{"id":9328,"date":"2019-03-18T14:46:40","date_gmt":"2019-03-18T05:46:40","guid":{"rendered":"http:\/\/aihara.la.coocan.jp\/?p=9328"},"modified":"2019-03-19T08:33:47","modified_gmt":"2019-03-18T23:33:47","slug":"%e3%83%94%e3%83%ad%e3%83%aa%e8%8f%8c%e9%99%a4%e8%8f%8c%ef%bc%9d%e8%83%83%e3%81%8c%e3%82%93%e7%99%ba%e7%94%9f%e3%82%bc%e3%83%ad%e3%81%a7%e3%81%af%e3%81%aa%e3%81%84","status":"publish","type":"post","link":"http:\/\/aihara.la.coocan.jp\/?p=9328","title":{"rendered":"\u30d4\u30ed\u30ea\u83cc\u9664\u83cc\uff1d\u80c3\u304c\u3093\u767a\u751f\u30bc\u30ed\u3067\u306f\u306a\u3044"},"content":{"rendered":"

\u30d4\u30ed\u30ea\u83cc\u306e\u9664\u83cc\u306b\u3088\u3063\u3066\u80c3\u304c\u3093\u767a\u751f\u3092\u64b2\u6ec5\u3067\u304d\u308b\u3068\u601d\u3063\u3066\u3044\u308b\u4eba\u3082\u3044\u308b\u3088\u3046\u306a\u306e\u3067\u3001National Cancer Institute\u306e\u516c\u958b\u60c5\u5831\u3092\u7ffb\u8a33\u3057\u3066\u7d39\u4ecb\u3057\u307e\u3059\u3002<\/p>\n

Helicobacter pylori and Cancer<\/b><\/a><\/p>\n

\n<\/p>\n

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<\/p>\n

\n

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\u30d4\u30ed\u30ea\u83cc\u611f\u67d3\u3068\u975e\u5674\u9580\u90e8\u80c3\u304c\u3093\u306e\u30ea\u30b9\u30af\u3068\u306e\u95a2\u9023\u6027\u306b\u3064\u3044\u3066\u306e\u8ffd\u52a0\u7684\u30a8\u30d3\u30c7\u30f3\u30b9\u306f\u3001\u30d5\u30a3\u30f3\u30e9\u30f3\u30c9\u306b\u304a\u3051\u308bAlpha-Tocopherol, Beta-Carotene (ATBC) Cancer Prevention Study\u306e\u3088\u3046\u306a\u524d\u5411\u304d\u30b3\u30db\u30fc\u30c8\u7814\u7a76\u304b\u3089\u5f97\u3089\u308c\u3066\u3044\u308b\uff0813\uff09\u3002\u975e\u5674\u9580\u90e8\u80c3\u304c\u3093\uff08\u767a\u75c7\u8005\u3092\u975e\u304c\u3093\u306e\u5bfe\u7167\u88ab\u9a13\u8005\u3068\u6bd4\u8f03\u3059\u308b\u3068\u3001\u30d4\u30ed\u30ea\u83cc\u611f\u67d3\u8005\u306f\u975e\u5674\u9580\u90e8\u80c3\u304c\u3093\u30ea\u30b9\u30af\u304c\u7d048\u500d\u5897\u52a0\u3057\u305f\u3053\u3068\u304c\u7814\u7a76\u8005\u3089\u306b\u3088\u3063\u3066\u767a\u898b\u3055\u308c\u305f\uff0814\uff09\u3002<\/p>\n

