{"id":4790,"date":"2016-08-20T08:41:58","date_gmt":"2016-08-19T23:41:58","guid":{"rendered":"http:\/\/aihara.la.coocan.jp\/?p=4790"},"modified":"2017-09-04T09:56:15","modified_gmt":"2017-09-04T00:56:15","slug":"grade-cpg%e4%bd%9c%e6%88%90%e3%81%ae%e5%9f%ba%e6%9c%ac%e3%83%bc%ef%bc%93%ef%bc%8e%ef%bc%98%ef%bc%9asr%e3%82%a8%e3%83%93%e3%83%87%e3%83%b3%e3%82%b9%e3%81%ae%e7%a2%ba%e5%ae%9f%e6%80%a7-%e2%91%a4","status":"publish","type":"post","link":"http:\/\/aihara.la.coocan.jp\/?p=4790","title":{"rendered":"GRADE CPG\u4f5c\u6210\u306e\u57fa\u672c\u30fc\uff13\uff0e\uff18\uff1a[SR]\u30a8\u30d3\u30c7\u30f3\u30b9\u306e\u78ba\u5b9f\u6027-\u2464\uff1aPublication bias"},"content":{"rendered":"

[GRADE-CPG\u89e3\u8aac\u8cc7\u6599-\u246d]<\/p>\n

\u30b0\u30ec\u30fc\u30c9\u30c0\u30a6\u30f3\u306e\uff15\u3064\u306e\u30c9\u30e1\u30a4\u30f3\u306e\u3046\u3061\u306e\u4e00\u3064\u304c\u3001\u51fa\u7248\u30d0\u30a4\u30a2\u30b9\uff08publication bias\uff09<\/strong>\u3067\u3059\uff08GRADE2\u7248\u306e4.4-4.4.5\u7ae0\u53c2\u7167\uff09\u3002<\/p>\n

\"publication<\/a>
\n<\/p>\n

\u51fa\u7248\u30d0\u30a4\u30a2\u30b9<\/strong>\u306b\u5bfe\u51e6\u3059\u308b\u305f\u3081\u306b\u306f\u3001\uff14\u3064\u306e\u65b9\u6cd5\u304c\u3042\u308a\u307e\u3059\uff08GRADE2\u7248\u53c2\u7167\uff09\u3002<\/p>\n\n\n
\n\uff11\uff0e\u5c0f\u898f\u6a21\u7814\u7a76\u306b\u3088\u3063\u3066\u3088\u308a\u5927\u304d\u306a\u52b9\u679c\u304c\u793a\u3055\u308c\u3066\u3044\u306a\u3044\u304b\u8abf\u3079\u308b (small study effects) \u3002
\n      a\uff0e\u30d5\u30a1\u30f3\u30cd\u30eb\u30d7\u30ed\u30c3\u30c8\u306e\u76ee\u8996\u8a55\u4fa1
\n      b\uff0e\u30d5\u30a1\u30f3\u30cd\u30eb\u30d7\u30ed\u30c3\u30c8\u306e\u7d71\u8a08\u5b66\u7684\u89e3\u6790
\n\uff12\uff0e\u60f3\u5b9a\u3055\u308c\u308b\u51fa\u7248\u30d0\u30a4\u30a2\u30b9\u3092\u628a\u63e1\u3057\u305f\u5f8c\uff0c\u56f3\u5f0f\u3092\u5fa9\u5143\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\uff0c\u30a8\u30d3\u30c7\u30f3\u30b9\u3092\u518d\u69cb\u7bc9\u3059\u308b\u3002
\n      a\uff0eTrim and Fill (Duval and Tweedie)
\n      b\uff0e\u30d5\u30a7\u30a4\u30eb\u30bb\u30fc\u30d5\u6570 fail\u2013safe N (Rosenthal, Orwin)
\n\uff13\uff0e\u7d71\u8a08\u5b66\u7684\u6709\u610f\u6c34\u6e96\u306b\u5fdc\u3058\u305f\uff0c\u51fa\u7248\u306e\u78ba\u7387\u3092\u63a8\u5b9a\u3059\u308b\u3002
\n\uff14\uff0e\u30c7\u30fc\u30bf\u306e\u51fa\u73fe\u306b\u5fdc\u3058\u3066\u7d4c\u6642\u7684\u307e\u305f\u306f\u7814\u7a76\u6570\u306b\u3088\u308b\u52b9\u679c\u30b5\u30a4\u30ba\u306e\u5909\u5316\u3092\u8abf\u3079\u308b\uff08\u7d2f\u7a4d\u30e1\u30bf\u30a2\u30ca\u30ea\u30b9\u3002<\/td>\n<\/tr>\n<\/table>\n

