe\u78ba\u3055\uff09\uff1a\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u306e\u4e0d\u8db3\u306a\u3069\u3067\u7814\u7a76\u306e\u7cbe\u78ba\u6027\u306b\u7591\u554f\u304c\u3042\u308b\u3002
\n5.publication bias\uff08\u51fa\u7248\u30d0\u30a4\u30a2\u30b9\uff09\uff1a\u90fd\u5408\u306e\u3088\u3044\u30c7\u30fc\u30bf\u3060\u3051\u304c\u51fa\u7248\u3055\u308c\u305f\u3001\u3042\u308b\u3044\u306f\u51fa\u7248\u306b\u4f55\u3089\u304b\u306e\u504f\u308a\u304c\u3042\u308b<\/p>\n

GRADE\u3067\u306f\u3053\u308c\u3089\u3092\u5143\u306b\u3057\u3066\u3001QoE\u3092high, moderate, low, very low\u306b\u5206\u985e\u3059\u308b\u3002\u3067\u306f\u3001\u3053\u308c\u3092\u7528\u3044\u3066\u91e3\u85e4\u6563\u306e\u8133\u8840\u7ba1\u6027\u8a8d\u77e5\u75c7\u306b\u5bfe\u3059\u308b\u52b9\u679c\u3092\u691c\u8a3c\u3057\u3066\u307f\u3088\u3046\u3002<\/p>\n

\u91e3\u85e4\u6563\u306f\u6211\u304c\u56fd\u306e\u533b\u7642\u7528\u6f22\u65b9\u88fd\u5264\u306e\u4e00\u3064\u3067\u3042\u308a\u3001\u8133\u8840\u7ba1\u6027\u969c\u5bb3\u5f8c\u907a\u75c7\u3068\u3057\u3066\u306eADL\u6539\u5584\u3092\u793a\u5506\u3059\u308b\uff12\u672c\u306eDB-RCT(\u4e0b\u8a181,2)\u3092\u6709\u3057\u3001\u307e\u305f\u85ac\u7406\u6a5f\u5e8f\u306b\u95a2\u3057\u3066\u3082\u591a\u304f\u306e\u5831\u544a\u304c\u3042\u308b\u3002\u6587\u732e1\u306f\u3001\u4f1d\u7d71\u533b\u5b66\u3068\u3057\u3066\u4e16\u754c\u3067\u59cb\u3081\u3066\u884c\u308f\u308c\u305fDB-RCT\u3067\u3042\u308a\u3001\u305d\u306e\u533b\u53f2\u5b66\u7684\u4fa1\u5024\u306f\u8a08\u308a\u77e5\u308c\u306a\u3044\u3002<\/p>\n

\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u4ecaGRADE\u30b7\u30b9\u30c6\u30e0\u306b\u7167\u3089\u3057\u3066\u305d\u306e\u5185\u5bb9\u3092\u8a55\u4fa1\u3059\u308b\u3068\u3001\u307e\u305a\u30e9\u30f3\u30c0\u30e0\u5316\u304c\u5c01\u7b52\u6cd5\u3067\u3042\u308b\u3053\u3068\u304c\u30d0\u30a4\u30a2\u30b9\u30ea\u30b9\u30af\u306b\u8a72\u5f53\u3057\u3001\u9069\u5207\u306asample size estimation\u308495%CI\u304c\u8a18\u8f09\u3055\u308c\u3066\u5c45\u306a\u3044\u3053\u3068\u306f\u4e0d\u7cbe\u78ba\u6027\u306b\u8a72\u5f53\u3059\u308b\u3002\u3055\u3089\u306b\u3001RQ\u304c\u8a8d\u77e5\u6a5f\u80fd\u306b\u5bfe\u3059\u308b\u52b9\u679c\u3092\u89b3\u308b\u3082\u306e\u3067\u3042\u3063\u305f\u306e\u306b\u5bfe\u3057\u3001\u7d50\u679c\u7684\u306b\u6709\u610f\u5dee\u304c\u898b\u3089\u308c\u305f\u306e\u306fADL, BPSD\u306b\u8a72\u5f53\u3059\u308b\u9805\u76ee\u3067\u3042\u3063\u305f\u3053\u3068\u306f\u3001\u975e\u76f4\u63a5\u6027\u306b\u8a72\u5f53\u3059\u308b\u3002\u3053\u308c\u3089\u3092\u7dcf\u5408\u3059\u308b\u3068\u3001DB-RCT\u3067\u3042\u308b\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001GRADE\u57fa\u6e96\u306b\u3088\u308bQoE\u306fvery low\u3068\u306a\u308b\u3002<\/p>\n