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\n

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\n

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\n

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\u30d4\u30ed\u30ea\u83cc\u306e\u4e2d\u306b\u306f\u3001\u7d30\u80de\u6bd2\u7d20\u95a2\u9023\u907a\u4f1d\u5b50A\uff08cytotoxin-associated gene A\uff1acagA\uff09\u3068\u547c\u3070\u308c\u308b\u907a\u4f1d\u5b50\u306b\u3088\u3063\u3066\u7523\u751f\u3055\u308c\u308b\u6bd2\u7d20\u3092\u80c3\u306e\u7c98\u819c\u7d30\u80de\u304c\u4ea4\u308f\u308b\u63a5\u5408\u90e8\u306b\u6ce8\u5165\u3059\u308b\u305f\u3081\u306b\u91dd\u72b6\u306e\u4ed8\u5c5e\u7269\u3092\u4f7f\u7528\u3059\u308b\u3082\u306e\u3082\u3042\u308b\uff0821\u300122\uff09\u3002\u3053\u306e\u6bd2\u7d20\uff08CagA\u3068\u3057\u3066\u77e5\u3089\u308c\u3066\u3044\u308b\uff09\u306f\u80c3\u306e\u7d30\u80de\u69cb\u9020\u3092\u5909\u3048\u3001\u30d4\u30ed\u30ea\u83cc\u304c\u3088\u308a\u7c21\u5358\u306b\u305d\u308c\u3089\u306b\u4ed8\u7740\u3059\u308b\u306e\u3092\u53ef\u80fd\u306b\u3059\u308b\u3002\u6bd2\u7d20\u3078\u306e\u9577\u671f\u66dd\u9732\u306f\u6162\u6027\u708e\u75c7\u3092\u5f15\u304d\u8d77\u3053\u3059\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u30d4\u30ed\u30ea\u83cc\u306e\u3059\u3079\u3066\u306e\u83cc\u682a\u304ccagA\u907a\u4f1d\u5b50\u3092\u4fdd\u6709\u3059\u308b\u308f\u3051\u3067\u306f\u306a\u3044\u3002\u4fdd\u6709\u3057\u3066\u3044\u308b\u3082\u306e\u306fcagA\u967d\u6027\u3068\u3057\u3066\u5206\u985e\u3055\u308c\u308b\u3002<\/p>\n

\u75ab\u5b66\u7684\u30a8\u30d3\u30c7\u30f3\u30b9\u306f\u3001\uff43\uff41\uff47\uff21\u967d\u6027\u682a\u306b\u3088\u308b\u611f\u67d3\u304c\u3001\u975e\u5674\u9580\u90e8\u80c3\u304c\u3093\u306e\u30ea\u30b9\u30af\u5897\u52a0\u3001\u306a\u3089\u3073\u306b\u80c3\u5674\u9580\u90e8\u304c\u3093\u3068\u98df\u9053\u817a\u304c\u3093\u306e\u30ea\u30b9\u30af\u6e1b\u5c11\u3068\u7279\u306b\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u308b\u3002\u4f8b\u3048\u3070\u3001\u4e16\u754c\u4e2d\u3067\u5b9f\u65bd\u3055\u308c\u305f16\u4ef6\u306e\u75c7\u4f8b\u5bfe\u7167\u7814\u7a76\u306e\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u306f\u3001cagA\u967d\u6027\u30d4\u30ed\u30ea\u83cc\u306e\u611f\u67d3\u8005\u306f\u3001cagA\u9670\u6027\u30d4\u30ed\u30ea\u83cc\u306e\u611f\u67d3\u8005\u306e2\u500d\u306e\u975e\u5674\u9580\u90e8\u80c3\u304c\u3093\u306e\u30ea\u30b9\u30af\u304c\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u305f\u3002\u9006\u306b\u3001\u30b9\u30a6\u30a7\u30fc\u30c7\u30f3\u3067\u5b9f\u65bd\u3055\u308c\u305f\u75c7\u4f8b\u5bfe\u7167\u7814\u7a76\u3067\u306f\u3001cagA\u967d\u6027\u306e\u30d4\u30ed\u30ea\u83cc\u8005\u306f\u98df\u9053\u817a\u304c\u3093\u306e\u30ea\u30b9\u30af\u304c\u7d71\u8a08\u7684\u306b\u6709\u610f\u306b\u4f4e\u4e0b\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u305f\uff0816\uff09\u3002\u540c\u69d8\u306b\u3001\u7c73\u56fd\u3067\u5b9f\u65bd\u3055\u308c\u305f\u5225\u306e\u75c7\u4f8b\u5bfe\u7167\u7814\u7a76\u3067\u306f\u3001cagA\u967d\u6027\u30d4\u30ed\u30ea\u83cc\u611f\u67d3\u306f\u98df\u9053\u817a\u304c\u3093\u3068\u80c3\u5674\u9580\u304c\u3093\u306e\u30ea\u30b9\u30af\u6e1b\u5c11\u3068\u95a2\u9023\u3057\u3066\u3044\u305f\u304c\u3001cagA\u9670\u6027\u682a\u306e\u611f\u67d3\u306f\u30ea\u30b9\u30af\u3068\u95a2\u9023\u3057\u3066\u3044\u306a\u304b\u3063\u305f\uff0824\uff09\u3002<\/p>\n