<\/p>\n

\u7814\u7a76\u6570\u304c\u4f55\u4ef6\u3042\u308c\u3070\u3001\u30d5\u30a1\u30f3\u30cd\u30eb\u30d7\u30ed\u30c3\u30c8\u306e\u7d71\u8a08\u5b66\u7684\u89e3\u6790\u304c\u53ef\u80fd\u304b\u3068\u3044\u3046\u70b9\u3067\u306f\u3001\u3044\u304f\u3064\u304b\u306e\u610f\u898b\u304c\u3042\u308b\u3088\u3046\u3067\u3059\u304c\u3001\u30b3\u30af\u30e9\u30f3\u30cf\u30f3\u30c9\u30d6\u30c3\u30af\u3067\u306f10\u4ef6\u4ee5\u4e0a\u3068\u8a18\u8f09\u3055\u308c\u3066\u3044\u307e\u3059\uff08GRADE\u30cf\u30f3\u30c9\u30d6\u30c3\u30af\u3067\u306f5\u4ef6\u4ee5\u4e0a\u306e\u610f\u898b\u3082\u3042\u308a\u3068\u8a18\u8f09\uff09\u3002<\/p>\n

<\/p>\n

\u91cd\u8981\u306a\u3053\u3068\u306f\u3001\u3000\u30d5\u30a1\u30f3\u30cd\u30eb\u30d7\u30ed\u30c3\u30c8\u306b\u304a\u3051\u308b\u975e\u5bfe\u79f0\u6027\uff1d\u51fa\u7248\u30d0\u30a4\u30a2\u30b9\u3067\u306f\u306a\u3044<\/strong><\/span>\u3068\u3044\u3046\u3053\u3068\u3067\u3042\u308a\u3001\u30b3\u30af\u30e9\u30f3\u30cf\u30f3\u30c9\u30d6\u30c3\u30af\uff0810.4.2. Different reasons for funnel plot asymmetry\uff09\u306b\u306fEgger et al\uff081997\uff09\u306e\u4e0b\u8868\u304c\u8a18\u8f09\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

\"asymmetry<\/a>
\n<\/p>\n

\u76ee\u8996\u8a55\u4fa1\u306f\u3042\u307e\u308a\u306b\u3082\u4e3b\u89b3\u7684\u3067\u3042\u308b\u3068\u3044\u3046\u4e3b\u5f35\u304c\u3042\u308a\u307e\u3059\uff08\u30b3\u30af\u30e9\u30f3\u30cf\u30f3\u30c9\u30d6\u30c3\u30af\uff09\u3002\u307e\u305f\u3001\u7d71\u8a08\u5b66\u7684\u306b\u6709\u610f\u3067\u306a\u3044\u7814\u7a76\u304c\u767a\u8868\u3055\u308c\u3066\u3044\u306a\u3044\u306e\u304b\u3069\u3046\u304b\u3092\u628a\u63e1\u3059\u308b\u305f\u3081\u306b\u3001\u8f2a\u90ed\u5f37\u8abf\u30d5\u30a1\u30f3\u30cd\u30eb\u30d7\u30ed\u30c3\u30c8<\/b><\/a>\u3068\u3044\u3046\u624b\u6cd5\u3082\u3042\u308a\u307e\u3059\uff08GRADE2\u7248\u53c2\u7167\uff09\u3002<\/p>\n

\u51fa\u7248\u30d0\u30a4\u30a2\u30b9\u306b\u95a2\u3059\u308b\u6700\u7d42\u8a55\u4fa1\u3068\u3057\u3066\u306f\u3001\u4ee5\u4e0b\u306e\uff13\u3064\u306e\u3044\u305a\u308c\u304b\u306b\u306a\u308a\u307e\u3059\uff08Borentein M, et al. Introduction to Meta-analysis. Wiley, 2009\uff09\u3002GRADE\u3092\u4f7f\u3063\u305f\u8a55\u4fa1\u306e\u5834\u5408\u306f\u3001#3\u304c\u30b0\u30ec\u30fc\u30c9\u30c0\u30a6\u30f3\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n

    \uff11\uff0ethe impact of bias is trivial
\n    2. the impact of bias is not trivial but the major finding is still valid
\n    3. the major finding might be called into question<\/p>\n

