{"id":79,"date":"2008-02-15T14:38:28","date_gmt":"2008-02-15T05:38:28","guid":{"rendered":"http:\/\/aihara.la.coocan.jp\/blog\/?p=79"},"modified":"2014-04-16T15:35:09","modified_gmt":"2014-04-16T06:35:09","slug":"%e7%97%87%e4%be%8b%e5%af%be%e7%85%a7%e7%a0%94%e7%a9%b6%e3%81%a8grade%e3%81%ae%e8%b3%aa","status":"publish","type":"post","link":"http:\/\/aihara.la.coocan.jp\/?p=79","title":{"rendered":"\u75c7\u4f8b\u5bfe\u7167\u7814\u7a76\u3068GRADE\u306e\u8cea"},"content":{"rendered":"
\n

GRADE\u3067\u306f\u3001\u63a8\u5968\u5ea6\u3068\u3001\u30a8\u30d3\u30c7\u30f3\u30b9\u306e\u8cea\u3092\u5206\u96e2<\/b>\u3057\u3066\u3044\u307e\u3059\u3002\u3000\u3059\u306a\u308f\u3061\u3001\u3044\u304b\u306b\u3059\u3050\u308c\u305f\u3000\u201dRCT\u304c\u591a\u6570\u201d\u3067\u3082\u3001\u201d\u5f37\u3044\u63a8\u5968\u201d\u306b\u306f\u3000\u306a\u3089\u306a\u3044\u5834\u5408\u3082\u3042\u308a\u3001\u30a8\u30d3\u30c7\u30f3\u30b9\u30ec\u30d9\u30eb\u306e\u968e\u5c64\u7684\u306b\u306f\u4e0b\u4f4d\u3068\u5224\u65ad\u3055\u308c\u3066\u3044\u305f\u75c7\u4f8b\u5bfe\u7167\u7814\u7a76\u306a\u3069\u306e\u89b3\u5bdf\u7814\u7a76<\/b>\u3067\u3082\u3001\u52b9\u679c\u306e\u7a0b\u5ea6\u3084\u3000\u4ea4\u7d61\u56e0\u5b50\u3001\u7528\u91cf\u52fe\u914d\u53cd\u5fdc\u306a\u3069\u306b\u3088\u3063\u3066\u306f\u3001\u5f37\u3044\u63a8\u5968\u306b\u306a\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002
\n\u73fe\u5b9f\u306e\u81e8\u5e8a\u3067\u306f\u3001\u3042\u305f\u308a\u307e\u3048\u3068\u3044\u3048\u3070\u3000\u3042\u305f\u308a\u307e\u3048\u306a\u3093\u3067\u3059\u304c\u30fb\u30fb\u30fb\u30fb<\/p>\n

<\/p>\n

\u75c7\u4f8b\u5bfe\u7167\u7814\u7a76\u306b\u9650\u5b9a\u3057\u3066\u3082\u3001\u56fd\u5185\u306e\u591a\u304f\u306e\u7814\u7a76\u306f\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3084\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u306e\u8a2d\u5b9a\u306a\u3069\u4e0d\u5099\u306a\u3082\u306e\u304c\u591a\u304f\u3001\u904e\u53bb\u306e\u30ab\u30eb\u30c6\u8abf\u67fb\u304b\u3089\u304f\u308b\u5b89\u6613\u306a\u3082\u306e\u304c\u591a\u3044\u3068\u601d\u3044\u307e\u3059\u3002\u901a\u5e38GRADE\u3067\u306f\u3001\u3053\u306e\u3088\u3046\u306a\u89b3\u5bdf\u7814\u7a76\uff08\u8907\u6570\uff09\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u306fvery low quality<\/b>\u3067\u3059\u3002\u3057\u304b\u3057\u3001
\n\u56fd\u5185\u306e\u826f\u8cea\u306a\u75c7\u4f8b\u5bfe\u7167\u7814\u7a76\u3068\u3057\u3066\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u3082\u306e\u304c\u3042\u308a\u307e\u3059\u3002
\n———————————————————————
\n\u4f50\u85e4\u55e3\u9053\u3001\u4e45\u4fdd\u7530\u6f54\u3001\u300c\u65e5\u672c\u306b\u304a\u3051\u308b\u4e0a\u90e8\u6d88\u5316\u7ba1\u51fa\u8840\u3068\u975e\u30b9\u30c6\u30ed\u30a4\u30c9\u6297\u708e\u75c7\u85ac\uff08NSAIDs)\u306e\u95a2\u4fc2\u306b\u95a2\u3059\u308b\u30b1\u30fc\u30b9\u30fb\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u7814\u7a76\u300d\u306f\u3044\u304b\u306b\u5b9f\u65bd\u3055\u308c\u305f\u304b\uff1f<\/b>\u85ac\u5264\u75ab\u5b66\u30002006; 11: 53-65.
\n———————————————————————<\/p>\n