\u6700\u8fd1\u306e\u7814\u7a76\u306f\u3001CagA\u304c\u80c3\u306e\u767a\u304c\u3093\u306b\u5bc4\u4e0e\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u793a\u5506\u3057\u3066\u3044\u308b\u3002 3\u4ef6\u306e\u7814\u7a76\u3067\u3001CagA\u967d\u6027\u30d4\u30ed\u30ea\u83cc\u611f\u67d3\u306fp53\u3092\u542b\u3080\u816b\u760d\u6291\u5236\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u4e0d\u6d3b\u6027\u5316\u3068\u95a2\u9023\u3057\u3066\u3044\u305f\uff0825-27\uff09\u3002<\/p>\n

<\/p>\n

\n

\u80c3\u7c98\u819c\u95a2\u9023\u30ea\u30f3\u30d1\u7d44\u7e54\uff08MALT\uff09\u30ea\u30f3\u30d1\u816b\u3068\u306f\u4f55\u304b\u3002\u307e\u305f\u3001\u305d\u308c\u304c\u30d4\u30ed\u30ea\u83cc\u611f\u67d3\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u3044\u3046\u30a8\u30d3\u30c7\u30f3\u30b9\u306f\u4f55\u304b<\/b><\/span><\/p>\n<\/div>\n

\u80c3MALT\u30ea\u30f3\u30d1\u816b\u306f\u307e\u308c\u306a\u7a2e\u985e\u306e\u975e\u30db\u30b8\u30ad\u30f3\u30ea\u30f3\u30d1\u816b\u3067\u3001\u80c3\u306e\u5185\u5074\u306b\u3042\u308b\u514d\u75ab\u7d30\u80de\u306e\u4e00\u7a2e\u3067\u3042\u308bB\u30ea\u30f3\u30d1\u7403\u304c\u3086\u3063\u304f\u308a\u3068\u5897\u6b96\u3059\u308b\u3053\u3068\u3092\u7279\u5fb4\u3068\u3057\u3066\u3044\u308b\u3002\u3053\u306e\u304c\u3093\u306f\u3001\u7537\u6027\u3067\u767a\u751f\u3059\u308b\u7bc0\u5916\uff08\u30ea\u30f3\u30d1\u7bc0\u5916\uff09\u306e\u975e\u30db\u30b8\u30ad\u30f3\u30ea\u30f3\u30d1\u816b\u306e\u7d0412\uff05\u3001\u5973\u6027\u3067\u767a\u751f\u3059\u308b\u7bc0\u5916\u975e\u30db\u30b8\u30ad\u30f3\u30ea\u30f3\u30d1\u816b\u306e\u7d0418\uff05\u3092\u5360\u3081\u308b\uff0828\uff09\u3002 1999-2003\u5e74\u306e\u671f\u9593\u4e2d\u3001\u7c73\u56fd\u306b\u304a\u3051\u308b\u80c3MALT\u30ea\u30f3\u30d1\u816b\u306e\u5e74\u9593\u767a\u751f\u7387\u306f\u3001\u4eba\u53e310\u4e07\u4eba\u3042\u305f\u308a\u7d041\u4ef6\u3067\u3042\u3063\u305f\u3002<\/p>\n

\u901a\u5e38\u3001\u80c3\u306e\u5185\u5c64\u306f\u30ea\u30f3\u30d1\u7cfb\uff08\u514d\u75ab\u7cfb\uff09\u7d44\u7e54\u3092\u6b20\u3044\u3066\u3044\u308b\u304c\u3001\u3053\u306e\u7d44\u7e54\u306e\u767a\u9054\u306f\u3057\u3070\u3057\u3070\u30d4\u30ed\u30ea\u83cc\u306b\u3088\u308b\u5185\u5c64\u306e\u30b3\u30ed\u30cb\u30fc\u5f62\u6210\u306b\u53cd\u5fdc\u3057\u3066\u523a\u6fc0\u3055\u308c\u308b\uff082\uff09\u3002\u307e\u308c\u306a\u5834\u5408\u306b\u306e\u307f\u3001\u3053\u306e\u7d44\u7e54\u306fMALT\u30ea\u30f3\u30d1\u816b\u3092\u5f15\u304d\u8d77\u3053\u3059\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u80c3MALT\u30ea\u30f3\u30d1\u816b\u306e\u307b\u307c\u3059\u3079\u3066\u306e\u60a3\u8005\u304c\u30d4\u30ed\u30ea\u83cc\u611f\u67d3\u306e\u5fb4\u5019\u3092\u793a\u3057\u3001\u3053\u306e\u816b\u760d\u3092\u767a\u75c7\u3059\u308b\u30ea\u30b9\u30af\u306f\u975e\u611f\u67d3\u8005\u3088\u308a\u3082\u611f\u67d3\u8005\u304c6\u500d\u4ee5\u4e0a\u9ad8\u3044\uff0829\u300130\uff09\u3002<\/p>\n

