{"id":9413,"date":"2019-04-10T10:05:02","date_gmt":"2019-04-10T01:05:02","guid":{"rendered":"http:\/\/aihara.la.coocan.jp\/?p=9413"},"modified":"2019-04-10T10:05:02","modified_gmt":"2019-04-10T01:05:02","slug":"%e3%83%a1%e3%82%bf%e3%82%a2%e3%83%8a%e3%83%aa%e3%82%b7%e3%82%b9%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e8%a9%a6%e9%a8%93%e9%80%90%e6%ac%a1%e8%a7%a3%e6%9e%90%ef%bc%88tsa%ef%bc%89","status":"publish","type":"post","link":"http:\/\/aihara.la.coocan.jp\/?p=9413","title":{"rendered":"\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u306b\u304a\u3051\u308b\u8a66\u9a13\u9010\u6b21\u89e3\u6790\uff08TSA\uff09"},"content":{"rendered":"

\u8fd1\u5e74\u307e\u3059\u307e\u3059\u5897\u52a0\u3057\u3066\u3044\u308b\u8a66\u9a13\u9010\u6b21\u89e3\u6790\uff08Trial Sequential Analysis: TSA\uff09<\/b>\u306b\u95a2\u3059\u308b\u8ad6\u6587\u306e\u3072\u3068\u3064\u3067\u3059\u3002<\/p>\n

Increased Risks for Random Errors are Common in Outcomes Graded as High Certainty of Evidence. J Clin Epidemiol. 2019 Feb;106:50-59.<\/a> <\/p>\n

\u4e00\u90e8\u3092\u7701\u7565\u3057\u305f\u6284\u9332\u3067\u3059\u3002<\/p>\n

\u76ee\u7684:<\/b>\u30a8\u30d3\u30c7\u30f3\u30b9\u306e\u78ba\u5b9f\u6027\uff08CoE\uff09\u304c\u201d\u9ad8\u201d\u3068\u3057\u3066\u8a55\u4fa1\u3055\u308c\u305f\u30a2\u30a6\u30c8\u30ab\u30e0\u306b\u304a\u3051\u308b\u30e9\u30f3\u30c0\u30e0\u8aa4\u5dee\u306e\u30ea\u30b9\u30af\u3092\u8a55\u4fa1\u3059\u308b\u3002
\nGRADE (Grading of Recommendations Assessment, Development, and Evaluation)\u3092\u4f7f\u3063\u3066\u9ad8\u3044CoE\u3068\u7b49\u7d1a\u4ed8\u3051\u3055\u308c\u305f2\u5024\u30a2\u30a6\u30c8\u30ab\u30e0\u306eCochrane\u30ec\u30d3\u30e5\u30fc\u3092\u30e9\u30f3\u30c0\u30e0\u306b100\u4ef6\u9078\u629e\u3057\u305f\u3002\u30e9\u30f3\u30c0\u30e0\u8aa4\u5dee\u306e\u30ea\u30b9\u30af\u5897\u52a0\u3092\u691c\u51fa\u3059\u308b\u305f\u3081\u306b\u3001\u30bf\u30a4\u30d7I\uff08\u03b1= 0.05\uff09\u3068\u30bf\u30a4\u30d7II\uff08\u03b2= 0.10\uff09\u306e\u8aa4\u5dee\u306b\u5bfe\u3057\u3066\u5f93\u6765\u306e\u95be\u5024\u3092\u7528\u3044\u305f\u8a66\u9a13\u9010\u6b21\u89e3\u6790\uff08Trial Sequential Analysis: TSA\uff09\u3092\u5b9f\u65bd\u3057\u305f\u3002<\/p>\n

