{"id":74,"date":"2008-02-04T16:10:43","date_gmt":"2008-02-04T07:10:43","guid":{"rendered":"http:\/\/aihara.la.coocan.jp\/blog\/?p=74"},"modified":"2014-04-16T15:35:10","modified_gmt":"2014-04-16T06:35:10","slug":"%e3%82%bf%e3%83%9f%e3%83%95%e3%83%ab-pros-and-cons-7-%ef%bc%88%e6%9c%89%e5%8a%b9%e6%80%a7%e3%81%ae%e3%82%a8%e3%83%93%e3%83%87%e3%83%b3%e3%82%b9%ef%bc%89","status":"publish","type":"post","link":"http:\/\/aihara.la.coocan.jp\/?p=74","title":{"rendered":"\u30bf\u30df\u30d5\u30eb pros and cons-7 \uff08\u6709\u52b9\u6027\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\uff09"},"content":{"rendered":"<div>\n<p>\u25a0\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u60a3\u8005\u306e\u30bf\u30df\u30d5\u30eb\u51e6\u65b9\u983b\u5ea6\u306f\u3001\u539a\u751f\u52b4\u50cd\u7814\u7a76\u73ed\u306e\u767a\u8868\u304b\u3089\u63a8\u6e2c\u3067\u304d\u307e\u3059\u3002\u5e73\u621017\u5e74\u5831\u544a\uff08\u6a2a\u7530\uff1b\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u306b\u4f34\u3046\u968f\u4f34\u75c7\u72b6\u306e\u767a\u73fe\u72b6\u6cc1\u306b\u95a2\u3059\u308b\u8abf\u67fb\u7814\u7a76\uff09\u3067\u306f\u30bf\u30df\u30d5\u30eb\u51e6\u65b9\u306f90%\u3067\u3001\u5e73\u621019\u5e74\u3067\u306f\uff08\u7d041\u4e07\u4eba\uff0978%\u3067\u3059\u3002\u30bf\u30df\u30d5\u30eb\u3068\u3001\u3044\u308f\u3086\u308b\u7570\u5e38\u884c\u52d5\u3068\u306e\u95a2\u9023\u8abf\u67fb\u3067\u306f\u3001\u975e\u6295\u4e0e\u7fa4\u3067\u306f12%\u3001\u30bf\u30df\u30d5\u30eb\u6295\u4e0e\u7fa4\u3067\u306f16%\u3067\u3059\u304c\u3001\u3053\u306e\u4e21\u8005\u306e\u30c7\u30fc\u30bf\u3092\u5358\u9806\u306b\u6bd4\u8f03\u3059\u308b\u3053\u3068\u306f\u597d\u307e\u3057\u304f\u306a\u304f\u3001\u5b9f\u969b\u306e\u81e8\u5e8a\u3067\u4e3b\u6cbb\u533b\u304c\u3069\u306e\u3088\u3046\u306b\u3057\u3066\u60a3\u8005\u3092\u767b\u9332\u3057\u305f\u304b\u3092\u60f3\u50cf\u3059\u308b\u3068\u3059\u3050\u306b\u7406\u89e3\u3067\u304d\u307e\u3059\u3002<\/p>\n<p><\/p>\n<p>\n\u25a0\u672c\u7814\u7a76\u73ed\u306e\u8abf\u67fb\u306b\u304a\u3044\u3066\u306f\u3001\u5358\u306b\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u3068\u8fc5\u901f\u691c\u67fb\u3067\u8a3a\u65ad\u3057\u305f\u60a3\u8005\u306b\u3064\u3044\u3066\u3001\uff08\u8abf\u67fb\u306e\u540c\u610f\u3092\u5f97\u3066\uff09\u3001\u8a3a\u7642\u3057\u307e\u3059\u3002\u305d\u3057\u3066\u3001\u30bf\u30df\u30d5\u30eb\u51e6\u65b9\u3001\u975e\u51e6\u65b9\u306b\u304b\u304b\u308f\u3089\u305a\u3001\u89b3\u5bdf\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\n&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;-<\/p>\n<p><\/p>\n<p>\u30fb\u3042\u308b\u60a3\u8005\u306f\u3001\u6765\u9662\u5f53\u65e5\u306e\u671d\u306b\u9ad8\u71b1\u304c\u3042\u3063\u305f\u3082\u306e\u306e\u53d7\u8a3a\u6642\u306b\u306f\u89e3\u71b1\u3057\u3066\u5143\u6c17\u3060\u304c\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u691c\u67fb\u304c\u967d\u6027\u3060\u3063\u305f\u3002\u2192\u3000\u4e3b\u6cbb\u533b\u306e\u5bfe\u5fdc\u306f\u3001\u30bf\u30df\u30d5\u30eb\u975e\u6295\u4e0e\u3067\u89b3\u5bdf\u3002<br \/>\n\u30fb\u5225\u306e\u60a3\u8005\u306f\u3001\u6765\u9662\u53d7\u8a3a\u6642\u306b\u767a\u71b1\u304c\u3042\u3063\u3066\u3001\u691c\u67fb\u3067\u967d\u6027\u3067\u3042\u3063\u305f\u304c\u3001\u4e3b\u6cbb\u533b\u306f\u30bf\u30df\u30d5\u30eb\u51e6\u65b9\u3092\u305b\u305a\u3001\u89b3\u5bdf\u3057\u305f\u3002<br \/>\n\u30fb\u3055\u3089\u306b3\u4f8b\u76ee\u306f\u3001\u767a\u71b1\u306f\u4e00\u6642\u7684\u3067\u3001\u691c\u67fb\u304c\u967d\u6027\u3067\u3042\u308a\u3001\u89aa\u306e\u5e0c\u671b\u3067\u3001\u30bf\u30df\u30d5\u30eb\u3092\u51e6\u65b9\u3057\u305f\u3002<br \/>\n\u30fb4\u4f8b\u76ee\u306f\u3001\u9ad8\u71b1\u304c\u3042\u308a\u6765\u9662\u3001\u691c\u67fb\u304c\u967d\u6027\u3067\u3001\u4e3b\u6cbb\u533b\u306f\u30ea\u30ec\u30f3\u30b6\u3092\u51e6\u65b9\u3057\u305f\u3002<br \/>\n&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<\/p>\n<p><\/p>\n<p>\u3053\u306e\u3088\u3046\u306b\u3057\u3066\u3001<b>\u9023\u7d9a\u3057\u306610\u4f8b\uff5e20\u4f8b\u3092\u767b\u9332<\/b>\u3059\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3001\u7814\u7a76\u30c7\u30b6\u30a4\u30f3\u3068\u3057\u3066\u306f\u591a\u304f\u306e\u30d0\u30a4\u30a2\u30b9\u56e0\u5b50\u304c\u3042\u308a\u3001\u5168\u304f\u30e9\u30f3\u30c0\u30e0\u5272\u4ed8\u3068\u306f\u3044\u3048\u306a\u3044\u3082\u306e\u3067\u3059\u3002\u3053\u306e\u7d50\u679c\u304b\u3089\u306f\u3001\u5358\u306b\u983b\u5ea6\u3060\u3051\u3057\u304b\u77e5\u308a\u3048\u306a\u3044\u3057\u3001\u4fe1\u983c\u533a\u9593\u3092\u63a8\u5b9a\u3057\u3066\u3082\u3001\u305d\u306e\u30c7\u30fc\u30bf\u306e\u307f\u304b\u3089\u5f97\u3089\u308c\u308b\u3082\u306e\u3067\u3042\u308a\u3001\u4f8b\u6570\u304c\u5897\u3048\u308b\u3068\u3001\u4fe1\u983c\u533a\u9593\u304c\u72ed\u304f\u306a\u308b\u3068\u3044\u3046\u3060\u3051\u306e\u8a71\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n<p><\/p>\n<p>2000\u4eba\u3092\u3001\u3042\u308b\u3044\u306f1\u4e07\u4eba\u3092\u3001\u5e74\u6708\u306b\u308f\u305f\u3063\u3066\u89b3\u5bdf\u3059\u308b\u3068\u3044\u3046\u7814\u7a76\u3068\u306f\u9055\u3044\u307e\u3059\u3002\u3057\u304b\u3082\u3001\u6211\u3005\u304c\u77e5\u308a\u305f\u3044\u306e\u306f\u3001\u7279\u306b\u6295\u85ac\uff11\uff5e\uff12\u65e5\u4ee5\u5185\u306e\u7570\u5e38\u884c\u52d5\u306e\u5dee\u3067\u3059\u3002<\/p>\n<p><\/p>\n<p>\u5f93\u3063\u3066\u3001\u4e16\u754c\u4e2d\u3067\u65e5\u672c\u304c\u4e