{"id":70,"date":"2008-02-01T15:11:51","date_gmt":"2008-02-01T06:11:51","guid":{"rendered":"http:\/\/aihara.la.coocan.jp\/blog\/?p=70"},"modified":"2014-04-16T15:35:26","modified_gmt":"2014-04-16T06:35:26","slug":"%e3%82%bf%e3%83%9f%e3%83%95%e3%83%ab-pros-and-cons-3%ef%bc%88%e5%b0%8f%e5%85%90%ef%bc%89","status":"publish","type":"post","link":"http:\/\/aihara.la.coocan.jp\/?p=70","title":{"rendered":"\u30bf\u30df\u30d5\u30eb pros and cons-3\uff08\u5c0f\u5150\uff09"},"content":{"rendered":"<div>\n<p>\u30bf\u30df\u30d5\u30eb\u306e\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u306b\u3064\u3044\u3066\u306e\u52b9\u679c\u30fb\u5bb3\u306b\u95a2\u3057\u3066\u3001GRADE\u30b7\u30b9\u30c6\u30e0\u3092\u5229\u7528\u3057\u3066\u8003\u3048\u3066\u307f\u305f\u3044\u3068\u601d\u3044\u307e\u3059\u3002\u3064\u307e\u308a\u3001\u30bf\u30df\u30d5\u30eb\u306e\u5bb3\u3068\u3057\u3066\u3088\u304f\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3001\u5614\u5410\u3001\u3042\u308b\u3044\u306f\u3053\u3053\u6570\u5e74\u3067\u554f\u984c\u306b\u306a\u3063\u3066\u3044\u308b\u7570\u5e38\u884c\u52d5\u3068\u3044\u3046\u30a2\u30a6\u30c8\u30ab\u30e0\u3092\u4e3b\u4f53\u3068\u3057\u3066\u3001benefit\u3068\u6bd4\u8f03\u3057\u3066\u307f\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002<\/p>\n<p><\/p>\n<p>\u30bf\u30df\u30d5\u30eb\u4e2d\u6b62\u3059\u3079\u304d\u3068\u3044\u3046\u6d5c\u6c0f\u306e\u767a\u8868\u3042\u308b\u3044\u306f\u3001\u56e0\u679c\u95a2\u4fc2\u672a\u89e3\u6c7a\u3068\u3044\u3046\u539a\u751f\u52b4\u50cd\u7814\u7a76\u73ed\u306e\u30c7\u30fc\u30bf\u306b\u3064\u3044\u3066\u3082\u8003\u3048\u3066\u307f\u305f\u3044\u3068\u601d\u3044\u307e\u3059\u3002\u79c1\u306e\u500b\u4eba\u7684\u306a\u8003\u3048\u3067\u3059\u306e\u3067\u3001\u5229\u7528\u30c7\u30fc\u30bf\u306b\u95a2\u3057\u3066\u306f\u5225\u306e\u8003\u3048\u304c\u3042\u308b\u4eba\u3082\u3044\u308b\u3067\u3057\u3087\u3046\u304c\u3001\u3053\u306e\u70b9\u306b\u3064\u3044\u3066\u8b70\u8ad6\u3092\u5c55\u958b\u3059\u308b\u3064\u3082\u308a\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u500b\u4eba\u306e\u30d6\u30ed\u30b0\u3067\u3059\u304b\u3089\u306d\u3002<\/p>\n<p><\/p>\n<p><b>\u8abf\u67fb\u30fb\u6bd4\u8f03\u306e\u65b9\u6cd5<\/b>\u3068\u3057\u3066\u306f\u3001Cochrane lib, UTD, EBM-GL,\u88fd\u85ac\u4f1a\u793e\uff08\u4e2d\u5916\u3001\u6d77\u5916Roche)\u516c\u958b\u8cc7\u6599\u3001pubMed,\u533b\u5b66\u4e2d\u592e\u96d1\u8a8c\u3001\u8ad6\u6587\u304b\u3089\u306e\u30b5\u30d6\u30cf\u30f3\u30c9\u30b5\u30fc\u30c1\u3001\u3068\u3057\u307e\u3057\u305f\u3002<\/p>\n<p><\/p>\n<p><b>\u5bfe\u8c61<\/b>\u306f\u3001\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u60a3\u8005\u306e\u6cbb\u7642\u306b\u304a\u3051\u308b\u30bf\u30df\u30d5\u30eb\u6bd4\u8f03\u4f8b\u3001\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u4e88\u9632\u3067\u306e\u30bf\u30df\u30d5\u30eb\u6bd4\u8f03\u4f8b\u3067\u3001\u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a13\u3001\u89b3\u5bdf\u7814\u7a76\u3001\u75c7\u4f8b\u5bfe\u7167\u7814\u7a76\u3001\u3068\u3057\u307e\u3057\u305f\uff08\u5e74\u9f62\u306f\u30011-12\u6b73\u306e\u5c0f\u5150\u300113\u6b73\u4ee5\u4e0a\u306e\u5927\u4eba\u306e2\u7fa4\u3067\u308f\u3051\u3066\u89e3\u6790