<\/p>\n

\u3067\u306f\u3001\u5b9f\u969b\u306eGRADE\u8a3a\u7642\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306b\u304a\u3051\u308b\u51fa\u7248\u30d0\u30a4\u30a2\u30b9\u306e\u8a55\u4fa1\u306f\u3069\u3046\u3067\u3057\u3087\u3046\u3002<\/p>\n\n\n\n
\n\u56fd\u5185\u306eGRADE\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3067\u306f\uff1a<\/b>
\nCQ1\uff1a\u6210\u4ebaARDS \u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u65e9\u671f\u6c17\u7ba1\u5207\u958b\u3092\u884c\u3046\u3079\u304d\u304b\uff08ARDS\u8a3a\u7642\u30ac\u30a4\u30c9\u30e9\u30a4\u30f32016\uff09
\n\u30a2\u30a6\u30c8\u30ab\u30e0\uff1aVAP(10d)
\nARDS\u30d1\u30cd\u30eb\u306f\u3001\u300c10\u4ef6\u306eRCT\u306b\u3088\u308b\u30d5\u30a1\u30f3\u30cd\u30eb\u30d7\u30ed\u30c3\u30c8\u304c\u975e\u5bfe\u79f0\u3067\u3042\u308a\u51fa\u7248\u30d0\u30a4\u30a2\u30b9\u304c\u7591\u308f\u308c\u308b\u304c\u3001\u7d71\u8a08\u5b66\u7684\u691c\u8a0e\u306f\u884c\u3063\u3066\u3044\u306a\u3044<\/strong>\u300d\u3068\u3044\u3046\u5224\u5b9a\u3067\u3059\u3002\u3057\u304b\u3057\u3001\u7d71\u8a08\u5b66\u7684\u306a\u89e3\u6790\u3092\u884c\u3046\u3068\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306b\u51fa\u7248\u30d0\u30a4\u30a2\u30b9\u306f\u5426\u5b9a\u7684\u3067\u3059\u3002<\/td>\n<\/tr>\n
\n\"cq1-funnel\"<\/a>
\n\"cq1-bias\"<\/a>
\n<\/table>\n

\n 
\n<\/p>\n

\u4eee\u60f3\u4f8b\u3067\u306f\u3069\u3046\u3067\u3057\u3087\u3046\u304b\u3002<\/p>\n\n\n\n
\n\u30c8\u30ea\u30d7\u30ebX\u4f8b\u3067\u306f\uff1a<\/b>
\nCQ\uff1a\u8840\u6813\u50be\u5411\u306e\u60a3\u8005\uff08thrombophilia\uff09\u306b\u304a\u3044\u3066\u3001\u7d4c\u53e3\u6297\u8840\u6813\u85ac\u30c8\u30ea\u30d7\u30ebX\uff08XXX\uff09\u3092\u4f7f\u3046\u3079\u304d\u304b\uff1f
\n\u30a2\u30a6\u30c8\u30ab\u30e0\uff1a \u5fc3\u7b4b\u6897\u585e\uff086\u4ef6\u306eRCT\uff09<\/td>\n<\/tr>\n
\n\u51fa\u7248\u30d0\u30a4\u30a2\u30b9\u306a\u3057<\/b>
\n\"xxx-funnel\"<\/a>
\n\"xxx-harbord\"<\/a>
\n\"xxx-bias\"<\/a>
\n<\/table>\n

\n <\/p>\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

[GRADE-CPG\u89e3\u8aac\u8cc7\u6599-\u246d] \u30b0\u30ec\u30fc\u30c9\u30c0\u30a6\u30f3\u306e\uff15\u3064\u306e\u30c9\u30e1\u30a4\u30f3\u306e\u3046\u3061\u306e\u4e00\u3064\u304c\u3001\u51fa\u7248\u30d0\u30a4\u30a2\u30b9\uff08publication bias\uff09\u3067\u3059\uff08GRADE2\u7248\u306e4.4-4.4.5\u7ae0\u53c2\u7167\uff09\u3002 \u51fa\u7248\u30d0\u30a4\u30a2\u30b9\u306b\u5bfe\u51e6\u3059\u308b\u305f\u3081\u306b\u306f\u3001\uff14\u3064\u306e […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[455,5,55],"tags":[],"_links":{"self":[{"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/posts\/4790"}],"collection":[{"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=4790"}],"version-history":[{"count":32,"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/posts\/4790\/revisions"}],"predecessor-version":[{"id":8994,"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/posts\/4790\/revisions\/8994"}],"wp:attachment":[{"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=4790"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=4790"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=4790"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}