\u6587\u732e2\u3082DB-RCT\u3067\u3042\u308b\u304c\u3001\u8a8d\u77e5\u75c7\u306e\u4e2d\u6838\u75c7\u72b6\u3067\u3042\u308b\u8a8d\u77e5\u6a5f\u80fd\u3092\u8a55\u4fa1\u3057\u305f\u7814\u7a76\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u7570\u306a\u308b\u75be\u60a3\u7fa4\uff08\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3001\u8133\u8840\u7ba1\u6027\u8a8d\u77e5\u75c7\u306a\u3069\uff09\u3092\u533a\u5225\u305b\u305a\u5bfe\u8c61\u3068\u3057\u3066\u304a\u308a\u3001\u75be\u60a3\u6bce\u306e\u30b5\u30d6\u89e3\u6790\u3082\u884c\u308f\u308c\u3066\u3044\u306a\u3044\u3002\u3053\u308c\u306fGRADE\u57fa\u6e96\u3067\u8a00\u3048\u3070\u975e\u76f4\u63a5\u6027\u306b\u8a72\u5f53\u3059\u308b\u4e0a\u3001\u305d\u3082\u305d\u3082\u5bfe\u7167\u7fa4\u306e\u9078\u629e\u304c\u533b\u5b66\u7684\u306b\u59a5\u5f53\u6027\u3092\u6b20\u304f\u305f\u3081\u3001limitation\u3082\u6307\u6458\u3067\u304d\u308b\u3002\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3053\u306e\u6587\u732e\u304cJournal of the American Geriatrics Society\u306b\u63b2\u8f09\u3055\u308c\u305f\u3053\u3068\u306b\u3064\u3044\u3066\u306f\u3001peer review\u3092\u7d4c\u306a\u3044\u30ec\u30bf\u30fc\u3067\u3042\u3063\u305f\u305f\u3081\u3001\u51fa\u7248\u30d0\u30a4\u30a2\u30b9\u3082\u751f\u3058\u305f\u3068\u5224\u65ad\u305b\u3056\u308b\u3092\u5f97\u306a\u3044\u3002\u3088\u3063\u3066\u3053\u306e\u8ad6\u6587\u306eQoE\u306f\u3084\u306f\u308avery low\u3067\u3042\u308b\u3002<\/p>\n

\u4ee5\u4e0a\u3092\u52d8\u6848\u3059\u308b\u3068\u3001\u91e3\u85e4\u6563\u306e\u8133\u8840\u7ba1\u6027\u8a8d\u77e5\u75c7\u6539\u5584\u52b9\u679c\u306eQoE\u306f\u4e0d\u5145\u5206\u3067\u3042\u308b\u3002\u3053\u306e\u3088\u3046\u306b\u3001\u4e16\u754c\u3067\u59cb\u3081\u3066\u4f1d\u7d71\u533b\u5b66\u306b\u95a2\u3057\u3066\u884c\u308f\u308c\u305fDB-RCT\u3092\u6709\u3059\u308b\u91e3\u85e4\u6563\u3068\u3044\u3048\u3069\u3082\u3001GRADE\u306b\u65bc\u3051\u308bQoE\u8a55\u4fa1\u306f\u6700\u4f4e\u30e9\u30f3\u30af\u306e\u300cvery low\u300d\u3068\u306a\u3063\u3066\u3057\u307e\u3046\u306e\u3067\u3042\u308b\u3002<\/p>\n

