{"id":3920,"date":"2016-05-02T14:41:31","date_gmt":"2016-05-02T05:41:31","guid":{"rendered":"http:\/\/aihara.la.coocan.jp\/?p=3920"},"modified":"2016-05-02T14:51:05","modified_gmt":"2016-05-02T05:51:05","slug":"%e7%b4%af%e7%a9%8d%e3%83%a1%e3%82%bf%e3%82%a2%e3%83%8a%e3%83%aa%e3%82%b7%e3%82%b9%e3%81%aetrial-sequential-analysis%ef%bc%88%e9%80%90%e6%ac%a1%e8%a7%a3%e6%9e%90%ef%bc%89","status":"publish","type":"post","link":"http:\/\/aihara.la.coocan.jp\/?p=3920","title":{"rendered":"\u7d2f\u7a4d\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u306eTrial Sequential Analysis\uff08\u9010\u6b21\u89e3\u6790\uff09"},"content":{"rendered":"

\u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a13\uff08RCT\uff09\u306f\u3001\u6cbb\u7642\u52b9\u679c\u306b\u95a2\u3059\u308b\u56e0\u679c\u95a2\u4fc2\u63a8\u6e2c\u306e\u30b4\u30fc\u30eb\u30c9\u30b9\u30bf\u30f3\u30c0\u30fc\u30c9\u3067\u3042\u308a\u3001RCT\u306e\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u306f\u4e88\u6e2c\u3055\u308c\u308b\u6cbb\u7642\u52b9\u679c\u306e\u691c\u51fa\u529b\u3068\u6b63\u78ba\u6027\u3092\u9ad8\u3081\u308b\u3082\u306e\u3067\u3059\u3002\u3057\u304b\u3057\u3001\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u306f\u507d\u967d\u6027\u7d50\u679c\u3092\u3082\u305f\u3089\u3059\u30ea\u30b9\u30af\u304c\u3042\u308a\uff08\u6cbb\u7642\u52b9\u679c\u304c\u306a\u3044\u306e\u306b\u6cbb\u7642\u52b9\u679c\u304c\u3042\u308b\u3088\u3046\u306a\u5831\u544a\uff09\u3001\u7279\u306b\u5c0f\u898f\u6a21RCT\u304c\u904e\u5270\u8a55\u4fa1\u306b\u3064\u306a\u304c\u308a\u3084\u3059\u3044\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u901a\u5e38\u306e\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u306b\u304a\u3051\u308b\u30e9\u30f3\u30c0\u30e0\u8aa4\u5dee\u3092\u89e3\u6d88\u3057\u3001\u8aa4\u3063\u305f\u7d50\u8ad6\u306b\u5bfe\u51e6\u3059\u3079\u304f\u3001\u4ee5\u4e0b\u306eTrial Sequential Analysis\uff08\u9010\u6b21\u89e3\u6790\uff09<\/strong>\u304c\u958b\u767a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n

<\/p>\n

\u30fbPogue and Yusuf(1997,1998)\u304c\u3001\u7d2f\u7a4d\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u306b\u304a\u3051\u308bLan\u2013DeMets trial sequential monitoring boundaries\u306e\u4f5c\u6210\u6cd5\u3092\u63d0\u5531\u3002<\/p>\n

\u30fbWetterslev (2008)\u304c\u3001\u7570\u8cea\u6027\u3092\u8abf\u6574\u3057\u305f\u65b9\u6cd5\u3068\u3057\u3066\u3001Trial Sequential Analysis\uff08TSA\uff09\u3068\u540d\u4ed8\u3051\u305f\u624b\u6cd5\u3092\u767a\u8868\u3002
\nTrial sequential analysis reveals insufficient information size and potentially false positive results in many meta-analyses. Brok J, et al. JCE 2008; 61: 763-9<\/a><\/p>\n

TSA\u306f\u3001RCT\u3092\u5e74\u4ee3\u9806\u306b\u4e26\u3079\u3066\u3001\u53e4\u3044\u65b9\u304b\u3089\u9806\u756a\u306b\u7d2f\u7a4d\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u30c7\u30fc\u30bf\u3068\u3057\u3066\u6709\u610f\u5dee\u691c\u5b9a\u3092\u884c\u3046\u65b9\u6cd5\u3067\u3059\u3002
\n\u89e3\u6790\u306e\u5b9f\u969b\u3068\u3057\u3066\u306f\u3001\u4e8b\u524d\u306b\u8a2d\u5b9a\u3057\u305f\u3001\u81e8\u5e8a\u7684\u306b\u610f\u7fa9\u306e\u3042\u308b\u3068\u3059\u308b\u52b9\u679c\u63a8\u5b9a\u5024\u3001\u03b1\/\u03b2\u30a8\u30e9\u30fc\u3001\u304b\u3089\u306e\u6700\u9069\u60c5\u5831\u91cf\uff08OIS\uff09\u3092\u3001\u5b9f\u969b\u306e\u7d2f\u7a4d\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u306e\u7d71\u5408\u63a8\u5b9a\u5024\u306eZ\u5024\u3068\u6bd4\u8f03\u3057\u307e\u3059\u3002<\/p>\n

TSA\u306e\u305f\u3081\u306b\u5229\u7528\u3067\u304d\u308b\u30c4\u30fc\u30eb\u304c\u3001STATA\uff08\u30b3\u30de\u30f3\u30c9metacumbounds\uff09<\/strong>\u3068R\uff08\u30d1\u30c3\u30b1\u30fc\u30b8foreign, ldbounds\uff09<\/strong>\u3092\u7d44\u307f\u5408\u308f\u305b\u305f\u3082\u306e\u3067\u3059\u3002
\nMiladinovic B, et al: Trial sequential boundaries for cumulative meta-analyses. STATA journal 2013; 13(1): 577-91<\/a>.
\n
\n 
\n<\/p>\n