00\u756a\u30bf\u30df\u30d5\u30eb\u3092\u51e6\u65b9\u3057\u3066\u3044\u308b\u56fd\u3067\u3042\u308b\u4ee5\u4e0a\u306f\u3001\u51e6\u65b9\u3059\u308b\u3053\u3068\u304c\u975e\u502b\u7406\u7684\u3068\u8a00\u308f\u308c\u308b\u3053\u3068\u306f\u306a\u3044\u3067\u3057\u3087\u3046\u3057\u3001<b>\u4e21\u8005\u306e\u5dee\u304b\u3089\u3001\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u3092\u7b97\u51fa\u3057\u3066\u3001\u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a13\u3092\u5b9f\u65bd\u3059\u308b\u3053\u3068<\/b>\u304c\u4e00\u756a\u65e9\u9053\u3068\u601d\u3044\u307e\u3059\u304c\u3001\u7814\u7a76\u73ed\u3067\u306f\u4eca\u5f8c\u306f\u3053\u308c\u307e\u3067\u306e\u84c4\u7a4d\u3055\u308c\u305f\u4f8b\u3067\u89e3\u6790\u3059\u308b\u3068\u3044\u3046\u65b9\u91dd\u306e\u3088\u3046\u3067\u3059\u3002<\/p>\n<p><\/p>\n<p>\u03b1=0.05, \u03b2=0.8\u3068\u3057\u3066\u3001\u5404\u7fa41500\u4eba\u5f31\u306e\u3082\u306e\u3067\u6bd4\u8f03\u3067\u304d\u308b\u3082\u306e\u3092\u3001\u3069\u3046\u3057\u3066\u8a08\u753b\u3057\u306a\u3044\u306e\u304b\u7406\u89e3\u304c\u3067\u304d\u307e\u305b\u3093\u3002\u30e9\u30f3\u30c0\u30e0\u5316\u8a66\u9a13\u306f\u975e\u502b\u7406\u7684\u3068\u3044\u3046\u65b9\u3082\u3044\u307e\u3059\u304c\u3001\u305d\u308c\u3067\u306f\u3001\u7814\u7a76\u73ed\u8abf\u67fb\u3067\u5831\u544a\u3055\u308c\u305f8000\u4eba\u8fd1\u304f\u306e\u60a3\u8005\u304c\u975e\u502b\u7406\u7684\u306a\u533b\u7642\u3092\u53d7\u3051\u305f\u3053\u3068\u306b\u306a\u3063\u3066\u3057\u3044\u307e\u3059\u3002\u4eca\u5f8c\u3082\u7814\u7a76\u73ed\u304c\u7d99\u7d9a\u3059\u308b\u30b1\u30fc\u30b9\u30b7\u30ea\u30fc\u30ba\u3068\u3044\u3046\u3000very low level\u306e\u7814\u7a76\u30c7\u30b6\u30a4\u30f3\u306e\u81a8\u5927\u306a\u7d50\u679c\u3092\u3001\u5f8c\u4ed8\u3067\u3044\u308d\u3044\u308d\u3068\u51e6\u7406\u3057\u3066\u3082\u3001\u5f97\u3089\u308c\u308b\u306e\u30c7\u30fc\u30bf\u306f\u4fe1\u983c\u6027\u304c\u4f4e\u3044\u3082\u306e\u306b\u5909\u308f\u308a\u306a\u3044\u3068\u601d\u308f\u308c\u307e\u3059\u3002<\/p>\n<p><\/p>\n<p>\u3061\u306a\u307f\u306b\u3001\u5f53\u9662\u3067\u306e10\u6570\u4f8b\u3067\u306e\u9023\u7d9a\u3057\u305f\u89b3\u5bdf\u3067\u306f\u3001\u30bf\u30df\u30d5\u30eb\u51e6\u65b9\u3067\u306f\u7570\u5e38\u884c\u52d5\u306f\u306a\u304f\u3001\u975e\u6295\u4e0e\u30671\u4f8b\u3001\u30ea\u30ec\u30f3\u30b6\u30671\u4f8b\u89b3\u5bdf\u3055\u308c\u305f\u3002\u30ea\u30ec\u30f3\u30b6\u4f8b\u3067\u306f\u30011\u56de\u4f7f\u7528\u5f8c\u3067\u3059\u3002<\/p>\n<p><\/p>\n<p><b>Cochrane \u30ec\u30d3\u30e5\u30fc\u3092\u5229\u7528\u3057\u305fEBM-Guideline<\/b>\u3067\u306f\u3001\u3069\u306e\u3088\u3046\u306a\u8a55\u4fa1\uff08GRADE\u5206\u985e\uff09\u306b\u306a\u3063\u3066\u3044\u308b\u306e\u304b\u3068\u3044\u3046\u3068\u3001\u56f3\u306e\u3088\u3046\u306a\u5224\u5b9a\u3067\u3059(CDSR 