{"id":80,"date":"2008-02-28T21:27:11","date_gmt":"2008-02-28T12:27:11","guid":{"rendered":"http:\/\/aihara.la.coocan.jp\/blog\/?p=80"},"modified":"2014-04-16T15:35:09","modified_gmt":"2014-04-16T06:35:09","slug":"%e3%82%b5%e3%83%96%e3%82%b0%e3%83%ab%e3%83%bc%e3%83%97%e8%a7%a3%e6%9e%90%e3%81%a8grade%e8%a9%95%e4%be%a1","status":"publish","type":"post","link":"https:\/\/aihara.la.coocan.jp\/?p=80","title":{"rendered":"\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u89e3\u6790\u3068GRADE\u8a55\u4fa1"},"content":{"rendered":"<div>\n<p>\u6b21\u3005\u3068\u767b\u5834\u3059\u308b\u5927\u898f\u6a21\u8a66\u9a13\u3001\u591a\u65bd\u8a2d\u6bd4\u8f03\u8a66\u9a13\u306a\u3069\u306e\u591a\u7a2e\u985e\u306e\u89e3\u6790\u767a\u8868\u3092\u6211\u3005\u306f\u3069\u306e\u3088\u3046\u306b\u8a8d\u8b58\u3059\u3079\u304d\u306a\u306e\u3060\u308d\u3046\u304b\u3002<br \/>\n\u305d\u306e\u4e00\u4f8b\u3068\u3057\u3066\u3001\u6700\u8fd1\u306e\u56fd\u5185\u306e\u80ba\u764c\u6cbb\u7642\u306e\u7121\u4f5c\u70ba\u5316\u6bd4\u8f03\u8a66\u9a13\u7b2cIII\u76f8\u8a66\u9a13\u306b\u3064\u3044\u3066\u8003\u3048\u3066\u3001GRADE\u30b7\u30b9\u30c6\u30e0\u3067\u306f\u3069\u306e\u3088\u3046\u306b\u8a55\u4fa1\u3059\u308b\u306e\u304b\u3092\u7d39\u4ecb\u3057\u307e\u3059\u3002<\/p>\n<p><\/p>\n<p>\u8a66\u9a13\u306e\u6982\u7565\u306f\u3001\u65e5\u7d4cCME2008\u5e742\u6708\u306b\u8a18\u8f09\u3055\u308c\u3066\u3044\u307e\u3059\uff08\u30ef\u30fc\u30af\u30b7\u30e7\u30c3\u30d7\uff09<br \/>\n<b>\u25a0Main outcome: \u5168\u751f\u5b58\u671f\u9593\uff08OS)\u306e\u975e\u52a3\u6027\u8a66\u9a13\u3002<\/b><br \/>\n<b>\u25a0Patients\uff1a<\/b>\u8853\u5f8c\u518d\u767a\u80ba\u764c\uff08\u975e\u5c0f\u7d30\u80de\u80ba\u764cNSCLC)\u3067\u3001PS\u306f0\uff5e2\u3001\u5e74\u9f6220\u6b73\u4ee5\u4e0a\u3001\u5316\u5b66\u7642\u6cd5\u65e2\u5f80\u306e\u9032\u884c\uff0f\u8ee2\u79fb\u6027\uff08IIIB\/IV\u671f\uff09<\/p>\n<p><b>\u25a0Intervension\/Comparison:<\/b> \u30a4\u30ec\u30c3\u30b5\u7fa4245\u4f8b\u3001\u30c9\u30bb\u30bf\u30ad\u30bb\u30eb\u7fa4244\u4f8b\u30022003\u5e749\u6708\uff5e2006\u5e741\u6708\u307e\u3067\u306b490\u4f8b\u767b\u9332\u3002\u8ffd\u8de1\u671f\u9593\uff08median=21 mo)\u3002<\/p>\n<p><\/p>\n<p><b>\u7d50\u679c\uff1a<\/b><br \/>\nOS\u306e\u4e2d\u592e\u5024\u306f\u3001\u30a4\u30ec\u30c3\u30b5\u7fa4\u3067\u300111.5\u30f6\u6708\u3001\u30c9\u30bb\u30bf\u30ad\u30bb\u30eb\u7fa414\u30f6\u6708\u30011\u5e74\u751f\u5b58\u7387\u306f\u305d\u308c\u305e\u308c48%\u306854%\u3067\u3001\u4e21\u7fa4\u9593\u306b\u6709\u610f\u5dee\u306f\u306a\u304b\u3063\u305f\uff08P=0.33)\u3002\u30cf\u30b6\u30fc\u30c9\u6bd4\u306f\u30011.12\uff0895%CI  0.89-1.40)\u3067\u3001\u975e\u52a3\u6027\u306f\u8a3c\u660e\u3055\u308c\u306a\u304b\u3063\u305f\u3002<br \/>\n&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;-<\/p>\n<p>[comments]<br \/>\n\u3053\u3053\u307e\u3067\u306f\u3001\u306a\u3093\u3089\u554f\u984c\u306a\u3044\u767a\u8868\u3068\u601d\u3044\u307e\u3059\u304c\u3001\u6b21\u304c\u5206\u304b\u308a\u307e\u305b\u3093\u3002<\/p>\n<p><\/p>\n<p><b>\u201d\u526f\u6b21\u7684\u8a55\u4fa1\u9805\u76ee\u306b\u3064\u3044\u3066\u691c\u8a0e\u3057\u305f\u3068\u3053\u308d\u3001\u5751\u816b\u760d\u52b9\u679c\u306e\u4e2d\u3067\uff08\u4e3b\u6cbb\u533b\u5224\u5b9a\uff09\u3001\u594f\u52b9\u7387\u306f\u30a4\u30ec\u30c3\u30b5\u7fa422.5%\u3001\u30c9\u30bb\u30bf\u30ad\u30bb\u30eb\u7fa412.8%\u3068\u30a4\u30ec\u30c3\u30b5\u7fa4\u3067\u6709\u610f\u306b\u9ad8\u304f\uff08p=0.009)\u3001QOL\u304a\u3088\u3073\u968f\u4f34\u75c7\u72b6\u6539\u5584\u7387\u306b\u3064\u3044\u3066\u306f\u3001FACT-L\u30b9\u30b3\u30a2(p=0.023), TOI\u30b9\u30b3\u30a2(p=0.002)\u3067\u3001\u30a4\u30ec\u30c3\u30b5\u7fa4\u3067\u6709\u610f\u306b\u826f\u597d\u3067\u3042\u3063\u305f\u3002\u201d<\/b><\/p>\n<p><\/p>\n<p>\u3053\u306e\u4e00\u9023\u306e\u30b5\u30d6\u89e3\u6790\u3067\u3001\u6bd4\u8f03\u691c\u8a0e\u9805\u76ee\u3092\u307f\u308b\u3068\u3001\u306a\u3093\u3068\u3001\uff19\u7a2e\u985e\u7a0b\u5ea6\u3067\u3059\u3002<br \/>\n\u591a\u91cd\u691c\u5b9a\u306e\u8a18\u8f09\u306f\u306a\u304f\u3001\u3053\u308c\u307b\u3069\u306e\u6570\u3092\u6bd4\u8f03\u3059\u308b\u3068\u3001\u30b3\u30a4\u30f3\u30c8\u30b9\u3042\u308b\u3044\u306f\u30b5\u30a4\u30b3\u30ed\u3067\u6614\u304b\u3089\u3088\u304f\u6559\u79d1\u66f8\u306b\u8a18\u8f09\u3055\u308c\u3066\u3044\u308b\u3088\u3046\u306b\u3001\u306a\u3093\u3089\u304b\u306e\u5dee\u304c\u3067\u308b\u78ba\u7387\u306f\u3001\u7d0440%\u3067\u3059([1-0.05]^9=0.63)\u3002\u3053\u308c\u304c14\u7a2e\u985e\u3068\u306a\u308b\u3068\u3001\u3082\u306f\u308450%\u4ee5\u4e0a\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n<p><\/p>\n<p>\u8907\u6570\u306e\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u3092\u8a2d\u5b9a\u3059\u308b\u3053\u3068\u306e\u5371\u967a\u6027\u3001\u3042\u308b\u3044\u306f<a href=\"http:\/\/www.grade-jpn.com\/grade\/guideline\/subgroup_analysis.html\" target=\"_blank\"><b>\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u89e3\u6790\u3092\u89e3\u91c8\u3059\u308b\u305f\u3081\u306e7\u3064\u306e\u57fa\u6e96<\/b><\/a>\u3092\u3001GRADE\u30b0\u30eb\u30fc\u30d7\u306f\u4ee5\u524d\u304b\u3089\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><\/p>\n<p>\u540c\u69d8\u306b\u3001Altman DG\uff08\u533b\u5b66\u7814\u7a76\u306e\u7d71\u8a08\u5b66\uff09\u306f\u3001\u533b\u5b66\u8ad6\u6587\u306e\u7d71\u8a08\u7684\u65b9\u6cd5\u306e\u8aa4\u308a\u306e\u3072\u3068\u3064\u3068\u3057\u3066\u3001<b>11\u5909\u6570\u4ee5\u4e0a\u30925%\u6c34\u6e96\u30672\u7fa4\u6bd4\u8f03<\/b>\u3068\u3044\u3046\u3053\u3068\u3092\u6307\u6458\u3057\u3066\u304a\u308a\u3001Guyatt\u3089\u3082\u3001<b>\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