<\/p>\n

\u8981\u7d04\u306f\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u3082\u306e\u3067\u3059\u3002
\n\u25a0\u4e0a\u90e8\u6d88\u5316\u7ba1\u51fa\u8840(UGIB)\u3068NSAIDs\u306e\u95a2\u4fc2\u306b\u95a2\u3059\u308b\u30b1\u30fc\u30b9\u30fb\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u7814\u7a76\u3092\u5b9f\u65bd\u3057\u3001\u30a2\u30b9\u30d4\u30ea\u30f3\u3042\u308b\u3044\u306f\u30a2\u30b9\u30d4\u30ea\u30f3\u4ee5\u5916\u306eNSAIDs\u4f7f\u7528\u306eUGIB\u306e\u30aa\u30c3\u30ba\u6bd4\u306f\u3001\u5404\u3005 5.5(95%CI 2.5-11.9), 6.1(2.7-13.4)\u3067\u3042\u3063\u305f\u3002<\/b><\/p>\n

\u3053\u306e\u8ad6\u6587\u306e\u3059\u3070\u3089\u3057\u3055\u306f\u3001\u4e8b\u524d\u306b\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u3092\u898b\u7a4d\u5b9f\u65bd\u3001\u4f4f\u6c11\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u306e\u30e9\u30f3\u30c0\u30e0\u30fb\u30b5\u30f3\u30d7\u30ea\u30f3\u30b0\u3001\u3042\u308b\u3044\u306f\u65e5\u672c\u4eba\u3067\u591a\u3044\u3001\u30d4\u30ed\u30ea\u83cc\u306e\u5f71\u97ff\u3092\u691c\u8a0e\u3001\u3044\u304f\u3064\u304b\u306e\u30d0\u30a4\u30a2\u30b9\u3092\u6392\u9664\u3057\u3088\u3046\u3068\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u3067\u3059\u3002<\/p>\n

\u5f53\u7136\u306a\u304c\u3089\u3001\u82f1\u6587\u8ad6\u6587\u3068\u3057\u3066\u3082\u767a\u8868\u3055\u308c\u3066\u3044\u307e\u3059\u3002\uff08\u8457\u8005\u30ea\u30b9\u30c8\u3092\u307f\u308b\u3068\u3001\u6d77\u5916\u30b9\u30bf\u30c3\u30d5\u304c\u53c2\u52a0\u3057\u3066\u3044\u307e\u3059\uff09\u3002
\nSakamoto C, et al.
\nCase-control study on the association of upper gastrointestinal bleeding and nonsteroidal anti-inflammatory drugs in Japan.Eur J Clin Pharmacol. 2006 Sep;62(9):765-72. Epub 2006 Jul 4. <\/b>PMID: 16821007<\/p>\n

<\/p>\n

\u25a0\u7814\u7a76\u7d44\u7e54\uff1a\u3000NSAID\uff53\u6f70\u760d\u75ab\u5b66\u7814\u7a76\u73ed\u304c\u3053\u306e\u7814\u7a76\u306e\u305f\u3081\u306b\u7d44\u7e54\u3055\u308c\u305f\u3002\u904b\u55b6\u59d4\u54e1\u9577\uff1a\u5bfa\u91ce\u5f70\u3001\u53c2\u52a0\u65bd\u8a2d14\u75c5\u9662\u3002<\/p>\n

\u25a0\u30b1\u30fc\u30b9\uff11\u306b\u5bfe\u3057\u3066\u3001\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\uff12\u3068\u3057\u3066\u8abf\u67fb\u3057\u305f\u3002<\/p>\n

=============================================================
\n\u2605\u2605\u672c\u8a18\u4e8b\u3067\u7d39\u4ecb\u3057\u305f\u3044\u70b9\u306f\u4ee5\u4e0b\u306e\u90e8\u5206\u3067\u3059\u3002<\/p>\n