\uff09\u3057\u307e\u3057\u305f\u3002\uff08\u7570\u5e38\u884c\u52d5\u306e\u5b9a\u7fa9\u306a\u3069\u306f\u3001\u5f8c\u3067\u5217\u8a18\uff09\u3002\u4e00\u90e8\u3001\u52d5\u7269\u5b9f\u9a13\u3067\u306e\u6bd4\u8f03\u8a66\u9a13\u3082\u63a1\u7528\u3057\u3066\u691c\u8a0e\u3057\u307e\u3057\u305f\u304c\u3001\u56fd\u5185\u8ad6\u6587\u3067\u767a\u8868\u3055\u308c\u3066\u3044\u308b\u30c7\u30fc\u30bf\u3068\u306e\u76f8\u9055\u306b\u3064\u3044\u3066\u3082\u8003\u3048\u305f\u3044\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n<p><\/p>\n<p><b>\u56f3\uff11 \u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9<\/b><br \/>\n<a href=\"http:\/\/aihara.la.coocan.jp\/tamiflu-ped-1.php\" onclick=\"window.open('http:\/\/aihara.la.coocan.jp\/tamiflu-ped-1.php','popup','width=580,height=309,scrollbars=no,resizable=no,toolbar=no,directories=no,location=no,menubar=no,status=no,left=0,top=0'); return false\"><img decoding=\"async\" loading=\"lazy\" src=\"http:\/\/aihara.la.coocan.jp\/tamiflu-ped-1-thumb.jpg\" width=\"200\" height=\"106\" alt=\"tamiflu\" \/><\/a>\n<\/p>\n<p><br clear=\"all\" \/><\/p>\n<p><b>\u25a0outcome-1: \u5c0f\u5150\u3067\u306e\u5614\u5410<\/b>\uff08\u56f3\uff11\uff09<br \/>\n<b>\u25cf<\/b>&nbsp;\u63a1\u7528\u7814\u7a76\uff1aRCT\uff13\uff08\u6cbb\u7642\uff1aWV15758, WV15759\u3001\u4e88\u9632<br \/>\n<a href=\"http:\/\/www.fda.gov\/cder\/foi\/label\/2008\/021087s042,021246s030lbl.pdf\">Roche file 2008-Jan<\/a>,CDSR 2007\u3001phase-III\u8a66\u9a13\u306e\u767a\u8868\u8ad6\u6587\u306a\u3069\u91cd\u8907\u8ad6\u6587\u3042\u308a)<br \/>\n<b>\u25cf<\/b>&nbsp;\u51683\u4ef6\u3067\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u30ea\u30b9\u30af\u304c\u6cbb\u7642\u4f8b\u3068\u4e88\u9632\u4f8b\u3068\u3067\u306f\u7570\u306a\u308b\u3082\u306e\u306e\u3001\u7d71\u5408\u3057\u305f\u3082\u306e\u3067\u306f\u3001general variance-based method, DerSimonian-Laird method,\u3044\u305a\u308c\u3067\u3082\u5747\u8cea\u6027\u68c4\u5374\u3055\u308c\u305a\uff08p=0.0026)\u3002<br \/>\n<b>\u25cf<\/b>&nbsp;\u73fe\u5728\u306e\u56fd\u5185\u72b6\u6cc1\u3067\u3001\u30bf\u30df\u30d5\u30eb\u3092\u4e88\u9632\u6295\u4e0e\u3059\u308b\u3053\u3068\u306f\u81ea\u5206\u306e\u74b0\u5883\u3067\u306f\u3042\u308a\u3048\u306a\u3044\u306e\u3067\u3001&#8221;\u4e88\u9632&#8221;\u6295\u4e0e\u3067\u306e\u5614\u5410\u306e\u30a2\u30a6\u30c8\u30ab\u30e0\u306f\u3001\u30ec\u30d9\u30eb\uff13\uff08not important\uff09\u3068\u3057\u3001\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6&#8221;\u6cbb\u7642&#8221;\u4f8b\u3067\u306e\u5614\u5410\u3092\u91cd\u8981\uff08important\uff09\u3068\u3057\u305f\u3002<br \/>\n<b>\u25cf<\/b>&nbsp;\u30bf\u30df\u30d5\u30eb&#8221;\u6cbb\u7642&#8221;\u5c0f\u5150\u4f8b\u3067\u9650\u308b\u3068\u3001\u76f8\u5bfe\u5371\u967a\uff08RR\uff09\u306f\u30011.58(95%CI= 1.12\uff5e2.22)\u3001p=0.008(\u30e9\u30f3\u30c0\u30e0\u52b9\u679c\u30e2\u30c7\u30eb)\u3002\u3057\u304b\u3057\u3001\u7814\u7a76\u6570\uff08\u30a4\u30d9\u30f3\u30c8\u6570\u3092\u542b\u3081\uff09\u304c\u5c11\u306a\u3044\u3068\u3044\u3046\u554f\u984c\u304c\u3042\u308b\u3002<\/p>\n<p><\/p>\n<p><b>\u56f3\uff12 \u30a8\u30d3\u30c7\u30f3\u30b9\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb<\/b><br \/>\n<a href=\"http:\/\/aihara.la.coocan.jp\/GRADE-tamiflu-pediat1.php\" onclick=\"window.open('http:\/\/aihara.la.coocan.jp\/GRADE-tamiflu-pediat1.php','popup','width=986,height=549,scrollbars=no,resizable=no,toolbar=no,directories=no,location=no,menubar=no,status=no,left=0,top=0'); return false\"><img decoding=\"async\" loading=\"lazy\" src=\"http:\/\/aihara.la.coocan.jp\/GRADE-tamiflu-pediat-thumb.jpg\" width=\"200\" height=\"111\" alt=\"ep\" \/><\/a>\n<\/p>\n<p><br clear=\"all\" \/><\/p>\n<p><b>\u7d50\u8ad6\uff1b\u3000\u5c0f\u5150\uff081-12\u6b73\uff09\u3067\u306f\u3001\u30bf\u30df\u30d5\u30eb\u6295\u4e0e\u3067\u3001\u5614\u5410\u304c\u591a\u3044\u3002<br \/>\n[GRADE evidence level= moderate]<\/b><br \/>\nGRADE system \u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u30fb\u30d7\u30ed\u30d5\u30a3\u30fc\u30eb\u306f\u56f3\uff12\u53c2\u7167\u3002<\/p>\n<p><\/p>\n<p>\u306a\u304a\u3001\u4e0b\u8a18\u306f\u9664\u5916\u7814\u7a76\u306e\u4e00\u90e8\u3068\u305d\u306e\u7406\u7531\u3067\u3059\u3002<br \/>\n(1)JV16284\uff08\u56fd\u5185\u7814\u7a76\uff1a\u3000\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u304c\u306a\u3044\u89b3\u5bdf\u7814\u7a76\uff09<br \/>\n(2)\u539a\u751f\u52b4\u50cd\u7814\u7a76\u73ed\uff08\u6a2a\u7530\uff09\uff1a\u30b3\u30f3\u30c8\u30fc\u30eb\u306e\u306a\u3044\u75c7\u4f8b\u30b7\u30ea\u30fc\u30ba\u3001\u4e8b\u5f8c\u89e3\u6790\u6570\u306e\u591a\u3055\uff08\u5f8c\u65e5\u3001\u8a73\u7d30\u30b3\u30e1\u30f3\u30c8\u8ffd\u52a0\uff09<br \/>\n(3)TIP 2007\u8ad6\u6587\uff08\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u306e\u306a\u3044\u75c7\u4f8b\u30b7\u30ea\u30fc\u30ba\u304b\u3089\u3001RCT\u306b\u6e96\u3058\u305f\u89e3\u6790\u3092\u5b9f\u65bd\u3001\u5f8c\u65e5\u3055\u3089\u306b\u30b3\u30e1\u30f3\u30c8\uff09<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u30bf\u30df\u30d5\u30eb\u306e\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u306b\u3064\u3044\u3066\u306e\u52b9\u679c\u30fb\u5bb3\u306b\u95a2\u3057\u3066\u3001GRADE\u30b7\u30b9\u30c6\u30e0\u3092\u5229\u7528\u3057\u3066\u8003\u3048\u3066\u307f\u305f\u3044\u3068\u601d\u3044\u307e\u3059\u3002\u3064\u307e\u308a\u3001\u30bf\u30df\u30d5\u30eb\u306e\u5bb3\u3068\u3057\u3066\u3088\u304f\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3001\u5614\u5410\u3001\u3042\u308b\u3044\u306f\u3053\u3053\u6570\u5e74\u3067\u554f\u984c\u306b\u306a\u3063\u3066\u3044\u308b\u7570\u5e38\u884c\u52d5\u3068\u3044\u3046\u30a2\u30a6\u30c8\u30ab\u30e0\u3092\u4e3b\u4f53 [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[13],"tags":[20,91],"_links":{"self":[{"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/posts\/70"}],"collection":[{"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=70"}],"version-history":[{"count":1,"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/posts\/70\/revisions"}],"predecessor-version":[{"id":612,"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/posts\/70\/revisions\/612"}],"wp:attachment":[{"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=70"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=70"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=70"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}