<\/p>\n

\n

\u30d4\u30ed\u30ea\u83cc\u611f\u67d3\u306f\u4ed6\u306e\u304c\u3093\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u304b<\/b><\/span><\/p>\n<\/div>\n

\u30d4\u30ed\u30ea\u83cc\u611f\u67d3\u304c\u4ed6\u306e\u304c\u3093\u306e\u30ea\u30b9\u30af\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u304b\u3069\u3046\u304b\u306f\u4e0d\u660e\u3067\u3042\u308b\u3002 \u3044\u304f\u3064\u304b\u306e\u7814\u7a76\u3067\u306f\u30d4\u30ed\u30ea\u83cc\u611f\u67d3\u3068\u81b5\u81d3\u304c\u3093\u306e\u9593\u306e\u95a2\u9023\u306e\u53ef\u80fd\u6027\u304c\u767a\u898b\u3055\u308c\u305f\u304c\u3001\u305d\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u306f\u76f8\u53cd\u3057\u3066\u3044\u308b\uff0831\u300132\uff09\u3002 \u30d4\u30ed\u30ea\u83cc\u304c\u7d50\u8178\u76f4\u8178\u817a\u304c\u3093\uff0833\uff09\u307e\u305f\u306f\u80ba\u304c\u3093\uff0832\u300134\uff09\u306e\u5371\u967a\u56e0\u5b50\u3067\u3042\u308b\u53ef\u80fd\u6027\u3092\u8abf\u67fb\u3057\u305f\u7814\u7a76\u3067\u306f\u3001\u305d\u308c\u304c\u3044\u305a\u308c\u304b\u306e\u304c\u3093\u306e\u30ea\u30b9\u30af\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3068\u3044\u3046\u30a8\u30d3\u30c7\u30f3\u30b9\u306f\u898b\u51fa\u3055\u308c\u3066\u3044\u306a\u3044\u3002<\/p>\n

<\/p>\n

\n

\u30d4\u30ed\u30ea\u83cc\u611f\u67d3\u3092\u6839\u7d76\u3059\u308b\u305f\u3081\u306e\u6cbb\u7642\u306f\u80c3\u304c\u3093\u306e\u767a\u751f\u7387\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u304b<\/b><\/span><\/p>\n<\/div>\n

\u80c3\u304c\u3093\u306e\u767a\u751f\u7387\u304c\u975e\u5e38\u306b\u9ad8\u3044\u5730\u57df\u3067\u3042\u308b\u4e2d\u56fd\u306e\u5c71\u6771\u7701\u3067\u5b9f\u65bd\u3055\u308c\u305f\u30e9\u30f3\u30c0\u30e0\u5316\u81e8\u5e8a\u8a66\u9a13\u304b\u3089\u306e\u30c7\u30fc\u30bf\u306e\u9577\u671f\u8ffd\u8de1\u8abf\u67fb\u306b\u3088\u308a\u3001\u30d4\u30ed\u30ea\u83cc\u3092\u6839\u7d76\u3059\u308b\u305f\u3081\u306e\u6297\u83cc\u85ac\u306b\u3088\u308b\u77ed\u671f\u9593\u306e\u6cbb\u7642\u306f\u80c3\u304c\u3093\u306e\u767a\u751f\u7387\u3092\u6e1b\u5c11\u3055\u305b\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u305f\u3002 \u6cbb\u7642\u5f8c15\u5e74\u8fd1\u304f\u306e\u9593\u306b\u3001\u80c3\u304c\u3093\u306e\u767a\u751f\u7387\u306f\u307b\u307c40%\u6e1b\u5c11\u3057\u305f\uff0835\uff09\u3002 \u3053\u306e\u8a66\u9a13\u306e\u7d50\u679c\u304c\u30d4\u30ed\u30ea\u83cc\u3092\u6839\u7d76\u3059\u308b\u305f\u3081\u306e\u6297\u83cc\u6cbb\u7642\u306e\u80c3\u304c\u3093\u767a\u751f\u7387\u3078\u306e\u5f71\u97ff\u3092\u691c\u8a0e\u3057\u3066\u3044\u308b\u3044\u304f\u3064\u304b\u306e\u5c0f\u898f\u6a21\u8a66\u9a13\u306e\u7d50\u679c\u3068\u7d71\u5408\u3055\u308c\u308b\u3068\u3001\u540c\u69d8\u306e\u6e1b\u5c11\u304c\u898b\u3089\u308c\u305f\uff0835\uff09\u3002<\/p>\n

