2020年8月28日 Posted by aihara

正味の効果推定値の精確さに関する確実性(GRADE)・・・

Defining certainty of net benefit: a GRADE concept paper
https://bmjopen.bmj.com/content/9/6/e027445.long

診療ガイドライン作成における「判断の閾値・範囲」のGRADE概念の必要性が理解されない。。。。(Classification of precision of net effect estimate)

 

 
各パターンの意味が以下です。

●Classification of precision of net effect estimate

Pattern of net effect estimate Classification Precision of net effect estimate is
consistent with …
Entire CI is beneficial Net benefit High certainty of net benefit
Point estimate is beneficial, lower bound of CI is harmful and point estimate has larger absolute value than lower bound of CI Likely net benefit Moderate certainty of net benefit
Point estimate is beneficial, lower bound of CI is harmful and point estimate has smaller absolute value than lower bound of CI Possible net benefit Low certainty of net benefit
Point estimate is close to zero, wide CI* Possibly no net benefit or harm Very low certainty of net benefit or harm
Point estimate is close to zero, narrow CI* Net benefit or harm likely near zero Moderate certainty of little net benefit or harm
Point estimate is harmful, upper bound of CI is beneficial and point estimate has smaller absolute value than upper bound of CI Possible net harm Low certainty of net harm
Point estimate is harmful, upper bound of CI is beneficial and point estimate has larger absolute value than upper bound of CI Likely net harm Moderate certainty of net harm
Entire CI is harmful Net harm High certainty of net harm

*Differentiation of wide versus narrow CIs could be based on a threshold of minimally important differences.   

 

About aihara

Gordon GuyattやHolger Schunemann、Yngve Falck-YtterらとともにGRADE working groupメンバーとして、GRADEシステムの適切な普及につとめています。

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