\u7d50\u679c\uff1a<\/b>\u5168\u4f53\u7684\u306b\u3001\u9ad8\u3044CoE\u3068\u7b49\u7d1a\u4ed8\u3051\u3055\u308c\u305f\u30a2\u30a6\u30c8\u30ab\u30e0\u306e38\uff05\uff0895\uff05\u4fe1\u983c\u533a\u9593\uff1a28\uff05\uff5e47\uff05\uff09\u3067\u30e9\u30f3\u30c0\u30e0\u8aa4\u5dee\u306e\u30ea\u30b9\u30af\u5897\u52a0\u304c\u3042\u3063\u305f\u3002\u5bb3\u3092\u8a55\u4fa1\u3057\u305f\u30a2\u30a6\u30c8\u30ab\u30e0\u306f\u3001\u5229\u76ca\u3092\u8a55\u4fa1\u3057\u305f\u30a2\u30a6\u30c8\u30ab\u30e0\u3088\u308a\u3082\u983b\u7e41\u306b\u5f71\u97ff\u3092\u53d7\u3051\u305f\uff0847\uff05\u5bfe12\uff05\uff09\u3002\u30e9\u30f3\u30c0\u30e0\u8aa4\u5dee\u306e\u5897\u52a0\u306b\u3088\u308b\u30a2\u30a6\u30c8\u30ab\u30e0\u3092\u518d\u30b0\u30ec\u30fc\u30c9\u4ed8\u3051\u3059\u308b\u3068\u3001\u73fe\u5728\u306e\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306b\u304a\u3044\u306674\uff05\u304c\u30b0\u30ec\u30fc\u30c9\u30c0\u30a6\u30f3\u3055\u308c\u308b\u3079\u304d\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u305f\u3002<\/p>\n

\u7d50\u8ad6\uff1a<\/b>
\n\u610f\u601d\u6c7a\u5b9a\u8005\u306f\u3001\u9ad8\u3044CoE\u3068\u7b49\u7d1a\u4ed8\u3051\u3055\u308c\u305f\u30a2\u30a6\u30c8\u30ab\u30e0\u306f\u3001\u3057\u3070\u3057\u3070\u3001\u507d\u967d\u6027\u3084\u507d\u9670\u6027\u306e\u6240\u898b\u304c\u9ad8\u3044\u3053\u3068\u3092\u8a8d\u8b58\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u3002<\/p>\n

***************
\n\u30a8\u30d3\u30c7\u30f3\u30b9\u7dcf\u4f53\u306e\u78ba\u5b9f\u6027\u3092\u8a55\u4fa1\u3059\u308bGRADE\u30c9\u30e1\u30a4\u30f3\u306e\u4e00\u3064\u3067\u3042\u308bimprecision<\/b>\u306e\u8a55\u4fa1\u306b\u304a\u3044\u3066\u3001\u3053\u306eTSA\u304c\u975e\u5e38\u306b\u91cd\u8981\u3067\u3042\u308a\u3001\u4eca\u5f8c\u306f\u30eb\u30fc\u30c1\u30f3\u5316\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u3055\u3089\u306b\u306fGDT\u306b\u63a1\u7528\u3055\u3048\u308b\u53ef\u80fd\u6027\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\n

\u4f8b\uff11\uff0eTSA\u306e\uff14\u3064\u306e\u30b7\u30ca\u30ea\u30aa\u306e\u6982\u7565\u56f3<\/b>
\n\"\"<\/a>
\n
\n[\u5224\u65ad]
\nA: Z=1.96\u3068\u4ea4\u5dee\u3057\u3066\u304a\u308a\u6709\u610f\u306a\u7d50\u679c\u3067\u3042\u308b\u304c\u3001Z\u66f2\u7dda\u306fmonitoring boundary\uff08\u8d64\u7ddasuperiority\uff09\u3068\u4ea4\u5dee\u3057\u3066\u3044\u306a\u3044\u306e\u3067\u3001\u8aa4\u3063\u305f\u52b9\u679c\u3067\u3042\u308b\uff08false positive<\/b>\uff09\u3002
\nB: \u60c5\u5831\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u306b\u5230\u9054\u3059\u308b\u524d\u306b\u3001Z\u66f2\u7dda\u306fmonitoring boundary\uff08\u8d64\u7ddasuperiority\uff09\u3068\u4ea4\u5dee\u3057\u3001\u78ba\u56fa\u306a\u30a8\u30d3\u30c7\u30f3\u30b9\u3067\u3042\u308b\uff08true positive <\/b>\uff09
\nC: Z=1.96\u3068\u4ea4\u5dee\u3057\u3066\u304a\u3089\u305a\u30a8\u30d3\u30c7\u30f3\u30b9\u304c\u6b20\u5982\u3057\u3066\u3044\u308b\u3002\u3059\u306a\u308f\u3061\u3001\u3053\u306e\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u306f\u5fc5\u8981\u60c5\u5831\u91cf\u3088\u308a\u5c11\u306a\u3044\u60a3\u8005\u3092\u7d44\u307f\u5165\u308c\u3066\u3044\u308b\uff08false negative<\/b>\uff09\u3002
\nD: \u5fc5\u8981\u60c5\u5831\u91cf\u306b\u306f\u5230\u9054\u3057\u3066\u3044\u308b\u304c\u3001Z\u66f2\u7dda\u306fmonitoring boundary\uff08\u8d64\u7ddanon-superiority, futility\uff09\u3068\u4ea4\u5dee\u3057\u3066\u304a\u308a\u3001\u4ecb\u5165\u52b9\u679c\u306f\u306a\u3044\uff08true negative<\/b>\uff09\u3002<\/p>\n