\u4f1d\u7d71\u533b\u5b66\u306b\u3064\u3044\u3066RS\u304c\u4e00\u5f8b\u306b\u8a55\u4fa1\u3067\u304d\u308b\u304b\u3069\u3046\u304b\u306f\u3001\u6975\u3081\u3066\u96e3\u3057\u3044\u554f\u984c\u304c\u3042\u308b\u3002\u3057\u304b\u3057\u4eca\u5f8c\u4f1d\u7d71\u533b\u5b66\u306b\u65bc\u3044\u3066\u3082\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306a\u3069\u3092\u4f5c\u6210\u3059\u308b\u306b\u5f53\u305f\u3063\u3066\u3001\u5c11\u306a\u304f\u3068\u3082QoE\u306b\u95a2\u3057\u3066\u306f\u3001\u52d8\u6848\u305b\u3056\u308b\u3092\u5f97\u306a\u3044\u3067\u3042\u308d\u3046\u3002\u4eca\u5f8c\u65e5\u672c\u6f22\u65b9\u3001\u4e2d\u533b\u5b66\u3068\u3082\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3092\u4f5c\u308b\u3068\u3044\u3046\u52d5\u304d\u304c\u51fa\u3066\u304d\u3066\u3044\u308b\u304c\u3001\u3053\u306e\u70b9\u3092\u3088\u304f\u8003\u616e\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u3002<\/p>\n

\u91e3\u85e4\u6563\u8ad6\u6587<\/p>\n

1.Choto-san in the treatment of vascular dementia: a double-blind, placebo-controlled study. Terasawa K; Shimada Y; Kita T; Goto S; Mizushima N; Fujioka M; Takase S; Seki H; Kimura I; Ogawa T; Nakamura S; Araki G; Maruyama I; Maruyama Y; Takori S. Phytomedicine vol4(1) 15-22 (1997)<\/p>\n

2A Chinese herbal medicine, choto-san, improves cognitive function and activities of daily living of patients with dementia: a double-blind, randomized, placebo-controlled study. Suzuki T; Futami S; Igari Y; Matsumura N; Watanabe K; Nakano H; Oba K; Murata Y; Koibuchi H; Kigawa Y. Journal of the American Geriatrics Society 53(12) Page:2238-40 (2005)<\/p>\n<\/td>\n<\/tr>\n<\/table>\n

\n <\/p>\n

GRADE\u306e\u3001Weak recommendation\u306e”weak\u201d\u306f\u3001\u8aa4\u89e3\u3055\u308c\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3088\u3046\u3060<\/b><\/a>(FB@8\/31)\u306b\u304a\u3044\u3066\u3001\u56fd\u5185GRADE\u30e1\u30f3\u30d0\u30fc\u304c\u305f\u3068\u306e\u5927\u8ad6\u4e89\u306e\u7d50\u679c\u3092\u7d4c\u3066\u306e\u3053\u306e\u767a\u8a00\u306a\u306e\u3067\u3001\u3068\u3066\u3082\u6b8b\u5ff5\u3067\u3059\u3002<\/p>\n

\u4e0a\u8a18\u5185\u5bb9\u306e\u9593\u9055\u3044\u306e\u3044\u304f\u3064\u304b\u3092\u4ee5\u4e0b\u306b\u6307\u6458\u3057\u307e\u3059\u3002<\/span><\/p>\n

<\/p>\n\n\n
\n

GRADE\u306e\uff15\u8981\u56e0\u306e\u8aac\u660e\u3082\u4e0d\u9069\u5207\u306a\u70b9\u304c\u591a\u3005\u3042\u308a\u307e\u3059\u304c\u3001\u305d\u308c\u3089\u306f\u7121\u8996\u3057\u307e\u3059\u3002
\n\uff08\u4f8b\u3001publication bias\u3068selective outcome reporting bias\u306e\u533a\u5225\u304c\u3067\u304d\u3066\u3044\u307e\u305b\u3093\uff09<\/p>\n