\u25a0TSA\u306e\uff14\u30d1\u30bf\u30fc\u30f3<\/strong><\/p>\n

\"TSA\"<\/a>
\n<\/p>\n

TSA\u306b\u3088\u308b\uff14\u3064\u306e\u30d1\u30bf\u30fc\u30f3\u306e\u89e3\u91c8\u304c\u4ee5\u4e0b\u3067\u3059\u3002<\/p>\n

    <\/p>\n
  1. Z\u66f2\u7dda\u306fZ=1.96\u306e\u6a2a\u70b9\u7dda\u3068\u4ea4\u5dee\u3057\u6709\u610f\u306a\u7d50\u679c\u3067\u3042\u308b\u304c\u3001monitoring boundary\uff08\u8d64\u7dda\uff09\u3068\u4ea4\u5dee\u3057\u3066\u3044\u306a\u3044\u305f\u3081\u507d\u308a\u306e\u52b9\u679c\u3067\u3042\u308b\uff08\u507d\u967d\u6027\uff09<\/li>\n
  2. Z\u66f2\u7dda\u306f\u60c5\u5831\u91cf\uff08information size\uff09\u306b\u9054\u3059\u308b\u524d\u306bmonitoring boundary\uff08\u8d64\u7dda\uff09\u3068\u4ea4\u5dee\u3057\u3066\u304a\u308a\u3001\u52b9\u679c\u306b\u78ba\u56fa\u305f\u308b\u30a8\u30d3\u30c7\u30f3\u30b9\u3092\u63d0\u4f9b\u3057\u3066\u3044\u308b\uff08\u771f\u967d\u6027\uff09<\/li>\n
  3. Z\u66f2\u7dda\u306fZ=1.96\u306e\u6a2a\u70b9\u7dda\u3068\u4ea4\u5dee\u3057\u3066\u304a\u3089\u305a\u3001\u30a8\u30d3\u30c7\u30f3\u30b9\u304c\u6b20\u5982\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u3059\u3002\u3059\u306a\u308f\u3061\u3001\u5f53\u8a72\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u306f\u3001\u5fc5\u8981\u60c5\u5831\u91cf\u3088\u308a\u60a3\u8005\u304c\u5c11\u306a\u3044\uff08\u507d\u9670\u6027\uff09<\/li>\n
  4. \u5fc5\u8981\u60c5\u5831\u91cf\u3092\u6e80\u305f\u3057\u3066\u3044\u308b\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u4e8b\u524d\u306b\u8a2d\u5b9a\u3057\u305f\u52b9\u679c\u306f\u306a\u3044\uff08\u771f\u9670\u6027\uff09<\/li>\n<\/ol>\n

    \n 
    \n<\/p>\n

    \u25a0STATA\u3068R\u3092\u7d44\u307f\u5408\u308f\u305b\u305fTSA\u89e3\u6790\u4f8b<\/strong><\/p>\n

    \u30c7\u30fc\u30bf\uff1aexample1,2.xlsx<\/a>\uff08\u4e0a\u8a18\u306eMiladinovic\u8ad6\u6587\u3088\u308a\u62bd\u51fa\u3002sheet1=example1\uff09<\/p>\n

    \"LBHIS\"<\/a><\/p>\n

    \u672cTSA\u306b\u304a\u3044\u3066\u306f\u3001\u500b\u5225\u7814\u7a76\u306erisk of bias\u3092\u8abf\u6574\u3057\u305f\u89e3\u6790\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002
    \nLBHIS: low-bias heterogeneity-adjusted information size
    \n\u4f7f\u7528\u30c4\u30fc\u30eb\uff1aSTATA(version 13), R(version 3.1.3)<\/p>\n

    <\/p>\n

    GRADE\u306e\u67a0\u7d44\u307f\u306b\u304a\u3044\u3066\u306f\u3001TSA\u3092\u4f7f\u3063\u3066\u3001”imprecision”\u306e\u8a55\u4fa1\u306b\u5f79\u7acb\u3066\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3059\u3002<\/p>\n

     
    <\/p>\n","protected":false},"excerpt":{"rendered":"

    \u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a13\uff08RCT\uff09\u306f\u3001\u6cbb\u7642\u52b9\u679c\u306b\u95a2\u3059\u308b\u56e0\u679c\u95a2\u4fc2\u63a8\u6e2c\u306e\u30b4\u30fc\u30eb\u30c9\u30b9\u30bf\u30f3\u30c0\u30fc\u30c9\u3067\u3042\u308a\u3001RCT\u306e\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u306f\u4e88\u6e2c\u3055\u308c\u308b\u6cbb\u7642\u52b9\u679c\u306e\u691c\u51fa\u529b\u3068\u6b63\u78ba\u6027\u3092\u9ad8\u3081\u308b\u3082\u306e\u3067\u3059\u3002\u3057\u304b\u3057\u3001\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u306f\u507d\u967d\u6027\u7d50\u679c\u3092\u3082\u305f\u3089\u3059\u30ea\u30b9\u30af\u304c\u3042 […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[437],"tags":[],"_links":{"self":[{"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/posts\/3920"}],"collection":[{"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3920"}],"version-history":[{"count":30,"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/posts\/3920\/revisions"}],"predecessor-version":[{"id":5275,"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/posts\/3920\/revisions\/5275"}],"wp:attachment":[{"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3920"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3920"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3920"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}