 
\n\u4f8b\uff12\uff0eTSA user manual\u3088\u308a<\/b>
\n\"\"<\/a>
\n
\n[\u5224\u65ad]
\n\u7981\u7159\u306b\u3088\u308b\u52b9\u679c\u306f20%\u3092\u8d85\u3048\u306a\u3044\u3053\u3068\u309280%\u3067\u691c\u51fa\u529b\u3067\u793a\u3059futility boundaries\uff08non-superiority\uff09\u3092\u4ea4\u5dee\u3057\u3066\u3044\u308b\u3002\u3064\u307e\u308a\u3001\u78ba\u4fe1\u6027\u3068\u52b9\u679c\u30b5\u30a4\u30ba\u306e\u4eee\u5b9a\u5185\u3067\u306f\u3001\u4ecb\u5165\u52b9\u679c\u306f\u306a\u3044\uff08\u771f\u9670\u6027\uff09\u3002
\n 
\n\u4f8b3. STATA \u201dTrial sequential boundaries for cumulative meta-analyses\u201d\u306e\u8a18\u8f09\u30c7\u30fc\u30bf\u3092\u5229\u7528\u3057\u305fTSA<\/b>
\n\u30ec\u30d3\u30e5\u30fc\u306e\u76ee\u7684\u306f\u3001”One of the review\u2019s aims was to determine whether the position (high versus low) of the tip of an umbilical arterial catheter led to clinical vascular compromise.”
\n
\n\"\"<\/a>
\n
\n[\u5224\u65ad]
\n\uff15\u4ef6\u306e\u7814\u7a76\u304b\u3089\u306a\u308b\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u3067\u3042\u308b\u3002
\n\u5fc5\u8981\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u306b\u5230\u9054\u3059\u308b\u524d\u306b\u3001Z\u66f2\u7dda\u306fmonitoring boundary\uff08\u8d64\u7ddasuperiority\uff09\u3068\u4ea4\u5dee\u3057\u3001\u78ba\u56fa\u306a\u30a8\u30d3\u30c7\u30f3\u30b9\u3067\u3042\u308b\u3002<\/p>\n

\u306a\u304a\u3001TSA\u89e3\u6790\u306b\u304a\u3044\u3066\u306f\u3001
\n\u7570\u8cea\u6027\u3092\u5229\u7528\u3057\u305f\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u306b\u95a2\u3057\u3066\u3082\u3001\u5f93\u6765\u306eI2<\/sup>\u4f7f\u7528\u3067\u306f\u306a\u304f\u3001D2<\/sup> (Diversity) \u3001\u3055\u3089\u306b\u306fI2<\/sup>\u3092\u4f7f\u3063\u305fHeterogeneity-adjusted information size, D2<\/sup>\u3092\u4f7f\u3063\u305f\u3001Diversity-adjusted infromation size\u3092\u8003\u616e\u3059\u308b\u3053\u3068\u3082\u3067\u304d\u307e\u3059\u3002
\n\uff08\u8a73\u7d30\u306f\u30de\u30cb\u30e5\u30a2\u30eb\u3084\u95a2\u9023\u6587\u732e\u3092\u53c2\u7167\uff09<\/p>\n