u89e3\u6790\u306b\u306f\u6c17\u3092\u3064\u3051\u308d\u308b\u3079\u304d<\/b>\u3068\u8aac\u660e\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><\/p>\n<p>\u672c\u8a66\u9a13\u306b\u3064\u3044\u3066GRADE\u8a55\u4fa1\u3059\u308b\u3068\uff08\u305f\u3060\u3057\u3001GRADE\u3067\u306f\u8907\u6570\u7814\u7a76\u3067\u306e\u8a55\u4fa1\u304c\u539f\u5247\u3067\u3059\u304c\uff09\u3001\u4e3b\u6cbb\u533b\u5224\u5b9a\u3068\u3044\u3046<b>limitations<\/b>\u304c\u3042\u308a\u3001\u3055\u3089\u306b\u3001\u4ee3\u7406\u30a2\u30a6\u30c8\u30ab\u30e0\u3001\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u89e3\u6790\u3067\u306ep\u5024=0.05\u3078\u306e\u3053\u3060\u308f\u308a\u306b\u3088\u308b<b>inconsistency<\/b>\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p><\/p>\n<p><a href=\"http:\/\/homepage3.nifty.com\/aihara\/grade\/guideline\/limitations.html\"><b>GRADE limitations<\/b><\/a>\u306a\u3069\u3001\u6765\u6708\u304b\u3089<b>GRADE\u30b7\u30b9\u30c6\u30e0\u306e\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3<\/b>\u306b\u3064\u3044\u3066\u7d39\u4ecb\u3057\u305f\u3044\u3002<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u6b21\u3005\u3068\u767b\u5834\u3059\u308b\u5927\u898f\u6a21\u8a66\u9a13\u3001\u591a\u65bd\u8a2d\u6bd4\u8f03\u8a66\u9a13\u306a\u3069\u306e\u591a\u7a2e\u985e\u306e\u89e3\u6790\u767a\u8868\u3092\u6211\u3005\u306f\u3069\u306e\u3088\u3046\u306b\u8a8d\u8b58\u3059\u3079\u304d\u306a\u306e\u3060\u308d\u3046\u304b\u3002 \u305d\u306e\u4e00\u4f8b\u3068\u3057\u3066\u3001\u6700\u8fd1\u306e\u56fd\u5185\u306e\u80ba\u764c\u6cbb\u7642\u306e\u7121\u4f5c\u70ba\u5316\u6bd4\u8f03\u8a66\u9a13\u7b2cIII\u76f8\u8a66\u9a13\u306b\u3064\u3044\u3066\u8003\u3048\u3066\u3001GRADE\u30b7\u30b9\u30c6\u30e0\u3067\u306f\u3069\u306e\u3088\u3046 [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[13],"tags":[104,103],"_links":{"self":[{"href":"https:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/posts\/80"}],"collection":[{"href":"https:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/aihara.la.coocan.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=80"}],"version-history":[{"count":1,"href":"https:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/posts\/80\/revisions"}],"predecessor-version":[{"id":602,"href":"https:\/\/aihara.la.coocan.jp\/index.php?rest_route=\/wp\/v2\/posts\/80\/revisions\/602"}],"wp:attachment":[{"href":"https:\/\/aihara.la.coocan.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=80"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/aihara.la.coocan.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=80"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/aihara.la.coocan.jp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=80"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}