\u6587\u732e\uff11\u306eQoE= very low, \u6587\u732e\uff12\u306eQoE= very low\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u304c\u3001GRADE\u306e\u4f7f\u3044\u65b9\u3092\u9593\u9055\u3063\u3066\u3044\u307e\u3059\u3002
\n\u9ad8\u9f62\u8005\u306e\u5b89\u5168\u306a\u85ac\u7269\u7642\u6cd5\u30ac\u30a4\u30c9\u30e9\u30a4\u30f32015\uff08\u6848\uff09\u3067\u3082\u3001\u540c\u69d8\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u3092\u3057\u305f\u3068\u5224\u65ad\u3057\u305f\u3088\u3046\u3067\u3059\u304c\u3001\u305d\u308c\u306f\u9593\u9055\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n

GRADE\u306f\u8907\u6570\u306e\u7814\u7a76\u306b\u308f\u305f\u308b\u5404\u30a2\u30a6\u30c8\u30ab\u30e0\u306b\u95a2\u3059\u308b\u30a8\u30d3\u30c7\u30f3\u30b9\u306e\u8cea\u3092\u8a55\u4fa1\u3059\u308b\u3082\u306e\u3067\u3001\u500b\u3005\u306e\u7814\u7a76\u306e\u8cea\u3092\u7b49\u7d1a\u3059\u308b\u3082\u306e\u3067\u306f\u306a\u3044\u3067\u3059\u3002
\n\uff08GRADE rates the quality of evidence for each outcome across studies rather than rating each study as a single unit\uff09<\/p>\n

\u5c01\u7b52\u6cd5\u306a\u306e\u3067\u3000high RoB\u3068\u3044\u3046\u5224\u5b9a\u3082\u3044\u3051\u307e\u305b\u3093\u3002<\/p>\n

\u51fa\u7248\u30d0\u30a4\u30a2\u30b9\u306b\u3064\u3044\u3066\u3082\u3001\u9078\u629e\u7684\u30a2\u30a6\u30c8\u30ab\u30e0\u5831\u544a\u30d0\u30a4\u30a2\u30b9\u3068\u306e\u533a\u5225\u304c\u3067\u304d\u3066\u3044\u307e\u305b\u3093\u3002\u201d\u3053\u306e\u6587\u732e\u304c\uff5e\uff5epeer review\u3092\u7d4c\u306a\u3044\u30ec\u30bf\u30fc\u3067\u3042\u3063\u305f\u305f\u3081\u3001\u51fa\u7248\u30d0\u30a4\u30a2\u30b9\u3082\u751f\u3058\u305f\u3068\u5224\u65ad\u305b\u3056\u308b\u3092\u5f97\u306a\u3044\u201d\u3068\u304b\u3001\u904e\u53bb\u306e\u201d\u81ea\u5206\u306e\u7814\u7a76\u306a\u306e\u3067\u3001\u500b\u4eba\u7684\u306b\u306fpublication bias\u306f\u3042\u308a\u5f97\u307e\u305b\u3093\u3068\u65ad\u8a00\u3067\u304d\u308b\u201d\u306a\u3069\u3068\u3044\u3046\u4e0d\u53ef\u89e3\u306a\u767a\u8a00\u3082\u9837\u3051\u307e\u3059\u3002
\n\uff08GRADE considers selective outcome reporting under risk of bias (study limitations) since it can be addressed in single studies.\uff09<\/p>\n