\u8a66\u9a13\u9010\u6b21\u89e3\u6790\uff08Trial Sequential Analysis: TSA\uff09<\/b>\u306b\u95a2\u3057\u3066\u306f\u3001\u300c\u8a3a\u7642\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306e\u305f\u3081\u306eGRADE\u30b7\u30b9\u30c6\u30e0\u30003\u7248\u300d\u306ep139\u3067\u3082\u7d39\u4ecb\u3057\u3066\u3044\u307e\u3059\uff08\u66f8\u7c4d\u3067\u306fSTATA\u4f7f\u7528\u4f8b\u3092\u7d39\u4ecb\uff09\u3002<\/p>\n

\u307e\u305f\u3001TSA\u306f\u3001STATA\u30bd\u30d5\u30c8\u30a6\u30a8\u30a2\u3092\u4f7f\u3063\u3066\u5b9f\u65bd\u53ef\u80fd\u3067\u3059\u304c\u3001\u30d5\u30ea\u30fc\u306eTSA\u30bd\u30d5\u30c8\u30a6\u30a8\u30a2\uff08\u03b2\u7248\uff09<\/b>\u3067\u3082\u89e3\u6790\u53ef\u80fd\u3067\u3059\uff08\u4e0a\u8a18\u306e\u4f8b\uff13\uff09\u3002
\nhttp:\/\/www.ctu.dk\/tools-and-links\/trial-sequential-analysis.aspx<\/b><\/a><\/p>\n

\n

\n\u201dTSA was developed at The Copenhagen Trial Unit, Copenhagen, Denmark. The team consisted of Kristian Thorlund (KT), Janus Engstr\u00f8m (JE), J\u00f8rn Wetterslev (JW), Jesper Brok (JB), Georgina Imberger (GI), and Christian Gluud (CG)”\n<\/p>\n<\/div>\n

\n 
\n\u30b7\u30b9\u30c6\u30de\u30c6\u30a3\u30c3\u30af\u30ec\u30d3\u30e5\u30fc\u3084\u8a3a\u7642\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3092\u4f5c\u6210\u3059\u308b\u65b9\u3005\u306f\u3001TSA<\/b>\u3092\u6d3b\u7528\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u3068\u601d\u3044\u307e\u3059\u3002
\n
\n <\/p>\n

TSA\u3092\u4f7f\u3063\u305f\u5b9f\u969b\u306e\u8ad6\u6587\u306e\u3044\u304f\u3064\u304b\u3092\u7d39\u4ecb\u3057\u307e\u3059\u3002<\/p>\n

\n

\n\u30fbScreening for coronary artery disease in patients with type 2 diabetes: a metaanalysis and trial sequential analysis. <\/b>BMJ Open. 2017 May 9;7(5):e015089<\/a><\/p>\n

\u30fbEfficacy and safety of aspirin for primary prevention of cardiovascular events: a meta-analysis and trial sequential analysis of randomized controlled trials. <\/b>Eur Heart J. 2019 Feb 14;40(7):607-617.<\/a>\n<\/p>\n<\/div>\n

\n <\/p>\n","protected":false},"excerpt":{"rendered":"

\u8fd1\u5e74\u307e\u3059\u307e\u3059\u5897\u52a0\u3057\u3066\u3044\u308b\u8a66\u9a13\u9010\u6b21\u89e3\u6790\uff08Trial Sequential Analysis: TSA\uff09\u306b\u95a2\u3059\u308b\u8ad6\u6587\u306e\u3072\u3068\u3064\u3067\u3059\u3002 Increased Risks for Random Errors are Common i […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[5],"tags":[],"_links":{"self":[{"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/posts\/9413"}],"collection":[{"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=9413"}],"version-history":[{"count":16,"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/posts\/9413\/revisions"}],"predecessor-version":[{"id":9615,"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/posts\/9413\/revisions\/9615"}],"wp:attachment":[{"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=9413"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=9413"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/aihara.la.coocan.jp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=9413"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}