{"id":267,"date":"2013-03-16T11:18:20","date_gmt":"2013-03-16T02:18:20","guid":{"rendered":"http:\/\/aihara.la.coocan.jp\/blog\/?p=267"},"modified":"2014-04-16T15:30:58","modified_gmt":"2014-04-16T06:30:58","slug":"rct%e3%81%8c1%e4%bb%b6%e3%81%97%e3%81%8b%e3%81%aa%e3%81%84%e5%a0%b4%e5%90%88%e3%81%ae%e3%82%a8%e3%83%93%e3%83%87%e3%83%b3%e3%82%b9%e3%81%ae%e8%b3%aa%e3%81%ae%e8%a9%95%e4%be%a1","status":"publish","type":"post","link":"http:\/\/aihara.la.coocan.jp\/?p=267","title":{"rendered":"RCT\u304c1\u4ef6\u3057\u304b\u306a\u3044\u5834\u5408\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u306e\u8cea\u306e\u8a55\u4fa1"},"content":{"rendered":"<div>\n<p>GRADE\u3092\u4f7f\u3063\u3066\u3001\u7dcf\u4f53\u30a8\u30d3\u30c7\u30f3\u30b9\uff08body of evidence\uff09\u306e\u8cea\u3092\u8a55\u4fa1\u3059\u308b\u969b\u306b\u306f\u3001\u300c\u30a8\u30d3\u30c7\u30f3\u30b9\u306e\u8cea\u3001\u3059\u306a\u308f\u3061\u52b9\u679c\u63a8\u5b9a\u5024\u304c\u6b63\u3057\u3044\u3068\u3044\u3046\u78ba\u4fe1\u306e\u7a0b\u5ea6\u306f\u3001\u9023\u7d9a\u7684\u306a\u3082\u306e\u3067\u3042\u308b\u300d\u3068\u3044\u3046\u8a8d\u8b58\u304c\u5fc5\u8981\u3067\u3059\u3002<br \/>\n\u8907\u6570\u306eRCT\u304b\u3089\u306e\u7dcf\u4f53\u30a8\u30d3\u30c7\u30f3\u30b9(4)\u304c\u3001\u30d0\u30a4\u30a2\u30b9\u306e\u30ea\u30b9\u30af(-1)\u3001\u4e0d\u7cbe\u78ba\u3055(-1)\u3001\u975e\u4e00\u8cab\u6027(-1)\u3001\u975e\u76f4\u63a5\u6027(0)\u3001\u51fa\u7248\u30d0\u30a4\u30a2\u30b9(0)\u3001\u306a\u306e\u3067\u30014-3=1\u3001&#8221;very low&#8221;\u3068\u3044\u3046\u5224\u65ad\u306f\u3088\u304f\u306a\u3044\u3068\u3044\u3046\u610f\u5473\u3067\u3001\u30d0\u30a4\u30a2\u30b9\u306e\u30ea\u30b9\u30af\u3068\u4e0d\u7cbe\u78ba\u3055\u3092\u5408\u308f\u305b\u3066(-1)\u306a\u3069\u3068\u3044\u3046\u5224\u65ad\u3082\u3042\u308a\u3046\u308b\u3068\u3044\u3046\u8003\u3048\u3067\u3059\u3002<\/p>\n<p><\/p>\n<p><b>\u25a0Quality of evidence: confidence in estimates as a continuum<\/b><br \/>\n\u4e0b\u56f3\u306f\u3001GRADE\u3092\u4e0b\u3052\u308b\uff15\u8981\u56e0\u306e\u3046\u3061\u3001risk of bias, imprecision, indirectness\u3092\u4f7f\u3063\u3066\u3001\u30a8\u30d3\u30c7\u30f3\u30b9\u306e\u8cea\u306e\u9023\u7d9a\u6027\u3092\u8aac\u660e\u3057\u305f\u3082\u306e\u3067\u3059\u3002<\/p>\n<p><a href=\"http:\/\/aihara.la.coocan.jp\/blog_0316.php\" onclick=\"window.open('http:\/\/aihara.la.coocan.jp\/blog_0316.php','popup','width=989,height=567,scrollbars=no,resizable=no,toolbar=no,directories=no,location=no,menubar=no,status=no,left=0,top=0'); return false\"><img decoding=\"async\" loading=\"lazy\" src=\"http:\/\/aihara.la.coocan.jp\/blog_0316-thumb.jpg\" width=\"500\" height=\"286\" alt=\"qoe\" \/><\/a><br \/>\n<br clear=\"all\" \/><\/p>\n<p><b>\u25a0<\/b><span style=\"color:#FF0000;\"><b>RCT\u304c1\u4ef6\u3057\u304b\u306a\u3044\u5834\u5408\u306f\u3069\u3046\u3059\u308b\u304b\uff1f<\/b><\/span><br \/>\nWhat to do when there is only one RCT<br \/>\n<i>Many people are uncomfortable designating a single RCT as high-quality evidence. Given the many instances in which the first positive report has not held up under subsequent investigation, this discomfort is warranted. On the other hand, automatically rating down quality when there is a single study is not appropriate. A single, very large, rigorously planned and conducted multicentre RCT may provide high-quality evidence. GRADE suggests especially careful scrutiny of all relevant issues (risk of bias, precision, directness, and publication bias) when only a single RCT addresses a particular question.