<\/p>\n

\u3064\u307e\u308a\u3001GRADE\u306e\u57fa\u672c\u3092\u8aa4\u3063\u3066\u89e3\u91c8\u3057\u3066\u3044\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002GRADE\u30b7\u30b9\u30c6\u30e0\u306b\u304a\u3051\u308b\u3055\u307e\u3056\u307e\u306a\u5b9a\u7fa9\u3092\u66f2\u89e3\u3057\u3066\u3001\u4e0a\u8a18\u306e\u3088\u3046\u306a\u767a\u8a00\u3084\u3001”GRADE\u306fimmature\u3067\u3042\u308b”\u3001”GRADE\u306e\u63a8\u5968\u8868\u306f\u9593\u9055\u3063\u3066\u304a\u308a\u8a02\u6b63\u3055\u308c\u308b\u3079\u304d\u3067\u3042\u308b”\u306a\u3069\u3068\u3044\u3046\u306e\u306f\u6df7\u4e71\u306e\u3082\u3068\u3067\u3059\u3002\u9ad8\u9f62\u8005\u306e\u5b89\u5168\u306a\u85ac\u7269\u7642\u6cd5\u30ac\u30a4\u30c9\u30e9\u30a4\u30f32015\uff08\u6848\uff09\u306e\u30d1\u30cd\u30eb\u4f1a\u8b70\u306b\u304a\u3044\u3066\u5927\u8ad6\u4e89\u304c\u304a\u304d\u305f\u3053\u3068\u3082\u7d0d\u5f97\u3067\u304d\u307e\u3059\u306d\u3002<\/p>\n

BMJ\u3082\u3057\u304f\u306fJCE\u30b7\u30ea\u30fc\u30ba\u3092\u8aad\u3093\u3060\u307b\u3046\u304c\u826f\u3044\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n

<\/p>\n

\u86c7\u8db3\u306a\u304c\u3089\u3001\uff08\u91e3\u85e4\u6563\u306e\u52b9\u679c\u3092\u5426\u5b9a\u3059\u308b\u3064\u3082\u308a\u306f\u5168\u304f\u306a\u3044\u3067\u3059\u304c\uff09\u3001\u533b\u53f2\u5b66\u7684\u4fa1\u5024\u304c\u8a08\u308a\u77e5\u308c\u306a\u3044\u6587\u732e\uff11\u306f\u3001\u7dcf\u6570139\u4f8b\uff08CS 69\u4f8b vs \u5bfe\u716770\u4f8b\uff09\u3067\u30b9\u30bf\u30fc\u30c8\u3057\u3001\u89e3\u6790\u6642\u306f\u305d\u308c\u305e\u308c59\u4f8b\u306860\u4f8b\u3067\u3001ITT\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u307e\u305f\u3001\u6587\u732e\uff12\u306f\u3001\u7dcf\u657020\u4f8b\uff08CS\u7fa4\u3068\u5bfe\u7167\u7fa4\u306f\u3044\u305a\u308c\u308210\u4f8b\uff09\u3060\u3051\u3067\u3059\u3002GRADE\u3092\u4f7f\u3046\u3068\u3001\u3053\u306e\u3088\u3046\u306a\u30c7\u30fc\u30bf\u306e\u52b9\u679c\u63a8\u5b9a\u5024\u306b\u306f\u78ba\u4fe1\u304c\u304a\u3051\u306a\u3044\u3068\u5224\u65ad\u3059\u308b\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n<\/td>\n<\/tr>\n<\/table>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

\u4ee5\u4e0b\u306f\u5ca9\u5d0e\u92fc\u5148\u751f\uff08\u6771\u5317\u5927\u5b66\u5927\u5b66\u9662\u533b\u5b66\u7cfb\u7814\u7a76\u79d1\u30fb\u533b\u5b66\u90e8\uff09\u306eFB\u306b\u304a\u3051\u308b\u8a18\u4e8b\uff082015\/9\/9\uff09\u3067\u3059\u3002\u3053\u306e\u5185\u5bb9\u306b\u306f\u3001GRADE\u306b\u95a2\u3059\u308b\u57fa\u672c\u7684\u306a\u8aa4\u89e3\u3084\u3001GRADE\u9069\u7528\u524d\u306e\u5224\u65ad\u306e\u8aa4\u89e3\u304c\u3042\u308a\u307e\u3059\u3002\u8ee2\u8f09\u53ef\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u306e\u3067\u3001\u305d\u306e\u51fa\u5178 […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[5],"tags":[],"_links":{"self":[{"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/posts\/2395"}],"collection":[{"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2395"}],"version-history":[{"count":34,"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/posts\/2395\/revisions"}],"predecessor-version":[{"id":2496,"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/posts\/2395\/revisions\/2496"}],"wp:attachment":[{"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2395"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2395"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2395"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}