{"id":29,"date":"2007-10-25T10:11:20","date_gmt":"2007-10-25T01:11:20","guid":{"rendered":"http:\/\/aihara.la.coocan.jp\/blog\/?p=29"},"modified":"2014-04-16T15:36:25","modified_gmt":"2014-04-16T06:36:25","slug":"pioglitazone%e3%81%a8%e5%bf%83%e8%a1%80%e7%ae%a1%e3%82%a4%e3%83%99%e3%83%b3%e3%83%88%e5%a2%97%e5%8a%a0","status":"publish","type":"post","link":"http:\/\/aihara.la.coocan.jp\/?p=29","title":{"rendered":"pioglitazone\u3068\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u5897\u52a0"},"content":{"rendered":"<div>\n<p><b>\u30a2\u30af\u30c8\u30b9\u306b\u3064\u3044\u3066\uff1a<\/b><br \/>\n\u8fd1\u96a3\u3067\u3082\u975e\u5e38\u306b\u591a\u7528\u3055\u308c\u3066\u3044\u308b\u85ac\u5264\u3067\u3059\u304c\u3001\u3044\u304f\u3089\u3053\u3061\u3089\u3067\u8aac\u660e\u3057\u3066\u3082\u85ac\u5264\u306e\u6ce8\u610f\u52e7\u544a\u90e8\u5206\u304c\u4f1d\u308f\u3063\u3066\u3044\u307e\u305b\u3093\u3002NEJM(6\/14)\u3084FDA\u52e7\u544a\u306a\u3069\u306f\u307b\u3068\u3093\u3069\u7121\u8996\u3055\u308c\u3001\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u7d50\u679c\u306a\u3069\u3082\u3042\u307e\u308a\u3088\u304f\u7406\u89e3\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002\u3080\u3057\u308d\u3001\u7a4d\u6975\u7684\u306b\u3001\u5fc3\u7b4b\u6897\u585e\u30b9\u30c6\u30f3\u30c8\u5f8c\u306e\u518d\u72ed\u7a84\u4e88\u9632\u306a\u3069\u3068\u3044\u3046\u60c5\u5831\u304c\u666e\u53ca\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\n<a href=\"http:\/\/aihara.la.coocan.jp\/edema-sex2.php\" onclick=\"window.open('http:\/\/aihara.la.coocan.jp\/edema-sex2.php','popup','width=434,height=304,scrollbars=no,resizable=no,toolbar=no,directories=no,location=no,menubar=no,status=no,left=0,top=0'); return false\" onkeypress=\"window.open('http:\/\/aihara.la.coocan.jp\/edema-sex2.php','popup','width=434,height=304,scrollbars=no,resizable=no,toolbar=no,directories=no,location=no,menubar=no,status=no,left=0,top=0'); return false\"><img decoding=\"async\" loading=\"lazy\" src=\"http:\/\/aihara.la.coocan.jp\/edema-sex-thumb.gif\" width=\"150\" height=\"105\" alt=\"edema\" \/><\/a><\/p>\n<p>\u5b9f\u969b\u3001\u88fd\u85ac\u30e1\u30fc\u30ab\u30fcHP\u3067\u3082\u6d6e\u816b\u306b\u3064\u3044\u3066\u56f3\u306e\u3088\u3046\u306b\u516c\u8868\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u3042\u307e\u308a\u533b\u7642\u306e\u6700\u524d\u7dda\u3068\u3057\u3066\u306e\u4e00\u822c\u81e8\u5e8a\u533b\u306b\u306f\u4f1d\u308f\u3063\u3066\u3044\u306a\u3044\u3088\u3046\u306b\u601d\u3044\u307e\u3059\u3002<br \/>\n<b>\u3044\u308d\u3044\u308d\u306a\u300c\u5fc3\u4e0d\u5168\u767a\u75c7\u306e\u304a\u305d\u308c\u306e\u3042\u308b\u5fc3\u7b4b\u6897\u585e\u3001\u72ed\u5fc3\u75c7\u3001\u5fc3\u7b4b\u75c7\u3001\u9ad8\u8840\u5727\u6027\u5fc3\u75be\u60a3\u7b49\u306e\u5fc3\u75be\u60a3\u306e\u3042\u308b\u60a3\u8005[\u5faa\u74b0\u8840\u6f3f\u91cf\u306e\u5897\u52a0\u306b\u3088\u308a\u5fc3\u4e0d\u5168\u3092\u767a\u75c7\u3055\u305b\u308b\u304a\u305d\u308c\u304c\u3042\u308b\u3002\u300d\uff08\uff62\u91cd\u8981\u306a\u57fa\u672c\u7684\u6ce8\u610f\uff63\u3001\uff62\u91cd\u5927\u306a\u526f\u4f5c\u7528\uff63\u306e\u9805\u53c2\u7167\uff09<\/b><br \/>\n\u6d6e\u816b\u767a\u73fe\u983b\u5ea6\u306b\u306f\u6027\u5dee\u304c\u3042\u308a\u3001\u7537\u6027vs \u5973\u6027\u3067\u3001OR=0.65\uff080.47-0.9\uff09\u3067\u3059\uff08\u76f8\u539f\uff09\u3002<br \/>\n\u3053\u306e\u70b9\u306b\u3064\u3044\u3066\u306f\u3001<a href=\"http:\/\/www.yakugai.gr.jp\/attention\/attention.php?id=163\" target=\"_blank\">\u85ac\u5bb3\u30aa\u30f3\u30d6\u30ba\u30d1\u30fc\u30b9\u30f3\u4f1a\u8b70<\/a>\u3067\u3082\u540c\u3058\u3088\u3046\u306b\u7d39\u4ecb\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><\/p>\n<p>\u5f53\u9662\u62c5\u5f53MR\u304b\u3089\u201d\u30a2\u30af\u30c8\u30b9\u6709\u52b9\u3068\u3044\u3046\u56fd\u5185\u6587\u732e\u201d\u3092\u5165\u624b\u3067\u304d\u305f\u306e\u304c\u4ee5\u4e0b\u306e1\u4ef6\u306e\u307f\u3067\u3057\u305f\u3002<br \/>\n\u25a0Yokoyama J, et atl: Efficacy and safety of low-dose pioglitazone after primary coronary angioplasty with the use of bare metal stent in patients with acute myocardial infarction and with type 2 diabetes mellitus or impaired glucose tolerance. Heart Vessels. 2007 May;22(3):146-51. Epub 2007 May 21. PMID: 17533517<\/p>\n<p><\/p>\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<br \/>\n\u3053\u306e\u7814\u7a76\u306e\u554f\u984c\u70b9\uff08by \u76f8\u539f\uff09\uff1a<br \/>\n\u25a0\u75c7\u4f8b\u5bfe\u7167\u7814\u7a76\u3067\u30012\u7fa4\u3067\u8a2d\u5b9a\u3057\u3066\u3044\u308b\u306e\u306f\u300156\u4f8b\u3000vs\u300037\u4f8b\u3068\u3044\u3046\u3001\u901a\u5e38\u306e\u30b5\u30f3\u30d7\u30eb\u8a2d\u5b9a\u3068\u306f\u3000\u9006\u306e\u30d1\u30bf\u30fc\u30f3\u3092\u4f7f\u3063\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u3069\u306e\u3088\u3046\u306b\u3057\u3066\u5fc5\u8981\u30b5\u30f3\u30d7\u30eb\u6570\u3092\u8a2d\u5b9a\u3057\u305f\u306e\u304b\u3082\u8a18\u8f09\u3042\u308a\u307e\u305b\u3093\u3002<br \/>\n\u25a0\u524d\u3048\u5411\u304d\u7814\u7a76\u3068\u3057\u3066\u5b9f\u65bd\u3059\u308b\u3068\u3057\u3066\u3082\u3001\u03b10.05\u3001\u691c\u51fa\u529b80%\u3068\u3057\u3066\u8a08\u7b97\u3059\u308b\u3068\u5404100\u4f8b\u304c\u5fc5\u8981\u3067\u3059\u3002<br \/>\n\u25a0\u8ad6\u6587\u4e2d\u3067\u3001\u305f\u3073\u305f\u3073\u8a18\u8f09\u306e\u3042\u308b\u52d5\u8108\u5185\u306e\u72ed\u7a84\u7a0b\u5ea6\u306e\u8868\u793a\u304c\u3001\u3088\u304f\u3042\u308b\u5e73\u5747\u00b1SD\u3067\u3001\u4f8b\u3048\u30700.26\u00b10.46\u3068\u3044\u3046\u3001mean&gt;2SD\u3068\u3044\u3046\u6761\u4ef6\u3092\u6e80\u305f\u3057\u3066\u3044\u307e\u305b\u3093\u3002<br \/>\n\u25a0baseline