<\/i> (GRADE JCE-4\u3088\u308a)<\/p>\n<p><\/p>\n<p><span style=\"color:#FF0000;\"><br \/>\n1\u4ef6\u306eRCT\u3092\u8cea\u306e\u9ad8\u3044\u30a8\u30d3\u30c7\u30f3\u30b9\u3068\u547c\u3076\u3053\u3068\u306b\u306f\u62b5\u6297\u306e\u3042\u308b\u4eba\u304c\u591a\u3044\u3002\u6700\u521d\u306e\u80af\u5b9a\u7684\u306a\u5831\u544a\u304c\u305d\u308c\u4ee5\u964d\u306e\u7814\u7a76\u306b\u3088\u308a\u8986\u3055\u308c\u308b\u3053\u3068\u306f\u3088\u304f\u3042\u308b\u3053\u3068\u304b\u3089\u3001\u62b5\u6297\u304c\u3042\u308b\u306e\u3082\u7121\u7406\u306f\u306a\u3044\u3002\u4e00\u65b9\u3001\u7814\u7a76\u304c1\u4ef6\u3057\u304b\u306a\u3051\u308c\u3070\u6a5f\u68b0\u7684\u306b\u8a55\u4fa1\u3092\u4e0b\u3052\u3066\u3057\u307e\u3046\u306e\u306f\u4e0d\u9069\u5207\u3067\u3042\u308b\u30021\u4ef6\u306e\u975e\u5e38\u306b\u5927\u898f\u6a21\u3067\u53b3\u683c\u306b\u8a08\u753b\u3001\u5b9f\u884c\u3055\u308c\u305f\u591a\u65bd\u8a2d\u5171\u540cRCT\u306a\u3089\u3070\u8cea\u306e\u9ad8\u3044\u30a8\u30d3\u30c7\u30f3\u30b9\u304c\u5f97\u3089\u308c\u308b\u304b\u3082\u3057\u308c\u306a\u3044\u3002GRADE\u306f\u3001\u3042\u308b\u7279\u5b9a\u306e\u7591\u554f\u3092\u53d6\u308a\u4e0a\u3052\u305fRCT\u304c1\u4ef6\u3057\u304b\u306a\u3044\u5834\u5408\u306b\u306f\u3001\u5168\u3066\u306e\u95a2\u9023\u3059\u308b\u554f\u984c\uff08\u30d0\u30a4\u30a2\u30b9\u306e\u30ea\u30b9\u30af\u3001\u7cbe\u78ba\u3055\u3001\u76f4\u63a5\u6027\u3001\u51fa\u7248\u30d0\u30a4\u30a2\u30b9\uff09\u3092\u614e\u91cd\u306b\u541f\u5473\u3059\u308b\u3088\u3046\u63d0\u8a00\u3059\u308b\u3002<\/span><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>GRADE\u3092\u4f7f\u3063\u3066\u3001\u7dcf\u4f53\u30a8\u30d3\u30c7\u30f3\u30b9\uff08body of evidence\uff09\u306e\u8cea\u3092\u8a55\u4fa1\u3059\u308b\u969b\u306b\u306f\u3001\u300c\u30a8\u30d3\u30c7\u30f3\u30b9\u306e\u8cea\u3001\u3059\u306a\u308f\u3061\u52b9\u679c\u63a8\u5b9a\u5024\u304c\u6b63\u3057\u3044\u3068\u3044\u3046\u78ba\u4fe1\u306e\u7a0b\u5ea6\u306f\u3001\u9023\u7d9a\u7684\u306a\u3082\u306e\u3067\u3042\u308b\u300d\u3068\u3044\u3046\u8a8d\u8b58\u304c\u5fc5\u8981\u3067\u3059\u3002 \u8907\u6570\u306eRCT\u304b\u3089\u306e\u7dcf [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[368],"tags":[369],"_links":{"self":[{"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/posts\/267"}],"collection":[{"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=267"}],"version-history":[{"count":1,"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/posts\/267\/revisions"}],"predecessor-version":[{"id":415,"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/posts\/267\/revisions\/415"}],"wp:attachment":[{"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=267"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=267"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=267"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}