{"id":286,"date":"2013-07-06T09:36:48","date_gmt":"2013-07-06T00:36:48","guid":{"rendered":"http:\/\/aihara.la.coocan.jp\/blog\/?p=286"},"modified":"2015-10-20T16:46:05","modified_gmt":"2015-10-20T07:46:05","slug":"%e5%9b%a0%e6%9e%9c%e9%96%a2%e4%bf%82%e3%81%ae%e3%81%9f%e3%82%81%e3%81%aegrade%e3%82%a2%e3%83%97%e3%83%ad%e3%83%bc%e3%83%81%e3%81%a8bradford-hill-%e5%9f%ba%e6%ba%96","status":"publish","type":"post","link":"http:\/\/aihara.la.coocan.jp\/?p=286","title":{"rendered":"\u56e0\u679c\u95a2\u4fc2\u306e\u305f\u3081\u306eGRADE\u30a2\u30d7\u30ed\u30fc\u30c1\u3068Bradford Hill \u57fa\u6e96"},"content":{"rendered":"
\n\"bradford_grade.jpg\"<\/a>
\n
<\/p>\n

RCT\u3084\u89b3\u5bdf\u7814\u7a76\uff08\u30b3\u30db\u30fc\u30c8\u7814\u7a76\u3001\u75c7\u4f8b\u5bfe\u7167\u7814\u7a76\uff09\u306b\u3088\u3063\u3066\u66dd\u9732\u3068\u30a2\u30a6\u30c8\u30ab\u30e0\u3068\u306e\u95a2\u9023\uff08association\uff09\u304c\u3042\u308b\u3053\u3068\u304c\u78ba\u304b\u3081\u3089\u308c\u305f\u3089\u3070\u3001\u6b21\u306e\u554f\u984c\u306f\u3001\u89b3\u5bdf\u3055\u308c\u305f\u95a2\u9023\u304c\u306f\u305f\u3057\u3066\u56e0\u679c\u95a2\u4fc2\uff08causal relationship\uff09\u304c\u3069\u3046\u304b\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002\u56e0\u679c\u95a2\u4fc2\u306e\u63a8\u5b9a\u306b\u304a\u3044\u3066\u306fBradford Hill\u304c\u63d0\u6848\u3057\u305f9\u9805\u76ee\u304c\u6709\u540d\u3067\u3059\u304c\u3001\u89b3\u5bdf\u7814\u7a76\u304b\u3089\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u306e\u8cea\u3092\u8a55\u4fa1\u3059\u308b\u969b\u306eGRADE\u30a2\u30d7\u30ed\u30fc\u30c1\u306fBradford Hill\u57fa\u6e96\u306e\u307b\u3068\u3093\u3069\u3092\u9069\u5207\u306b\u7d44\u307f\u8fbc\u3093\u3067\u3044\u308b\u3053\u3068\u304c\u767a\u8868\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

<\/p>\n

\u56e0\u679c\u95a2\u4fc2\u306e\u305f\u3081\u306eGRADE\u30a2\u30d7\u30ed\u30fc\u30c1\u3068Bradford Hill\u57fa\u6e96<\/b><\/span><\/a>\uff08grade_vs_bradford_hill_ma.pdf\uff09<\/p>\n

<\/p>\n\n\n\n\n\n\n\n\n\n\n\n
Bradford Hill\u57fa\u6e96<\/b><\/td>\nGRADE\u306b\u304a\u3051\u308b\u8003\u616e<\/b><\/td>\n<\/tr>\n
\u57fa\u6e961\uff1a\u95a2\u9023\u306e\u5f37\u3055\uff08Strength of the association\uff09<\/td>\nStrength of association and imprecision in effect estimate<\/td>\n<\/tr>\n
\u57fa\u6e962\uff1a\u4e00\u8cab\u6027\uff08Consistency\uff09<\/td>\nConsistency across studies, ie, across different situations (different researchers)<\/td>\n<\/tr>\n
\u57fa\u6e963\uff1a\u6642\u9593\u7684\u95a2\u4fc2\uff08Temporality\uff09<\/td>\nStudy design, specific study limitations; RCTs fulfil this criterion better than observational studies, properly designed and conducted observational studies<\/td>\n<\/tr>\n
\u57fa\u6e964\uff1a\u751f\u7269\u5b66\u7684\u7528\u91cf\u53cd\u5fdc\u52fe\u914d\uff08Biological gradient\uff09<\/td>\nDose-response gradient<\/td>\n<\/tr>\n
\u57fa\u6e965\uff1a\u7279\u7570\u6027\uff08Specificity\uff09<\/td>\nIndirectness<\/td>\n<\/tr>\n
\u57fa\u6e966\uff1a\u751f\u7269\u5b66\u7684\u59a5\u5f53\u6027\uff08Biological plausibility\uff09<\/td>\nIndirectness<\/td>\n<\/tr>\n
\u57fa\u6e967\uff1a\u6574\u5408\u6027\uff08Coherence\uff09<\/td>\nIndirectness<\/td>\n<\/tr>\n
\u57fa\u6e968\uff1a\u5b9f\u9a13\uff08Experiment\uff09<\/td>\nStudy design, randomisation, properly designed and conducted observational studies<\/td>\n<\/tr>\n
\u57fa\u6e969\uff1a\u985e\u4f3c\u6027\uff08Analogy\uff09<\/td>\nExisting association for critical outcomes will lead to not downgrading the quality, indirectness<\/td>\n<\/tr>\n<\/table>\n

\u6587\u732e
\n\u25cf Bradford Hill A: The Environment and Disease: Association or Causation? Proc R Soc Med. 1965 May; 58(5): 295\u2013300.
\n\u25cf Schunemann HJ, Hill S, Guyatt G, Akl EA, Ahmed F: The GRADE approach and Bradford Hill’s criteria for causation. J Epidemiol Community Health 2011; 65:392-395. doi:10.1136\/jech.2010<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

RCT\u3084\u89b3\u5bdf\u7814\u7a76\uff08\u30b3\u30db\u30fc\u30c8\u7814\u7a76\u3001\u75c7\u4f8b\u5bfe\u7167\u7814\u7a76\uff09\u306b\u3088\u3063\u3066\u66dd\u9732\u3068\u30a2\u30a6\u30c8\u30ab\u30e0\u3068\u306e\u95a2\u9023\uff08association\uff09\u304c\u3042\u308b\u3053\u3068\u304c\u78ba\u304b\u3081\u3089\u308c\u305f\u3089\u3070\u3001\u6b21\u306e\u554f\u984c\u306f\u3001\u89b3\u5bdf\u3055\u308c\u305f\u95a2\u9023\u304c\u306f\u305f\u3057\u3066\u56e0\u679c\u95a2\u4fc2\uff08causal relationship\uff09 […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[395,5],"tags":[396,397],"_links":{"self":[{"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/posts\/286"}],"collection":[{"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=286"}],"version-history":[{"count":4,"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/posts\/286\/revisions"}],"predecessor-version":[{"id":2867,"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/posts\/286\/revisions\/2867"}],"wp:attachment":[{"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=286"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=286"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=286"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}