{"id":73,"date":"2008-02-04T11:12:16","date_gmt":"2008-02-04T02:12:16","guid":{"rendered":"http:\/\/aihara.la.coocan.jp\/blog\/?p=73"},"modified":"2014-04-16T15:35:10","modified_gmt":"2014-04-16T06:35:10","slug":"%e3%82%bf%e3%83%9f%e3%83%95%e3%83%abpros-and-cons-6-%ef%bc%88%e5%8b%95%e7%89%a9%e5%ae%9f%e9%a8%93%ef%bc%89","status":"publish","type":"post","link":"https:\/\/aihara.la.coocan.jp\/?p=73","title":{"rendered":"\u30bf\u30df\u30d5\u30ebpros and cons-6 \uff08\u52d5\u7269\u5b9f\u9a13\uff09"},"content":{"rendered":"<div>\n<p>\u30bf\u30df\u30d5\u30eb\u306e\u6bd2\u6027\u8a66\u9a13\u3068\u3057\u3066\u3001<b>TIP 2007; (12): 137\u3001<\/b>\u3067\u306f\u3001\u300c\u6bd2\u6027\u8a66\u9a13\u306e\u7d50\u679c\u3092\u8868\u3059\u57fa\u672c\u4e2d\u306e\u57fa\u672c\u3067\u3042\u308b\u3001\u5404\u7fa4\u306e\u52d5\u7269\u6570\uff08\u5206\u6bcd\uff09\u3082\u3001\u6b7b\u4ea1\u6570\uff08\u5206\u5b50\uff09\u3082\u8a18\u8f09\u3055\u308c\u3066\u3044\u306a\u3044\u3002\u30e1\u30fc\u30ab\u30fc\u306b\u554f\u3044\u5408\u308f\u305b\u3066\u3082\u5165\u624b\u4e0d\u53ef\u80fd\u3067\u3001\u539a\u751f\u52b4\u50cd\u7701\u3068\u30ef\u30fc\u30ad\u30f3\u30b0\u30b0\u30eb\u30fc\u30d7\u4ee5\u5916\u306b\u306f\u4e00\u5207\u60c5\u5831\u3092\u958b\u793a\u3057\u3066\u3044\u306a\u3044\u3001\u3068\u3044\u3046\u3082\u306e\u3067\u3042\u3063\u305f\u300d\u3068\u8a18\u8f09\u3055\u308c\u3001\u3055\u3089\u306b500mg\/kg\u4ee5\u4e0a\u3067\u3001\u7279\u306b7\u65e5\u9f62\u30e9\u30c3\u30c8\u3067\u306f\u3001\u5076\u767a\u7684\u3068\u306f\u3044\u3048\u306a\u3044\u6b7b\u4ea1\u304c\u751f\u3058\u3066\u3044\u305f\u3068\u3057\u3066\u3001\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u7d50\u679c(Peto)\u3092\u8a18\u8f09\u3057\u3066\u3044\u308b(\u7d71\u5408OR=14.6(6.2-34.4)\u3002\u3055\u3089\u306b\u7528\u91cf\u53cd\u5fdc\u95a2\u4fc2\uff08\u8133\u4e2d\u6fc3\u5ea6\uff09\u3082\u660e\u77ad\u3001\u3068\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><\/p>\n<p><b>\u25a0\u79c1\u306b\u306f\u3001\u4ee5\u4e0b\u306e\u70b9\u304b\u3089\u3001\u3053\u306e\u5185\u5bb9\u304c\u5168\u304f\u7406\u89e3\u3067\u304d\u306a\u3044\u3002<\/b><br \/>\n(1)\u305d\u3082\u305d\u3082\u3001\u6bd2\u6027\u8a66\u9a13\u306e\u30c7\u30fc\u30bf\u306f\u85ac\u5264\u6dfb\u4ed8\u6587\u66f8\u306b\u8a18\u8f09\u3055\u308c\u3066\u304a\u308a\u3001\u307e\u305f\u793e\u5185\u8cc7\u6599\u3082\u7c21\u5358\u306b\u5165\u624b\u53ef\u80fd\u3067\u3042\u308b\u3002<br \/>\n(2)\u6587\u66f8\u8cc7\u6599\u306b\u306f\u3001\u5206\u6bcd\u3001\u5206\u5b50\u3082\u8a18\u8f09\u3055\u308c\u3066\u3044\u308b\u3002\uff08\uff17\u9f62\u30e9\u30c3\u30c8\u3067\u306f\u3001700mg\/kg\u30672\/14\u30011000mg\/kg\u30673\/14\u30010mg\/kg\uff5e500mg\/kg\u3067\u306f\u3001\u6b7b\u4ea10\/14\u3067\u3042\u308b\u3002\u5225\u306e\u8a66\u9a13\u3067\u306f\u30011000mg\/kg\u3067\u30017\/56\u6b7b\u4ea1\u3067\u3042\u308b\u304c\u3001\u3053\u306e\u3068\u304d\u306b\u306f\u3001700mg\/kg\u3068\u306e\u6bd4\u8f03\u3067\u3042\u308b\uff09<\/p>\n<p>(3)\u6d5c\u6c0f\u304c\u6307\u6458\u3059\u308b\u3001500mg\/kg\u4ee5\u4e0a\u306e\u30c7\u30fc\u30bf\u306f\u5341\u5206\u306b\u516c\u958b\u3055\u308c\u3066\u304a\u308a\u3001\u3042\u3048\u3066\uff14\u5206\u5272\u8868\u3067\u3001\u30aa\u30c3\u30ba\u6bd4\u3092\u7b97\u51fa\u3059\u308b\u3068\uff08\u9069\u5207\u304b\u3069\u3046\u304b\u306f\u554f\u984c\uff09\u3001\uff17\u9f62\u30e9\u30c3\u30c8\u3067\u3001\u30bf\u30df\u30d5\u30eb500mg\/kg\u4ee5\u4e0a\u3068\u3001\u7121\u6295\u85ac\u7fa4\u3068\u306e\u6bd4\u8f03\uff080\/14 vs 12\/84)\u3067\u306f\u3001OR=4.3(0.24-76.5), p=0.52 \u3068\u7d71\u8a08\u5b66\u7684\u306b\u306f\u6709\u610f\u306e\u3042\u308b\u3082\u306e\u3067\u306f\u306a\u3044\u3002<br \/>\n(4)RCT\u3067\u306a\u3044\u7814\u7a76\u304b\u3089\u30c7\u30fc\u30bf\u3092\u62bd\u51fa\u3057\u3066\u3001Peto\u6cd5\u3067\u306e\u30e1\u30bf\u89e3\u6790\u3068\u306f\u597d\u307e\u3057\u3044\u3068\u306f\u3044\u3048\u306a\u3044\u3002\uff08\u6ce8\uff09<br \/>\n(5)\u6b7b\u4ea1\u3068\u3044\u3046\u30a4\u30d9\u30f3\u30c8\u3068\u3001\u85ac\u5264\u306e\u6295\u85ac\u91cf\u306b\u306f\u3001\u6fc3\u5ea6\u52fe\u914d\u53cd\u5fdc\u306f\u898b\u3089\u308c\u306a\u3044\u3002<\/p>\n<p><\/p>\n<p>\n<b>\u6ce8\uff1a<br \/>\n\u2605\u4e39\u5f8c\uff1aPeto\u306e\u65b9\u6cd5\u306f\u3001\u3042\u304f\u307e\u3067\u7121\u4f5c\u70ba\u5272\u4ed8\u306b\u57fa\u3065\u304f\u81e8\u5e8a\u8a66\u9a13\u306e\u30c7\u30fc\u30bf\u306b\u9069\u7528\u3059\u308b\u3082\u306e\u3067\u3059\u3002\u75ab\u5b66\u7814\u7a76\u306e\u30c7\u30fc\u30bf\u306b\u306f\u9069\u7528\u3059\u3079\u304d\u3067\u306f\u306a\u3044\u3068\u601d\u3044\u307e\u3059\u3002<br \/>\n\u2605\u68ee\u5be6\uff1a\u201dPeto\u6cd5\u306f\u3001RCT\u306e\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u306b\u7528\u3044\u3089\u308c\u3001\u75c7\u4f8b\u5bfe\u7167\u7814\u7a76\u3084\u3001\u30b3\u30db\u30fc\u30c8\u7814\u7a76\u306b\u7528\u3044\u3089\u308c\u308b\u3053\u3068\u306f\u7a00\u201d\u3067\u3042\u308b\u3002<\/b><\/p>\n<p><\/p>\n<p>\u3055\u3089\u306b\u3001\u8ad6\u6587\u3068\u3057\u3066\u306f\u767a\u8868\u3057\u3066\u3044\u306a\u3044\u304c\uff08\u79c1\u4fe1\u3067\uff09\u3001\u6d77\u5916\u306e\u8a66\u9a13\u3088\u308a\u3082\u3001\u56fd\u5185\u306eRCT\u304c\u4fe1\u983c\u3067\u304d\u308b\u3068\u8ff0\u3079\u3066\u3044\u308b\u304c\u3001\u3053\u308c\u3082\u9069\u5207\u3068\u306f\u601d\u3048\u307e\u305b\u3093\u3002\u306a\u305c\u306a\u3089\u3001<b>\u5b66\u4f1a\u8a8c\u306b\u767a\u8868\u3055\u308c\u305fkashiwagi \u7814\u7a76<\/b>\u306fRCT\u3067\u306f\u3042\u308b\u3082\u306e\u306e\u3001\u305d\u306e\u7d50\u679c\uff08\u30bf\u30df\u30d5\u30eb\u7fa4130\u4f8b\u3068\u3000\u30d7\u30e9\u30bb\u30dc\u7fa4122\u4f8b\u306e\u3000\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u75c7\u72b6\u306e\u4e2d\u592e\u671f\u9593\u300170 vs 93.3\u3001SE= 9.1-8.1\uff09\u304b\u3089\u3001\u5dee\u3092\u691c\u51fa\u3059\u308b\u305f\u3081\u306e\u5fc5\u8981\u30b5\u30f3\u30d7\u30eb\u6570\u306f2\u500d\u3067\u3042\u308a\u3001\u5831\u544a\u3055\u308c\u305f\u4f8b\u6570\u304b\u3089\u3001\u03b1\uff1d0.05\u3068\u3057\u3066\u3001\u691c\u51fa\u529b\uff08\uff11\uff0d\u03b2\uff09\u3092\u7b97\u51fa\u3059\u308b\u3068\u300157%\u7a0b\u5ea6\u3067\u3042\u308b\u3002(\u6ce8\uff12\uff09<br \/>\n\u3059\u306a\u308f\u3061\u3001\u3053\u306e\u5831\u544a\u3060\u3051\u3067\u306f\u3001\u75c7\u4f8b\u6570\u304c\u8db3\u308a\u306a\u3044\u3067\u3042\u308d\u3046\u3068\u3044\u3046\u3053\u3068\u3092\u610f\u5473\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><\/p>\n<p>\u307e\u305f\u3001\u539a\u751f\u52b4\u50cd\u7814\u7a76\u73ed\uff08\u75c7\u4f8b\u30b7\u30ea\u30fc\u30ba\uff09\u3068\u540c\u69d8\u306b\u3001\u7e26\u6a2a\u306e\u591a\u304f\u306e\u89e3\u6790\u3092\u884c\u306a\u3063\u3066\u3044\u307e\u3059\u304c\u3001\u7814\u7a76\u73ed\u89e3\u6790\u3068\u540c\u69d8\u306b\u3053\u308c\u3089\u306f\u3001\u7814\u7a76\u306e\u4e8b\u524d\u306b\u8a2d\u5b9a\u3055\u308c\u3066\u3044\u305f\u3082\u306e\u3067\u306f\u306a\u304f\u3001\u5168\u3066\u5f8c\u4ed8\u3051\u3067\u3059\u3002<\/p>\n<p><\/p>\n<p><b>\u691c\u5b9a\u3082\u3001\u56de\u6570\u3084\u9805\u76ee\u6570\u3092\u5897\u3084\u3059\u3068\u3001\u3069\u308c\u304b\u306f\u5dee\u304c\u3067\u3066\u304f\u308b<\/b>\u3082\u306e\u3067\u3042\u308a\u3001\u305d\u308c\u306f\u3001\u6709\u540d\u306a\u5b66\u751f\u76f8\u624b\u306e\u8b1b\u7fa9\u3067\u4f7f\u308f\u308c\u308b\u3001\u300c\u30b3\u30a4\u30f3\u6295\u3052\u300d\u3067\u3082\u7c21\u5358\u306b\u7406\u89e3\u3067\u304d\u308b\u3082\u306e\u3067\u3059\u3002<br \/>\n\u691c\u5b9a\u306f\u300110\u56de\u3082\u7e70\u308a\u8fd4\u3059\u3068\u3001 [1-(1-0.05)^ 10]= 0.401\u3001\u3059\u306a\u308f\u3061\u300140%\u306e\u78ba\u7387\u3067\u4e00\u3064\u306f\u6709\u610f\u306b\u306a\u3063\u3066\u304f\u308b\uff08\u91ce\u6751\u82f1\u6a39\uff09\u3002<\/p>\n<p><\/p>\n<p>Altman D\u306e\u7d71\u8a08\u672c\u3067\u306f\u3001\u540c\u3058\u3053\u3068\u3092\u3001\u6b21\u306e\u3088\u3046\u306b\u8a18\u8f09\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\n<b>\u533b\u5b66\u8ad6\u6587\u306e\u7d71\u8a08\u5229\u7528\u306e\u8aa4\u308a\uff1a\uff5e\uff5e\uff5e\u300011\u5909\u6570\u4ee5\u4e0a\u30925%\u6c34\u6e96\u3067\u30012\u7fa4\u6bd4\u8f03<\/b><br \/>\n\u3057\u304b\u3082\u3001\u3053\u306e\u3088\u3046\u306a\u8aa4\u308a\u306f\u300140\u5e74\u524d\u3088\u308a\u3082\u300120\u5e74\u524d\u306e\u307b\u3046\u304c\u3000\u591a\u3044\u3068\u3044\u3046\u8ad6\u6587\u3092\u7d39\u4ecb\u3057\u3066\u3044\u308b\u3002<br \/>\n<b>\u7d71\u8a08\u7684\u8981\u7d20\u3092\u8003\u616e\u3059\u308b\u6642\u671f\u306f\u3001\u7814\u7a76\u304c\u5b8c\u4e86\u3057\u305f\u3068\u304d\u3067\u306f\u306a\u304f\u3001\u7814\u7a76\u304c\u8a08\u753b\u3055\u308c\u308b\u3068\u304d\u3067\u3042\u308b\u3002(Anon)<\/b>(Altman DG: \u533b\u5b66\u7814\u7a76\u306b\u304a\u3051\u308b\u5b9f\u7528\u7d71\u8a08\u5b66\uff09\u3002<\/p>\n<p><\/p>\n<p>\uff08\u6ce8\uff12\uff09\u691c\u51fa\u529b\u306e\u8a08\u7b97\uff1a<br \/>\n<a href=\"http:\/\/biostat.mc.vanderbilt.edu\/twiki\/bin\/view\/Main\/PowerSampleSize\"><b>PS(ver2)<\/b><\/a><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u30bf\u30df\u30d5\u30eb\u306e\u6bd2\u6027\u8a66\u9a13\u3068\u3057\u3066\u3001TIP 2007; (12): 137\u3001\u3067\u306f\u3001\u300c\u6bd2\u6027\u8a66\u9a13\u306e\u7d50\u679c\u3092\u8868\u3059\u57fa\u672c\u4e2d\u306e\u57fa\u672c\u3067\u3042\u308b\u3001\u5404\u7fa4\u306e\u52d5\u7269\u6570\uff08\u5206\u6bcd\uff09\u3082\u3001\u6b7b\u4ea1\u6570\uff08\u5206\u5b50\uff09\u3082\u8a18\u8f09\u3055\u308c\u3066\u3044\u306a\u3044\u3002\u30e1\u30fc\u30ab\u30fc\u306b\u554f\u3044\u5408\u308f\u305b\u3066\u3082\u5165\u624b\u4e0d\u53ef\u80fd\u3067\u3001\u539a\u751f\u52b4\u50cd\u7701 [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[13],"tags":[95],"_links":{"self":[{"href":"https:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/posts\/73"}],"collection":[{"href":"https:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/aihara.la.coocan.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=73"}],"version-history":[{"count":1,"href":"https:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/posts\/73\/revisions"}],"predecessor-version":[{"id":609,"href":"https:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/posts\/73\/revisions\/609"}],"wp:attachment":[{"href":"https:\/\/aihara.la.coocan.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=73"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/aihara.la.coocan.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=73"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/aihara.la.coocan.jp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=73"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}