2007)\u3002<br \/>\n\u307e\u305f\u3001\u5c0f\u5150\u30fb\u6210\u4eba\u5168\u4f53\u3067\u306e\u5831\u544a\u3082\u3042\u308a\u7d4c\u6e08\u8a55\u4fa1\u3082\u8a18\u8f09\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u3053\u3053\u3067\u306f\u7701\u7565\u3057\u307e\u3059\u3002<\/p>\n<p><\/p>\n<p>\n<a href=\"http:\/\/aihara.la.coocan.jp\/tamiflu-GRADE1.php\" onclick=\"window.open('http:\/\/aihara.la.coocan.jp\/tamiflu-GRADE1.php','popup','width=501,height=600,scrollbars=no,resizable=no,toolbar=no,directories=no,location=no,menubar=no,status=no,left=0,top=0'); return false\"><img decoding=\"async\" loading=\"lazy\" src=\"http:\/\/aihara.la.coocan.jp\/tamiflu-GRADE1-thumb.jpg\" width=\"250\" height=\"299\" alt=\"OSR-GRADE\" \/><\/a>\n<\/p>\n<p><br clear=\"all\" \/><\/p>\n<p>\u79c1\u898b\u3068\u3057\u3066\u307e\u3068\u3081\u308b\u3068\u3001<br \/>\n<b>(1)<\/b> \u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u60a3\u8005\u306b\u5bfe\u3057\u3066\u306e\u30bf\u30df\u30d5\u30eb\u6295\u4e0e\u306f\u3001\u6295\u4e0e\u6642\u671f\u304c\u65e9\u671f\u306e\u5834\u5408\u306b\u9650\u3063\u3066\u3001\u767a\u71b1\u671f\u9593\u30921\u65e5\u7a0b\u5ea6\u77ed\u7e2e\u3059\u308b\u3060\u3051\u3067\u3042\u308a\u3001\u308f\u305a\u304b\u306a\u52b9\u679c\u306b\u3059\u304e\u306a\u3044\u3002<br \/>\n<b>(2)<\/b> \u5065\u5eb7\u6210\u4eba\u306e\u901a\u5e38\u306e\uff08\u975e\u30d1\u30f3\u30c7\u30df\u30c3\u30af\uff09\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u306b\u306f\u3001\u6cbb\u7642\u30fb\u4e88\u9632\u3067\u3082\u9069\u5fdc\u3067\u306f\u306a\u3044\u3002<br \/>\n<b>(3)<\/b> \u30bf\u30df\u30d5\u30eb\u6295\u4e0e\u3059\u308b\u3068\u3001\u5614\u5410\u304c\u5c0f\u5150\u30fb\u6210\u4eba\u60a3\u8005\u3067\u591a\u3044\uff08\u7b2c1\uff5e2\u75c5\u65e5\uff09\u3002\u5f93\u3063\u3066\u3001\u30bf\u30df\u30d5\u30eb\u306e\u6295\u85ac\uff08\u85ac\u5264\u3060\u3051\u306e\u4fa1\u683c4300\u5186\u3092\u8003\u616e\u3057\u3066\u3082\uff09\u306f\u3001\u30e1\u30ea\u30c3\u30c8\u306b\u307f\u3042\u3063\u305f\u3082\u306e\u3067\u306f\u306a\u3044\u3060\u308d\u3046\u3002<br \/>\n<b>(4)<\/b> \u30bf\u30df\u30d5\u30eb\u3068\u4e2d\u67a2\u795e\u7d4c\u6709\u5bb3\u4e8b\u8c61\u306f\u3053\u308c\u307e\u3067\u306e\u8cea\u306e\u9ad8\u3044\u7814\u7a76\u304b\u3089\u306f\u3001\u95a2\u9023\u6027\u304c\u660e\u3089\u304b\u3067\u306a\u3044\u3002<br \/>\n<b>(5)<\/b>\u56fd\u5185\u5916\u306e\u8a66\u9a13\u3067\u306f\u3001\u30bf\u30df\u30d5\u30eb\u8010\u6027\u30a6\u30a4\u30eb\u30b9\u306e\u51fa\u73fe\u304c\u3001\u5c0f\u5150\u3067\u7d044%\u3002<br 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