<\/p>\n


\n(1)\u30c7\u30fc\u30bf\u7ba1\u7406\u306a\u3069\u306e\u305f\u3081\u306b\u3001\uff11\u65bd\u8a2d\u3067\u7814\u7a76\u9078\u4efb\u306e\u30b3\u30fc\u30c7\u30a4\u30cd\u30fc\u30bf\u30fc1\u540d\u304c\u9014\u4e2d\u3067\u63a1\u7528\u3055\u308c\u305f\u3002
\n(2)\u30d1\u30a4\u30ed\u30c3\u30c8\u7814\u7a76\u3067\u7814\u7a76\u306e\u30b5\u30a4\u30ba\u3084\u671f\u9593\u306e\u898b\u901a\u3057\u304c\u3067\u304d\u305f\u3002
\n(3)\u7814\u7a76\u306e\u9042\u884c\u306b\u306f\u3001\u5404\u65bd\u8a2d\u3067\u5b9f\u65bd\u53ef\u80fd\u306a\u4f53\u6027\u3092\u4f5c\u308b\u4ed6\u306b\u3001\u7d71\u62ec\u904b\u55b6\u59d4\u54e1\u4f1a\u3001\u30b1\u30fc\u30b9\u306e\u59a5\u5f53\u6027\u306b\u95a2\u3059\u308b\u72ec\u7acb\u8a55\u4fa1\u59d4\u54e1\u4f1a\u3001\u3055\u3089\u306b\u7814\u7a76\u4e8b\u52d9\u5c40\u306e\uff13\u3064\u306e\u5b58\u5728\u304c\u91cd\u8981\u3002<\/b><\/p>\n

<\/p>\n

\u3084\u306f\u308a\u7814\u7a76\u3068\u306f\u3044\u304b\u306b\u5927\u5909\u306a\u3082\u306e\u3067\u3042\u308b\u3053\u3068\u304c\u3088\u304f\u308f\u304b\u308a\u307e\u3059\u304c\u3001\u3053\u306e\u3088\u3046\u306a\u8cea\u306e\u9ad8\u3044\u7814\u7a76\u304c\u56fd\u5185\u3067\u3082\u591a\u6570\u767b\u5834\u3057\u3066\u307b\u3057\u3044\u3082\u306e\u3067\u3059\u3002
\n\u307e\u305f\u3001\u3053\u306e\u3088\u3046\u306a\u89b3\u5bdf\u7814\u7a76\u304c\u8907\u6570\u3042\u3063\u3066\u985e\u4f3c\u306e\u6210\u7e3e\u306a\u3089\u3001GRADE\u30b7\u30b9\u30c6\u30e0\u3067\u5224\u5b9a\u3059\u308b\u3068\u3001low\u2192high quality<\/b>\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u3068\u3044\u3046\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002\uff08\u5f37\u3044\u95a2\u9023\u6027\u304b\u3089\uff09<\/p>\n

<\/p>\n

\u3064\u307e\u308a\u3001\u4f55\u3089\u304b\u306e\u6b20\u70b9\u304c\u3042\u308b\u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a13\uff08\u3053\u306e\u5834\u5408\u3001high \u2192moderate <\/b>\uff09\u3092\u51cc\u3050\u30a8\u30d3\u30c7\u30f3\u30b9\u30ec\u30d9\u30eb\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

GRADE\u3067\u306f\u3001\u63a8\u5968\u5ea6\u3068\u3001\u30a8\u30d3\u30c7\u30f3\u30b9\u306e\u8cea\u3092\u5206\u96e2\u3057\u3066\u3044\u307e\u3059\u3002\u3000\u3059\u306a\u308f\u3061\u3001\u3044\u304b\u306b\u3059\u3050\u308c\u305f\u3000\u201dRCT\u304c\u591a\u6570\u201d\u3067\u3082\u3001\u201d\u5f37\u3044\u63a8\u5968\u201d\u306b\u306f\u3000\u306a\u3089\u306a\u3044\u5834\u5408\u3082\u3042\u308a\u3001\u30a8\u30d3\u30c7\u30f3\u30b9\u30ec\u30d9\u30eb\u306e\u968e\u5c64\u7684\u306b\u306f\u4e0b\u4f4d\u3068\u5224\u65ad\u3055\u308c\u3066\u3044\u305f\u75c7\u4f8b\u5bfe\u7167\u7814\u7a76\u306a\u3069\u306e\u89b3\u5bdf\u7814\u7a76 […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[5],"tags":[49,102],"_links":{"self":[{"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/posts\/79"}],"collection":[{"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=79"}],"version-history":[{"count":1,"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/posts\/79\/revisions"}],"predecessor-version":[{"id":603,"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/posts\/79\/revisions\/603"}],"wp:attachment":[{"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=79"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=79"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=79"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}