risk\u306e\u6bd4\u8f03\u306710\u6570\u500b\u4ee5\u4e0a\u3092\u6bd4\u8f03\u3057\u3066\u6709\u610f\u5dee\uff08p&lt;0.05\uff09\u304c\u3042\u3063\u305f\u3068\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\n\u25a0\u30a2\u30af\u30c8\u30b9\u3092\u8ffd\u52a0\u6cbb\u7642\u3057\u306a\u3044\u3068\u3001\u30b9\u30c6\u30f3\u30c8\u8a2d\u7f6e\u5f8c\u306e\u534a\u5e74\u5f8c\u306e\u6210\u7e3e\u3067\u3001\u7d04\u534a\u5206\uff0850%\uff09\u304c\u3000\u518d\u72ed\u7a84\u3092\u304a\u3053\u3057\u3066\u308b\u3068\u3044\u3046\u767a\u8868\u3067\u3001\u4ed6\u306e\u770c\u5916\u65bd\u8a2d\u3067\u306f\u30b9\u30c6\u30f3\u30c8\u5f8c\u306e\u518d\u72ed\u7a84\u306e\u7387\u306f10-20\uff05\u3067\u3059\u3002<br \/>\n\u25a0\u5b9f\u969b\u3001\u5f53\u9662\u306e\u60a3\u8005\u30821\u5e74\u306b3~4\u56de\u306e\u518d\u72ed\u7a84\u306b\u3088\u308b\u5165\u9662\u304c\u3042\u308a\u3001\u3053\u308c\u304c\u304d\u3063\u304b\u3051\u3067\u4e3b\u6cbb\u533b\u306b\u9023\u7d61\u3057\u305f\u7406\u7531\u3067\u3059\u3002<br \/>\n===============================================================<\/p>\n<p><\/p>\n<p><a href=\"http:\/\/aihara.la.coocan.jp\/Rosiglitazone%20for%20DM.php\" onclick=\"window.open('http:\/\/aihara.la.coocan.jp\/Rosiglitazone%20for%20DM.php','popup','width=693,height=341,scrollbars=no,resizable=no,toolbar=no,directories=no,location=no,menubar=no,status=no,left=0,top=0'); return false\"><img decoding=\"async\" loading=\"lazy\" src=\"http:\/\/aihara.la.coocan.jp\/Rosiglitazone%20for%20DM-thumb.jpg\" width=\"200\" height=\"98\" alt=\"cochrane\" \/><\/a><br \/>\n\u30b3\u30af\u30e9\u30f3\u30fb\u30e9\u30a4\u30d6\u30e9\u30ea\u30fc\uff082007,issue 3)\u3067\u306f<br \/>\nB Richter, E Bandeira-Echtler, K Bergerhoff, C Clar, SH Ebrahim. Rosiglitazone for type 2 diabetes mellitus. Cochrane Database of Systematic Reviews 2007, Issue 3. Art. No.: CD006063. DOI: 10.1002\/14651858.CD006063.pub2.<\/p>\n<p><\/p>\n<p><b>[\u7d50\u679c]\uff1a<\/b><br \/>\nMetabolic control measured by glycosylated haemoglobin A1c (HbA1c) as a surrogate endpoint did not demonstrate clinically relevant differences to other oral antidiabetic drugs. Occurrence of oedema was significantly raised (OR 2.27, 95% confidence interval (CI) 1.83 to 2.81). The single large RCT (ADOPT &#8211; A Diabetes Outcomes Progression Trial) indicated increased cardiovascular risk. New data on raised fracture rates in women reveal extensive action of rosiglitazone in various body tissues.<br \/>\n=====================================================================<\/p>\n<p><\/p>\n<p>\u306a\u305c\u3001\u3044\u304f\u3064\u304b\u3082\u306e\u6b20\u70b9\u304c\u3042\u308b\u56fd\u5185\u8ad6\u6587\u306e\u6210\u7e3e\u304c\u85ac\u5264\u6cbb\u7642\u306e\u63a8\u5968\u306b\u3064\u306a\u304c\u308b\u306e\u304b\u7406\u89e3\u304c\u3067\u304d\u307e\u305b\u3093\u3002<br \/>\u4e0a\u8a18\u85ac\u5bb3\u30aa\u30f3\u30d6\u30ba\u30d1\u30fc\u30b9\u30f3\u4f1a\u8b70\u30b5\u30a4\u30c8\u304b\u3089\uff1a<br \/>\n<b>\u7cd6\u5c3f\u75c5\u6cbb\u7642\u85ac(PPAR-\u03b3\u4f5c\u52d5\u85ac)\u30a2\u30af\u30c8\u30b9\u306b\u3064\u3044\u3066\u3001\u65e5\u672c\u306b\u304a\u3044\u3066\u306f2000\u5e744\u6708\u304a\u3088\u307310\u6708\u306e\u65e9\u3044\u6642\u671f\u306b\u3001\u30a2\u30af\u30c8\u30b9\u306f\u81e8\u5e8a\u7528\u91cf\u3067\u5fc3\u6bd2\u6027\uff08\u5fc3\u80a5\u5927\u306a\u3069\uff09\u3068\u9aa8\u6bd2\u6027\uff08\u9aa8\u91cf\u6e1b\u5c11\uff09\u3001\u767a\u304c\u3093\u6027\uff08\u8180\u80f1\u304c\u3093\uff09\u304c\u8a8d\u3081\u3089\u308c\u3066\u3044\u308b\u305f\u3081\u3001\u4f7f\u7528\u3092\u4e2d\u6b62\u3001\u88fd\u9020\u627f\u8a8d\u3092\u53d6\u308a\u6d88\u3059\u3079\u304d\u3067\u3042\u308b\u3068\u3001TIP(\u6b63\u3057\u3044\u6cbb\u7642\u3068\u85ac\u306e\u60c5\u5831)\u8a8c\u3067\u6307\u6458\u3055\u308c\u3066\u3044\u308b(\u203b9\u3001\u203b10)\u3002\u5f53\u4f1a\u8b70\u3067\u306f\u3001\u30a2\u30af\u30c8\u30b9\u306e\u5fc3\u6bd2\u6027\u306a\u3069\u3092\u91cd\u5927\u306a\u554f\u984c\u3068\u3057\u3066\u3068\u3089\u3048\u30012000\u5e7410\u6708\u306b\u3001\u85ac\u4e8b\u6cd569\u6761\u306e3\u306b\u57fa\u3065\u304d\u8ca9\u58f2\u4e2d\u6b62\u3068\u56de\u53ce\u306e\u7dca\u6025\u547d\u4ee4\u767a\u52d5\u3092\u6c42\u3081\u308b\u8981\u671b\u66f8\u3092\u63d0\u51fa\u3057\u3066\u3044\u308b\u3002<\/b><\/p>\n<p><\/p>\n<p>\u2605\u7dcf\u5408\u7684\u306b\u5224\u65ad\u3059\u308b\u3068\u3001\u65e5\u672c\u4eba\u3067\u306e\u30c7\u30fc\u30bf\u304c\u5c11\u306a\u3044\u3082\u306e\u306e\u3001pioglitazone\u306f\u591a\u304f\u306e\u60a3\u8005\u3067\u63a8\u5968\u3067\u304d\u306a\u3044\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u30a2\u30af\u30c8\u30b9\u306b\u3064\u3044\u3066\uff1a \u8fd1\u96a3\u3067\u3082\u975e\u5e38\u306b\u591a\u7528\u3055\u308c\u3066\u3044\u308b\u85ac\u5264\u3067\u3059\u304c\u3001\u3044\u304f\u3089\u3053\u3061\u3089\u3067\u8aac\u660e\u3057\u3066\u3082\u85ac\u5264\u306e\u6ce8\u610f\u52e7\u544a\u90e8\u5206\u304c\u4f1d\u308f\u3063\u3066\u3044\u307e\u305b\u3093\u3002NEJM(6\/14)\u3084FDA\u52e7\u544a\u306a\u3069\u306f\u307b\u3068\u3093\u3069\u7121\u8996\u3055\u308c\u3001\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u7d50\u679c\u306a\u3069\u3082\u3042\u307e\u308a\u3088\u304f\u7406\u89e3\u3055\u308c [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[13],"tags":[36,20],"_links":{"self":[{"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/posts\/29"}],"collection":[{"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=29"}],"version-history":[{"count":1,"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/posts\/29\/revisions"}],"predecessor-version":[{"id":653,"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/posts\/29\/revisions\/653"}],"wp:attachment":[{"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=29"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=29"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=29"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}