\n

\uff08\u6ce8\uff1a\u76f8\u539f\u8ffd\u52a0\uff09:
\n\u4e0a\u8a18ref-35\u3088\u308a<\/p>\n<\/div>\n

\"\"<\/a>
\n<\/p>\n

\n

\uff08\u6ce8\uff1a\u76f8\u539f\u8ffd\u52a0\uff09:
\nHP\u9664\u83cc\u6cbb\u7642\u306f\u3001\u80c3\u304c\u3093\u3084\u98df\u9053\u304c\u3093\u306b\u3088\u308b\u6b7b\u4ea1\u3092\u7d71\u8a08\u7684\u306b\u6709\u610f\u306b\u6e1b\u5c11\u3055\u305b\u306a\u304b\u3063\u305f\u3002<\/p>\n<\/div>\n

\"\"<\/a><\/p>\n

<\/p>\n

\n

\u30d4\u30ed\u30ea\u83cc\u611f\u67d3\u306e\u8a3a\u65ad\u3068\u6cbb\u7642\u304c\u5fc5\u8981\u306a\u306e\u306f\u8ab0\u304b<\/b><\/span><\/p>\n<\/div>\n

\u75be\u75c5\u7ba1\u7406\u4e88\u9632\u30bb\u30f3\u30bf\u30fc\uff08Centers for Disease Control and Prevention\uff1aCDC\uff09\u306b\u3088\u308b\u3068\u3001\u6d3b\u52d5\u7684\u306a\u80c3\u6f70\u760d\u3084\u5341\u4e8c\u6307\u8178\u6f70\u760d\u3001\u307e\u305f\u306f\u6f70\u760d\u65e2\u5f80\u6b74\u3092\u6709\u3059\u308b\u4eba\u306f\u3001\u30d4\u30ed\u30ea\u83cc\u306e\u691c\u67fb\u3092\u53d7\u3051\u3001\u611f\u67d3\u3057\u3066\u3044\u308b\u5834\u5408\u306f\u6cbb\u7642\u3092\u53d7\u3051\u308b\u3079\u304d\u3067\u3042\u308b\uff08\u3088\u308a\u8a73\u3057\u3044\u60c5\u5831\u306fCDC\u304b\u3089\u5165\u624b\u53ef\u80fd*\uff09\u3002\u30d4\u30ed\u30ea\u83cc\u611f\u67d3\u75c7\u306e\u691c\u67fb\u3068\u6cbb\u7642\u306f\u3001\u65e9\u671f\u80c3\u304c\u3093\u306e\u5207\u9664\u5f8c\u3084\u4f4e\u60aa\u6027\u5ea6\u306e\u80c3MALT\u30ea\u30f3\u30d1\u816b\u306b\u3082\u63a8\u5968\u3055\u308c\u308b\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u307b\u3068\u3093\u3069\u306e\u5c02\u9580\u5bb6\u306f\u3001\u5165\u624b\u53ef\u80fd\u306a\u30a8\u30d3\u30c7\u30f3\u30b9\u304c\u30d4\u30ed\u30ea\u83cc\u611f\u67d3\u306e\u5e83\u7bc4\u306a\u691c\u67fb\u3084\u6839\u7d76\u3092\u652f\u6301\u3057\u3066\u3044\u306a\u3044\u3053\u3068\u306b\u540c\u610f\u3057\u3066\u3044\u308b\uff0836\uff09\u3002<\/p>\n

\n

\uff08\u6ce8\uff1a\u76f8\u539f\u8ffd\u52a0\uff09:
\n*:\u4f8b\u3001Treatment recommendations for children have not been formulated.\u3002<\/p>\n<\/div>\n

\n<\/p>\n

\n

\u53c2\u8003\u6587\u732e<\/b><\/span><\/p>\n<\/div>\n

    \n
  1. Atherton JC. The pathogenesis of Helicobacter pylori-induced gastro-duodenal diseases. Annual Review of Pathology<\/i> 2006; 1:63–96.  [PubMed Abstract]<\/a><\/li>\n
  2. Kusters JG, van Vliet AH, Kuipers EJ. Pathogenesis of Helicobacter pylori infection. Clinical Microbiology Reviews<\/em> 2006; 19(3):449–490.  [PubMed Abstract]<\/a><\/li>\n
  3. Ferlay J, Shin HR, Bray F, et al. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. International Journal of Cancer<\/i> 2010; 127(12):2893–2917.  [PubMed Abstract]<\/a><\/li>\n
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